Browsing Psychiatry by Title
Now showing items 425-437 of 437
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Unlocking the treasure trove: From genes to schizophrenia biology
(2014)Significant progress is being made in defining the genetic etiology of schizophrenia. As the list of implicated genes grows, parallel developments in gene editing technology provide new methods to investigate gene function ... -
Use of codeine-containing medicines by Irish psychiatric in-patients before and after regulatory limitations on their supply.
(2013)Background. In recent years, concerns have been highlighted in several jurisdictions, including Ireland, regarding abuse of over-the-counter codeine-containing medicines. On the 1st of August 2010, national regulatory ... -
Using genome-wide complex trait analysis to quantify 'missing heritability' in Parkinson's disease.
(2012)Genome-wide association studies (GWASs) have been successful at identifying single-nucleotide polymorphisms (SNPs) highly associated with common traits; however, a great deal of the heritable variation associated with ... -
Variability in working memory performance explained by epistasis vs polygenic scores in the ZNF804A pathway.
(2014)IMPORTANCE We investigated the variation in neuropsychological function explained by risk alleles at the psychosis susceptibility gene ZNF804A and its interacting partners using single nucleotide polymorphisms (SNPs), ... -
The Wellcome trust UK-Irish bipolar affective disorder sibling-pair genome screen: first stage report
(Nature Publishing Group, 2002)We have completed the first stage of a two-stage genome wide screen designed to identify chromosomal regions that may harbour susceptibility genes for bipolar affective disorder. The first stage screening sample included ... -
What have the genomics ever done for the psychoses?
(2010)Background: Despite the substantial heritability of the psychoses and their genuine public health burden, the applicability of the genomic approach in psychiatry has been strongly questioned or prematurely dismissed.Method ... -
White matter microstructure underlying default mode network connectivity in the human brain
(2010)Resting state functional magnetic resonance imaging (fMRI) reveals a distinct network of correlated brain function representing a default mode state of the human brain. The underlying structural basis of this functional ... -
Whole genome linkage scan of recurrent depressive disorder from the depression network study
(Oxford University Press, 2005)Genome-wide linkage analysis was carried out in a sample of 497 sib pairs concordant for recurrent major depressive disorder (MDD). There was suggestive evidence for linkage on chromosome 1p36 where the LOD score for ... -
An X11[alpha]/FSBP complex represses transcription of the GSK3[beta] gene promoter.
(2010)X11? is a neuronal adaptor protein that interacts with the amyloid precursor protein (APP) via a centrally located phosphotyrosine binding (PTB) domain to inhibit production of A? peptide that is deposited in Alzheimer's ... -
X11beta rescues memory and long-term potentiation deficits in Alzheimer's disease APPswe Tg2576 mice.
(2009)Increased production and deposition of amyloid ?-protein (A?) are believed to be key pathogenic events in Alzheimer?s disease. As such, routes for lowering cerebral A? levels represent potential therapeutic targets for ... -
ZNF804A risk allele is associated with relatively intact gray matter volume in patients with schizophrenia
(Elsevier, 2010)ZNF804A rs1344706 is the first genetic risk variant to achieve genome wide significance for psychosis. Following earlier evidence that patients carrying the ZNF804A risk allele had relatively spared memory function compared ...
