Browsing Psychiatry by Title
Now showing items 408-427 of 437
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Synergistic Effect between Maternal Infection and Adolescent Cannabinoid Exposure on Serotonin 5HT1A Receptor Binding in the Hippocampus: Testing the "Two Hit" Hypothesis for the Development of Schizophrenia,
(2012)Infections during pregnancy and adolescent cannabis use have both been identified as environmental risk factors for schizophrenia. We combined these factors in an animal model and looked at their effects, alone and in ... -
Tailoring Cognitive Behavioral Therapy to Subtypes of Voice-Hearing.
(2015)Cognitive behavioral therapy (CBT) for voice-hearing (i.e., auditory verbal hallucinations; AVH) has, at best, small to moderate effects. One possible reason for this limited efficacy is that current CBT approaches tend ... -
Targeted Sequencing of 10,198 Samples Confirms Abnormalities in Neuronal Activity and Implicates Voltage-Gated Sodium Channels in Schizophrenia Pathogenesis
(2019)Background Sequencing studies have pointed to the involvement in schizophrenia of rare coding variants in neuronally expressed genes, including activity-regulated cytoskeleton-associated protein (ARC) and N-methyl-D-aspartate ... -
The aging brain : an investigation into cognitive training and resting state networks in healthy older adults
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2013)Investigating the complexities surrounding the aging brain is of vital importance if we are to fully understand the mechanisms of aging. A greater understanding of aging may perhaps pave the way for new ideas and innovations ... -
The contributions of knowledge and contact to the stigma of mental illness
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2008)Study One is a single face-to-face questionnaire study of 243 patients with psoriasis and/or arthritis. Because leprosy is an infectious condition, psoriasis is a better model of a stigmatising skin disorder likely to cause ... -
The effect of catecholaminergic genes on executive functions : a behavioural and fMRI study
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2009)This thesis describes a study in two parts aimed at elucidating genetic links to executive functions and their neurological correlates. The catecholamines (in particular dopamine and noradrenaline) are known to be heavily ... -
The effects of depression and electroconvulsive therapy on retrospective memory and general cognition : a longitudinal study
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2012)The objectives of this work were to investigate the effects of depression on retrospective memory, in addition to attention, psychomotor and executive function, in depressed patients receiving pharmacotherapy treatment ... -
The impact of schizophrenia genome wide association study genes on functional connectivity : a functional magnetic resonance imaging study
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2014)Genome-wide association studies (GWAS) have identified several genetic variants associated with increased schizophrenia risk. However, the specific mechanisms by which these variants increase risk are not fully understood. ... -
The impact of schizophrenia genome-wide association study genes on neurocognition and social cognition : a behavioural study
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2013)Genome wide association studies (GWAS) have established numerous previously unidentified variants associated with increased risk for schizophrenia (SZ). Exactly how most of these variants exert their influence remains ... -
The influence of Alzheimer's dementia on time spent caregiving for persons with Down Syndrome
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2003)Background: Persons with Down syndrome (DS) are at increased risk of Alzheimer’s type dementia (AD) when compared to the general population, yet little attention has been paid to the impact of the illness on such persons ... -
The neural basis of reward processing in Autism Spectrum Disorder : brain function, structure and connectivity
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2013)Autism spectrum disorder (ASD) is a pervasive developmental disorder defined by impairments in reciprocal social interaction and communication, as well as stereotyped behaviour and repetitive interests (Lord et al., 2011). ... -
Total and phosphorylated Tau protein as biological markers of Alzheimer's disease
(Elsevier, 2009)Advances in our understanding of tau-mediated neurodegeneration in Alzheimer?s disease (AD) are moving this disease pathway to center stage for the development of biomarkers and disease modifying drug discovery efforts. ... -
Transcriptome level analysis in Rett syndrome using human samples from different tissues
(BMC, 2018)The mechanisms of neuro-genetic disorders have been mostly investigated in the brain, however, for some pathologies, transcriptomic analysis in multiple tissues represent an opportunity and a challenge to understand the ... -
Transcriptomic analysis of Mecp2 mutant mice reveals differentially expressed genes and altered mechanisms in both blood and brain
(2019)Rett syndrome is a rare neuropsychiatric disorder with a wide symptomatology including impaired communication and movement, cardio-respiratory abnormalities, and seizures. The clinical presentation is typically associated ... -
Two patients walk into a clinic...a genomics perspective on the future of schizophrenia.
(BioMed Central, 2011)Progress is being made in schizophrenia genomics, suggesting that this complex brain disorder involves rare, moderate to high-risk mutations and the cumulative impact of small genetic effects, coupled with environmental ... -
Unlocking the treasure trove: From genes to schizophrenia biology
(2014)Significant progress is being made in defining the genetic etiology of schizophrenia. As the list of implicated genes grows, parallel developments in gene editing technology provide new methods to investigate gene function ... -
Use of codeine-containing medicines by Irish psychiatric in-patients before and after regulatory limitations on their supply.
(2013)Background. In recent years, concerns have been highlighted in several jurisdictions, including Ireland, regarding abuse of over-the-counter codeine-containing medicines. On the 1st of August 2010, national regulatory ... -
Using genome-wide complex trait analysis to quantify 'missing heritability' in Parkinson's disease.
(2012)Genome-wide association studies (GWASs) have been successful at identifying single-nucleotide polymorphisms (SNPs) highly associated with common traits; however, a great deal of the heritable variation associated with ...
