Browsing Psychiatry by Title
Now showing items 256-275 of 437
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Interferon-alpha-induced cognitive and affective impairments : contributions of prefrontal cortex and hippocampal formation
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2009)Interferon-alpha (IFN-a) is a potent antiviral agent useful in the treatment of many malignancies, but most widely used in the treatment of Hepatitis C. However, sinister adverse events appear as a consequence of ... -
Interplay Between Childhood Physical Abuse and Familial Risk in the Onset of Psychotic Disorders.
(2014)Background : Childhood abuse is considered one of the main environmental risk factors for the development of psychotic symptoms and disorders. However, this association could be due to genetic factors influencing ... -
Inversion effects in the perception of the moving human form - A comparison of adolescents with autism spectrum disorder and typically developing adolescents
(2013)The “body inversion effect” refers to superior recognition of upright than inverted images of the human body and indicates typical configural processing. Previous research by Reed et al. using static images of the human ... -
Investigating clinically relevant phenotypes of neurodevelopmental copy number variants in Children and Adults
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2021)Background: Neurodevelopmental copy number variants (ND CNVs) present with clinically pleiotropic effects, transcending psychiatric diagnostic borders. Gaining clarity on the neurodevelopmental and psychiatric phenotypic ... -
Investigating risk factors and clinical correlates of copy number variants in Autism Spectrum Disorders and schizophrenia
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2013)Autism Spectrum Disorders (ASD) (OMIM 209850) and schizophrenia (OMIM 181510) are both complex neurodevelopmental disorders with extensive emotional and physical costs. Although there has been some progress in understanding ... -
Investigating the effects of schizophrenia genome-wide associated variants on white matter microstructure and brain morphology using diffusion tenson imaging and quantitative MRI
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2014)This thesis describes four studies that aim to to elucidate the effects of schizophrenia genome-wide associated variants on measures of white matter microstructure, cortical thickness, surface area and subcortical volume. ... -
Investigation of glutamatergic synapse genes in schizophrenia susceptibility : from linkage to genome-wide association studies
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2011)Schizophrenia is a common and severe mental illness which is highly heritable. Susceptibility to schizophrenia is likely to be caused by multiple genetic variants in combination with environmental risk factors. The ... -
Investigation of putative candidate genes involved in the pathogenesis of Schizophrenia using a large Irish case-control sample
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2008)This research thesis involved a candidate gene search for schizophrenia in the Irish population. It sought to identify candidate genes based on positional and functional information contained in previously published material. ... -
Investigation of rare sequence variants in putative susceptibility genes for schizophrenia and autism spectrum disorders
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2013)Schizophrenia (SZ) and Autism Spectrum Disorders (ASD) are complex neuropsychiatric disorders that have a very large health, societal and economic burden in Ireland. They affect approximately 1% and 0.8% of the population ... -
Investigation of S100B gene as a risk factor for biopolar disorder and schizophrenia
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2012)Calcium-binding protein S100B has been implicated in the pathology of bipolar affective disorder (BPAD) and schizophrenia (SZP). S100B protein levels are elevated in serum of patients with both disorders compared to controls. ... -
An investigation of the effect of maternal depression during pregnancy on maternal and infant hypothalamic-pituitary-adrenal axes
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2018)Background: Pregnancy is a period of increased vulnerability for developing depression. Several maternal physiological systems, including the hypothalamic-pituitary-adrenal (HPA) axis undergo changes during pregnancy. ... -
Investigation of the genetic association between quantitative measures of psychosis and schizophrenia: a polygenic risk score analysis.
(2012)The presence of subclinical levels of psychosis in the general population may imply that schizophrenia is the extreme expression of more or less continuously distributed traits in the population. In a previous study, we ... -
An investigation of the role of antenatal depression, maternal cortisol and postnatal interactive behaviour on infant neurodevelopment in the first year of life.
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2019)Abstract Aims: Major Depressive Disorder (MDD) is the most prevalent psychiatric disorder during the perinatal period and can lasting adverse effects on maternal wellbeing and infant development. This aim of this thesis ... -
Investigation of α-tubulins as translational biomarkers of major depressive disorder: indications for disease severity and treatment efficacy
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2020)Introduction: Major Depressive Disorder is a significant cause of disability worldwide. In a 2017 report, the World Health Organisation estimated that 320 million people suffered from depression globally. Although several ... -
Is "clinical" insight the same as "cognitive" insight in schizophrenia?
(2009)Poor insight is associated with impaired cognitive function in psychosis. Whether poor clinical insight overlaps with other aspects of self-awareness in schizophrenia, such as cognitive self-awareness, is unclear. We ... -
Is 'Clinical' insight the same as 'Cognitive' insight in schizophrenia?
(Cambridge University Press, 2009)Poor insight is associated with impaired cognitive function in psychosis. Whether poor clinical insight overlaps with other aspects of self-awareness in schizophrenia, such as cognitive self-awareness, is unclear. We ... -
Joint Analysis of the DRD5 Marker Concludes Association with Attention-Deficit/Hyperactivity Disorder Confined to the Predominantly Inattentive and Combined Subtypes
(2004)Attention-deficit/hyperactivity disorder (ADHD) is a highly heritable, heterogeneous disorder of early onset, consisting of a triad of symptoms: inattention, hyperactivity, and impulsivity. The disorder has a significant ...
