Browsing Psychiatry by Title
Now showing items 159-178 of 437
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Factors affecting length of stay in forensic hospital setting: Need for therapeutic security and course of admission
(2015)BACKGROUND: Patients admitted to a secure forensic hospital are at risk of a long hospital stay. Forensic hospital beds are a scarce and expensive resource and ability to identify the factors predicting length of stay ... -
Failure to validate association between 12p13 variants and ischaemic stroke
(2010)We performed a genome-wide association study (GWAS) in 1705 Parkinson's disease (PD) UK patients and 5175 UK controls, the largest sample size so far for a PD GWAS. Replication was attempted in an additional cohort of 1039 ... -
Familial amyotrophic lateral sclerosis-linked SOD1 mutants perturb fast axonal transport to reduce axonal mitochondria content.
(Oxford University Press, 2007)Amyotrophic lateral sclerosis (ALS) is a late-onset neurological disorder characterized by death of motoneurons. Mutations in Cu/Zn superoxide dismutase-1 (SOD1) cause familial ALS but the mechanisms whereby they induce ... -
Familiality and SNP heritability of age at onset and episodicity in major depressive disorder.
(2015)BACKGROUND: Strategies to dissect phenotypic and genetic heterogeneity of major depressive disorder (MDD) have mainly relied on subphenotypes, such as age at onset (AAO) and recurrence/episodicity. Yet, evidence on ... -
Familiality of Co-existing ADHD and Tic Disorders: Evidence from a Large Sibling Study.
(2016)Background: The association of attention-deficit/hyperactivity disorder (ADHD) and tic disorder (TD) is frequent and clinically important. Very few and inconclusive attempts have been made to clarify if and how the combination ... -
Family-based association and molecular genetic analysis of genes implicated in the aetiology of autism
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2009)Autism is an early onset neurodevelopmental disorder affecting three core areas of behaviour - communication, social behaviour and restricted/repetitive behaviour. Although family and twin studies indicate a genetic ... -
Fine mapping of ZNF804A and genomime-wide significant evidence for it's involvement in Schizophrenia and bipolar disorder.
(2011)A recent genome-wide association study (GWAS) reported evidence for association between rs1344706 within ZNF804A (encoding zinc-finger protein 804A) and schizophrenia (P=1.61 × 10(-7)), and stronger evidence when the ... -
Fom Child to Adult. A Longitudinal Study of Irish Children and their Families
(Criterion Press, 2005) -
Frailty in an older population : the impact on community-dwelling elders, dementia patients and older caregivers
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2012)Frailty represents one of the greatest gerontological challenges faced by societies in coming years. Growing numbers of older citizens leads not only to increasing numbers of healthy elders, but also frail and disabled elders. -
A frailty instrument for primary care: findings from the Survey of Health, Ageing and Retirement in Europe (SHARE).
(2010)Background: A frailty paradigm would be useful in primary care to identify older people at risk, but appropriate metrics at that level are lacking. We created and validated a simple instrument for frailty screening in ... -
A framework for an evidence-based gene list relevant to autism spectrum disorder
(2020)Autism spectrum disorder (ASD) is often grouped with other brain-related phenotypes into a broader category of neurodevelopmental disorders (NDDs). In clinical practice, providers need to decide which genes to test in ... -
Fuctional and structural brain changes in ageing related to emotional processing
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2012)Of all mental abilities emotional processing is well-preserved in healthy ageing. In spite of this, the neural substrates of emotional processing in ageing are still not fully understood. In this project several experiments ... -
Functional gene group analysis identifies synaptic gene groups as risk factor for schizophrenia.
(2012)Schizophrenia is a highly heritable disorder with a polygenic pattern of inheritance and a population prevalence of _1%. Previous studies have implicated synaptic dysfunction in schizophrenia. We tested the accumulated ... -
Functional impact of global rare copy number variation in autism spectrum disorders
(2010)The autism spectrum disorders (ASDs) are a group of conditions characterized by impairments in reciprocal social interaction and communication, and the presence of restricted and repetitive behaviours(1). Individuals with ... -
Functional investigation of neurodevelopmental effects of DISC1 and related psychosis risk genes
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2015)Schizophrenia (SCZ) is a severe neurodevelopmental disorder, which affects about 1% of the population worldwide, and whose symptoms start during early adulthood. SCZ is determined by the interaction of genetic and environmental ... -
Functional magnetic resonance imaging as a dynamic candidate biomarker for Alzheimer's disease.
(Elsevier, 2011)During the last two decades, imaging of neural activation has become an invaluable tool for assessing the functional organization of the human brain in vivo. Due to its widespread application in neuroscience, functional ... -
Functional mental capacity, treatment as usual and time: Magnitude of change in secure hospital patients with major mental illness Psychiatry
(2015)BACKGROUND: Decision making ability can change with time, depending on mental or physical health. Little is known about the factors that determine this change and the relationship of capacity to time. As a pilot for ... -
Functional network mapping reveals state-dependent response to IGF-1 treatment in Rett Syndrome
(2020)Rett Syndrome (RTT) is a neurodevelopmental disorder associated with mutations in thegeneMeCP2, which is involved in the development and function of cortical networks. The clinical presentation of RTT is generally severe ...
