Browsing Psychiatry by Title
Now showing items 388-407 of 437
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Schizophrenia at a genetics crossroads: Where to now?
(2013)These are interesting times for schizophrenia genetics. The last 5 years has seen unprecedented progress, moving us from debate about putative genetic models to an understanding that susceptibility involves a complex ... -
Screening for autistic spectrum disorder at the 18-month developmental assessment: a population-based study
(2007)The objectives of this study were to assess the feasibility of administering the CHecklist for Autism in Toddlers (CHAT) at the 18-month developmental check, estimate the prevalence of screening positive for autism at the ... -
Semi-structured Interview of Moral cognitionS (SIMS)
(Trinity College Dublin, School of Medicine, Department of Psychiatry, 2018)This ‘Semi-structured Interview of Moral cognitionS’ (SIMS) is a synthesis of our experience and research in the fields of clinical/forensic psychology and forensic psychiatry. As an interview the SIMS aims to make ... -
Serotonergic System and Attention Deficit Hyperactivity Disorder (ADHD): a potential susceptibility locus at the 5-HT1B receptor gene in 270 Trios from a multi-center sample
(2002)Attention deficit hyperactivity disorder (ADHD) is a highly heritable and heterogeneous disorder, which usually becomes apparent during the first few years of childhood. Imbalance in dopamine neurotransmission has been ... -
Sex representation in neurodegenerative and psychiatric disorders' preclinical and clinical studies
(2023)Many studies show the importance of biological sex for the onset, progression, and response to treatment in brain disorders. In line with these reports, health agencies have requested that all trials, both at the clinical ... -
The SNP ratio test: pathway analysis of genome-wide association datasets
(2009)Summary: We present a tool that assesses the enrichment of significant associations from genome-wide association studies (GWAS) in a pathway context. The SNP ratio test (SRT) compares the proportion of significant to ... -
Social cognition in borderline personality disorder : an MRI investigation
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2013)There is increasing evidence for subtle changes in brain morphology and function in patients with borderline personality disorder (BPD). The four study arms in this thesis seek to investigate the differences in personality, ... -
Social dysfunction in schizophrenia: An investigation of the GAF scale's sensitivity to deficits in social cognition.
(2013)BACKGROUND: Schizophrenia is accompanied by significant impairment in psychosocial functioning, which is only partially explained by clinical symptom severity. Recently, these impairments have been strongly associated ... -
Sodium-23 Magnetic Resonance Imaging has potential for improving penumbra detection but not for estimating stroke onset time
(2014)Tissue sodium concentration increases in irreversibly damaged (core) tissue following ischemic stroke and can potentially help to differentiate the core from the adjacent hypoperfused but viable penumbra. To test this, ... -
Spatial attentional bias as a marker of genetic risk, symptom severity and stimulant response in ADHD.
(2007)Attention-deficit hyperactivity disorder (ADHD) is a heritable childhood onset disorder that is marked by variability at multiple levels including clinical presentation, cognitive profile, and response to stimulant ... -
Structural Changes of Brain Areas Involved in Emotion and Memory Processing across Lifespan
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2020)People are defined by their genes, familiar background and personal experiences, that can have either a negative or positive impact. Altogether, this represents and shapes their decisions, behaviours and relationships with ... -
Subcortical brain volume abnormalities in 2028 individuals with schizophrenia and 2540 healthy controls via the ENIGMA consortium
(2016)The profile of brain structural abnormalities in schizophrenia is still not fully understood, despite decades of research using brain scans. To validate a prospective meta-analysis approach to analyzing multicenter ... -
Subsyndromal depression and anxiety predictors, consequences and two year outcome in the Irish elderly
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2008)Depression is the commonest mental illness in late life and frequently occurs co- morbidly with anxiety. While all levels of illness severity have been reported a significant proportion of older adults suffer with clinically ... -
Susceptibility (risk and protective) factors for in-patient violence and self-harm: Prospective study of structured professional judgement instruments START and SAPROF, DUNDRUM-3 and DUNDRUM-4 in forensic mental health services
(2013)Background The START and SAPROF are newly developed fourth generation structured professional judgement instruments assessing strengths and protective factors. The DUNDRUM-3 and DUNDRUM-4 also measure positive factors, ... -
Symptoms of autism in ADHD : a familial trait in a subset of children with ADHD which correlates with comorbid oppositional defiant disorder, conduct disorder and motor disorder
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2009)Introduction; This study examines autism symptoms in a sample of children with ADHD, in their siblings, and in a control sample. Study sample: 821 children with ADHD, combined type who were participating in the International ... -
Synaptosomal-Associated Protein 25 (SNAP-25) and Attention Deficit Hyperactivity Disorder (ADHD): Evidence of linkage and Association in the Irish Population.
(2002)Several lines of evidence have suggested that ADHD is a polygenic disorder produced by the interaction of several genes each of a minor effect. Synaptosomal-associated protein 25 (SNAP-25) is a presynaptic plasma membrane ...
