Browsing Psychiatry by Title
Now showing items 86-105 of 437
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Decreased integrity of the fronto-temporal fibers of the left inferior occipito-frontal fasciculus associated with auditory verbal hallucinations in schizophrenia
(2016)Auditory verbal hallucinations (AVH: 'hearing voices') are found in both schizophrenia and post-traumatic stress disorder (PTSD). In this paper we first demonstrate that AVH in these two diagnoses share a qualitatively ... -
Deep Learning for Neuroimaging: Advancing Brain-Based Biomarkers of Autism Spectrum Disorder
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2023)In the last decade, deep learning (DL) has revolutionised fields like speech and vision through artificial neural networks. Can DL similarly transform biological psychiatry and neuroimaging? This thesis explores that ... -
The Depression Network (DeNT) Study: Methodology and Sociodemographic characteristics of the first 470 affected sibling pairs from a large multi-site linkage genetics study
(BMC, 2004)Background: The Depression Network Study (DeNt) is a multicentre study designed to identify genes and/or loci linked to and/or associated with susceptibility to unipolar depression in Caucasian families. This study ... -
Depth-Dependent Differences in Community Structure of the Human Colonic Microbiota in Health
(2013)Objective The aims of this study were to develop techniques for spatial microbial assessment in humans and to establish colonic luminal and mucosal spatial ecology, encompassing longitudinal and cross-sectional ... -
Derivation of four iPSC lines from a male ASD patient carrying a deletion in the middle coding region of NRXN1α gene (NUIGi039-A and NUIGi039-B) and a male sibling control (NUIGi040-A and NUIGi040-B)
(2021)NRXN1 deletions are commonly found in autism spectrum disorder (ASD) and other neurodevelopmental/neuropsychiatric disorders. Derivation of induced pluripotent stem cells (iPSCs) from different diseases involving different ... -
Derivation of iPSC lines from three young healthy donors of Caucasian origin (NUIGi035-A; NUIGi036-A; NUIGi037-A)
(2020)The induced pluripotent stem cell (iPSC) technology has offered an unprecedented opportunity for disease modelling and drug discovery. Here we used non-integrating Sendai viral method and derived iPSCs from three young ... -
Derivation of iPSC lines from two patients with autism spectrum disorder carrying NRXN1α deletion (NUIGi041-A, NUIG041-B; NUIGi045-A) and one sibling control (NUIGi042-A, NUIGi042-B)
(2021)NRXN1 encodes thousands of splicing variants categorized into long NRXN1α, short NRXN1β and extremely short NRXN1γ, which exert differential roles in neuronal excitation/inhibition. NRXN1α deletions are common in autism ... -
Derivation of two iPSC lines from a sporadic ASD patient (NUIGi033-A) and a paternal control (NUIGi034-A)
(2020)Hundreds of rare risk factors have been identified for ASD, however, the underlying causes for ~70% of sporadic cases are unknown. Sporadic ASD models are thus essential for validating phenotypic commonality and drug ... -
Developing pedigree-based strategies to analyse whole genome sequencing data for complex disorders: learning from schizophrenia
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2023)Complex genetic disorders are impacted by a range of DNA variation. Next generation sequencing (NGS) allows for the direct examination of this variation, but large sample numbers are required to identify rare variants in ... -
Development of Strategies for SNP Detection in RNA-Seq Data: Application to Lymphoblastoid Cell Lines and Evaluation Using 1000 Genomes Data.
(2013)Next-generation RNA sequencing (RNA-seq) maps and analyzes transcriptomes and generates data on sequence variation in expressed genes. There are few reported studies on analysis strategies to maximize the yield of quality ... -
Development of trofinetide for the treatment of Rett syndrome: from bench to bedside
(2024)Rett syndrome (RTT) is rare neurodevelopmental disorder caused by mutations in the MECP2 gene that encodes methyl-CpG-binding protein 2 (MeCP2), a DNA-binding protein with roles in epigenetic regulation of gene expression. ... -
Developmental comorbidity assessment in childhood ADHD
(2003)Introduction: Childhood ADHD typically presents with comorbidites. Assessment tools for developmental screening vary greatly in length and complexitity, and parental preference has an impact on the usefulness of clinical ... -
Differential default mode network trajectories in asymptomatic individuals at risk for Alzheimer's disease
(2019)Introduction: The longitudinal trajectories of functional brain dynamics and the impact of genetic risk factors in individuals at risk for Alzheimer's disease are poorly understood. Methods: In a large-scale monocentric ...
