Browsing Psychiatry by Title
Now showing items 1-20 of 437
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A candidate gene search for autism
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2006)This research involved a candidate gene search for autism in the Irish population. It sought to identify candidate genes based on information from linkage studies, reports of chromosomal abnormalities, animal studies and ... -
A genome-wide association study for genetic susceptibility to Mycobacterium bovis infection in dairy cattle identifies a susceptibility QTL on chromosome 23
(2016)Background: Bovine tuberculosis (bTB) infection in cattle is a significant economic concern in many countries, with annual costs to the UK and Irish governments of approximately �190 million and �63 million, respectively, ... -
A molecular genetic investigation of schizophrenia in an Irish study population
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2006)Schizophrenia (OMIM 181500) is a complex genetic disorder, which affects ~1% of the population, and typically presents in early adulthood with abnormalities of perception (psychosis), cognition, information processing and ... -
Abnormal functional connectivity during visuospatial processing is associated with disrupted organisation of white matter in autism.
(2013)Disruption of structural and functional neural connectivity has been widely reported in Autism Spectrum Disorder (ASD) but there is a striking lack of research attempting to integrate analysis of functional and structural ... -
Abnormal functional connectivity in autism spectrum disorder is associated with disrupted white matter microstructural organisation
(2013)Disruption of structural and functional neural connectivity has been widely reported in Autism Spectrum Disorder (ASD) but there is a striking lack of research attempting to integrate analysis of functional and structural ... -
Accurately assessing the risk of schizophrenia conferred by rare copy-number variation affecting genes with brain function.
(2010)Investigators have linked rare copy number variation (CNVs) to neuropsychiatric diseases, such as schizophrenia. One hypothesis is that CNV events cause disease by affecting genes with specific brain functions. Under these ... -
Age-related hearing loss and neurocognitive function: Normal and pathological processes in cognitive ageing
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2018)This thesis investigates age-related hearing loss (ARHL) as a potential biomarker and risk factor for cognitive decline and dementia. Two reviews were conducted to examine the evidence for an association in the epidemiological ... -
Age-related networks of regional covariance in MRI gray matter: Reproducible multivariate patterns in healthy aging
(Elsevier, 2009)Healthy aging is associated with brain volume reductions that involve the frontal cortex, but also affect other brain regions. We sought to identify an age-related network pattern of MRI gray matter using a multivariate ... -
Allelic differences between Europeans and Chinese for CREB1 SNPs and their implications in gene expression regulation, hippocampal structure and function, and bipolar disorder susceptibility.
(2014)Bipolar disorder (BD) is a polygenic disorder that shares substantial genetic risk factors with major depressive disorder (MDD). Genetic analyses have reported numerous BD susceptibility genes, while some variants, such ... -
ALS2/Alsin regulates Rac-PAK signaling and neurite outgrowth.
(American Society for Biochemistry and Molecular Biology, 2005)Rac and its downstream effectors p21-activated kinase (PAK) family kinases regulate actin dynamics within growth cones to control neurite outgrowth during development. The activity of Rac is stimulated by guanine ... -
Amyloid ? peptides in plasma in early diagnosis of Alzheimer's disease: A multicenter study with multiplexing
(Elsevier, 2009)We measured concentrations of A? peptides 1?42 and 1?40, and their ratio in plasma of patients carefully categorized clinically and neurochemically as having AD or other dementias with a newly commercially available ... -
Amyotrophic lateral sclerosis mutant vesicle-associated membrane protein-associated protein-B transgenic mice develop TAR-DNA-binding protein-43 pathology.
(2010)Cytoplasmic ubiquitin-positive inclusions containing TAR-DNA-binding protein-43 (TDP-43) within motor neurons are the hallmark pathology of sporadic amyotrophic lateral sclerosis (ALS). TDP-43 is a nuclear protein and the ... -
Analysis of 10 independent samples provides evidence for association between schizophrenia and a SNP flanking fibroblast growth factor receptor 2.
(2009)We and others have previously reported linkage to schizophrenia on chromosome 10q25-q26 but, to date, a susceptibility gene in the region has not been identified. We examined data from 3606 SNPs mapping to 10q25-q26 that ... -
Analysis of the hexanucleotide repeat expansion and founder haplotype at C9ORF72 in an Irish psychosis case-control sample.
(2014)The hexonucleotide repeat expansion 'GGGGCC' at the C9ORF72 gene has been strongly linked with amyotrophic lateral sclerosis and frontotemporal dementia. There is some evidence for clinical and genetic overlap between ... -
Ancestral Legacies of an Insular Archipelago: A genomic exploration of prehistoric Japan and mainland Asia
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2022)The objective of this thesis is to use ancient genomic data and a variety of bioinformatic approaches to explore human evolutionary history in the Japanese archipelago and mainland Asia. This thesis presents a dense genomic ...
