Browsing Psychiatry by Title
Now showing items 121-140 of 437
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Early Visual Processing Deficits in Dysbindin-Associated Schizophrenia
(2008)Background: Variation at the dysbindin gene (DTNBP1) has been associated with increased risk for schizophrenia in numerous independent samples and recently with deficits in general and domain-specific cognitive processing. ... -
Effect of Angiotensin II and Small GTPase Ras Signaling Pathway Inhibition on Early Renal Changes in a Murine Model of Obstructive Nephropathy
(2014)Tubulointerstitial fibrosis is a major feature of chronic kidney disease. Unilateral ureteral obstruction (UUO) in rodents leads to the development of renal tubulointerstitial fibrosis consistent with histopathological ... -
Effect of childhood maltreatment on brain structure in adult patients with major depressive disorder and healthy participants.
(2014)BACKGROUND: Childhood maltreatment has been found to play a crucial role in the development of psychiatric disorders. However, whether childhood maltreatment is associated with structural brain changes described for ... -
Effects of a novel schizophrenia risk variant rs7914558 at CNNM2 on brain structure and attributional style.
(2014)BACKGROUND: A single nucleotide polymorphism (rs7914558) within the cyclin M2 (CNNM2) gene was recently identified as a common risk variant for schizophrenia. The mechanism by which CNNM2 confers risk is unknown. AIMS: To ... -
Effects of MIR137 on fronto-amygdala functional connectivity.
(2014)MIR137 is implicated in brain development and encodes a microRNA that regulates neuronal maturation and adult neurogenesis. Recently, a common genetic variant within MIR137 showed genome wide evidence of association with ... -
The effects of psychosis risk variants on brain connectivity: a review.
(2012)n light of observed changes in connectivity in schizophrenia and the highly heritable nature of the disease, neural connectivity may serve as an important intermediate phenotype for schizophrenia. However, how individual ... -
Effects of the neurogranin variant rs12807809 on thalamocortical morphology in schizophrenia.
(2013)Although the genome wide supported psychosis susceptibility neurogranin (NRGN) gene is expressed in human brains, it is unclear how it impacts brain morphology in schizophrenia. We investigated the influence of NRGN ... -
Electroconvulsive therapy - state of the art
(The Royal College of Physicians, 2003)Although electroconvulsive therapy (ECT) has been available for more than 60 years it is still the most acutely effective antidepressant treatment available (McCall, 2001). However, despite substantial advances in safety ... -
Electroconvulsive therapy for depression : optimising treatment and exploring molecular mechanisms
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2016)The objective of this project was to explore clinical and molecular aspects of electroconvulsive therapy (ECT) in the treatment of depression, with a particular focus on the role of microRNAs (small, non-coding molecules ... -
Electroconvulsive therapy for depression and ketamine for relapse prevention: factors affecting response, cognition and research participation
This thesis comprises five clinical research studies. Study 1. Pilot randomised controlled trial: Ketamine vs midazolam for depression relapse prevention following successful electroconvulsive therapy (ECT), the ... -
Electroconvulsive therapy, capacity and the law in Ireland.
(Irish Institute of Psychological Medicine, 2009)The Mental Health Act (MHA) 2001 has major implications for treating patients with electroconvulsive therapy (ECT), especially as those referred for treatment are among the most severely ill and often lose capacity. Under ... -
Electrophysiological event-related-potentials & their association with genome-wide-associated risk variants in schizophrenia
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2012)This thesis describes the use of electrophysiological event- related-potentials as a method for understanding, at the cortical level, the functional significance of putative schizophrenia susceptibility genes identified ... -
Enhancing studies of the connectome in autism using the autism brain imaging data exchange II
(2017)The second iteration of the Autism Brain Imaging Data Exchange (ABIDE II) aims to enhance the scope of brain connectomics research in Autism Spectrum Disorder (ASD). Consistent with the initial ABIDE effort (ABIDE I), that ... -
The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data.
(2014)The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Consortium is a collaborative network of researchers working together on a range of large-scale studies that integrate data from 70 institutions worldwide. ... -
Epigenetic variance in dopamine D2 receptor: a marker of IQ malleability?
(2018)Genetic and environmental factors both contribute to cognitive test performance. A substantial increase in average intelligence test results in the second half of the previous century within one generation is unlikely to ... -
Epigenetics and depression: return of the repressed
(2014)Introduction: Epigenetics has recently emerged as a potential mechanism by which adverse environmental stimuli can result in persistent changes in gene expression. Epigenetic mechanisms function alongside the DNA sequence ...
