Browsing Psychiatry by Title
Now showing items 35-54 of 437
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Basal forebrain volume, but not hippocampal volume, is a predictor of global cognitive decline in patients with alzheimer's disease treated with cholinesterase inhibitors
(2018)Background: Predicting the progression of cognitive decline in Alzheimer's disease (AD) is important for treatment selection and patient counseling. Structural MRI markers such as hippocampus or basal forebrain volumes ... -
Bereavement and people with intellectual disabilities
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2007)For most people, the loss of a loved one is a tragedy unequalled by any other. It affects every family and raises policy and logistic issues for the health and social service agencies of every community. Currently, people ... -
Bio-collections in autism research.
(2017) -
Biological overlap of attention-deficit/hyperactivity disorder and autism spectrum disorder: evidence from copy number variants.
(2014)Objective Attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) often co-occur and share genetic risks. The aim of this analysis was to determine more broadly whether ADHD and ASD share ... -
Bipolar affective puerperal psychosis- genome-wide significant evidence for linkage to chromosome 16.
(American Psychiatric Publishing, 2007)OBJECTIVE: Vulnerability to the triggering of bipolar episodes by childbirth aggregates in families and may define a genetically relevant subtype of bipolar disorder. The authors conducted a search by systematic whole ... -
Brain Aβ load association and sexual dimorphism of plasma BACE1 concentrations in cognitively normal individuals at risk for AD
(2019)Introduction: Successful development of effective β-site amyloid precursor protein cleaving enzyme 1 (BACE1)–targeted therapies for early stages of Alzheimer's disease requires biomarker-guided intervention strategies ... -
Brain structure, function and connectivity in Autism Spectrum Disorders
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2012)In this study, two neuroimaging modalities were used to investigate neural connectivity in individuals with autism spectrum disorder; functional magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI). -
Brain vs Behavior: An Effect Size Comparison of Neuroimaging and Cognitive Studies of Genetic Risk for Schizophrenia.
(2013)Genetic variants associated with increased risk for schizophrenia (SZ) are hypothesized to be more penetrant at the level of brain structure and function than at the level of behavior. However, to date the relative sensitivity ... -
BRAIN: Brain Injury in Neonates
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2022)Despite advances in neonatal care leading to a dramatic reduction in mortality rates in recent decades, there have been comparatively modest improvements in neurodevelopmental outcomes for infants born with neonatal ... -
The c-Abl tyrosine kinase phosphorylates the Fe65 adaptor protein to stimulate Fe65/amyloid precursor protein nuclear signaling.
(American Society for Biochemistry and Molecular Biology, 2004)The amyloid precursor protein (APP) is proteolytically processed to release a C-terminal domain that signals to the nucleus to regulate transcription of responsive genes. The APP C terminus binds to a number of phosphotyrosine ... -
A "Candidate-Interactome" Aggregate Analysis of Genome-Wide Association Data in Multiple Sclerosis
(2013)Though difficult, the study of gene-environment interactions in multifactorial diseases is crucial for interpreting the relevance of non-heritable factors and prevents from overlooking genetic associations with small but ... -
Caring for a child with an autistic spectrum disorder over the life span
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2003)Carers of children on the autistic spectrum have stressful lives (Randall & Parker, 1999). The aim of this study was to investigate the life of the carer, and in particular to examine how they have coped, their support ... -
Category fluency, latent semantic analysis and schizophrenia: a candidate gene approach
(2014)Background Category fluency is a widely used task that relies on multiple neurocognitive processes and is a sensitive assay of cortical dysfunction, including in schizophrenia. The test requires naming of as many words ... -
Characterisation of MACROD2, a putative autism susceptibility gene : translating Genome-Wide Analysis to causation
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2013)Genome Wide Association studies (GWAS) have been used to identify genetic markers which have strong statistical association with a disease. Establishing a functional consequence of association is required to determine a ... -
Characterising schizophrenia candidate susceptibility genes using intermediate phenotypes
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2008)This thesis describes the use of intermediate phenotypes as a method for understanding, at a behavioural level, the functional significance of candidate susceptibility genes for schizophrenia. The historical context for ... -
Cigarette smoking and psychotic symptoms in bipolar affective disorder
(The Royal College of Psychiatrists, 2001)Background An association exists between smoking and schizophrenia, independent of other factors and related to psychotic symptomatology. Aims To determine whether smoking is associated with psychosis in bipolar affective ... -
Classical Human Leukocyte Antigen Alleles and C4 Haplotypes Are Not Significantly Associated With Depression
(2020)BACKGROUND: The prevalence of depression is higher in individuals with autoimmune diseases, but the mechanisms underlying the observed comorbidities are unknown. Shared genetic etiology is a plausible explanation for ... -
Clinical and Genetic Rett Syndrome Variants are Defined by Stable Electrophysiological Profiles
(2018)Background: Rett Syndrome (RTT) is a complex neuro developmental disorder, frequently associated with epilepsy. Despite increasing recognition of the clinical heterogeneity of RTT and its variants (e.g Classical, Hanefeld ...
