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dc.contributor.authorGILL, MICHAELen
dc.contributor.authorHAWI, ZIARIHen
dc.date.accessioned2010-01-26T12:31:51Z
dc.date.available2010-01-26T12:31:51Z
dc.date.issued2004en
dc.date.submitted2004en
dc.identifier.citationN. Lowe, A. Kirley, Z. Hawi, P. Sham, H. Wickham, C. J. Kratochvil, S. D. Smith, S. Y. Lee, F. Levy, L. Kent, F. Middle, L. A. Rohde, T. Roman, E. Tahir, Y. Yazgan, P. Asherson, J. Mill, A. Thapar, A. Payton, R. D. Todd, T. Stephens, R. P. Ebstein, I. Manor, C. L. Barr, K. G. Wigg, R. J. Sinke, J. K. Buitelaar, S. L. Smalley, S. F. Nelson, J. Biederman, S. V. Faraone and M. Gill, Joint Analysis of the DRD5 Marker Concludes Association with Attention-Deficit/Hyperactivity Disorder Confined to the Predominantly Inattentive and Combined Subtypes, American Journal of Human Genetics, 74, 2, 2004, 348-356en
dc.identifier.otherYen
dc.identifier.urihttp://hdl.handle.net/2262/36347
dc.descriptionPUBLISHEDen
dc.descriptionPMID: 14732906en
dc.description.abstractAttention-deficit/hyperactivity disorder (ADHD) is a highly heritable, heterogeneous disorder of early onset, consisting of a triad of symptoms: inattention, hyperactivity, and impulsivity. The disorder has a significant genetic component, and theories of etiology include abnormalities in the dopaminergic system, with DRD4, DAT1, SNAP25, and DRD5 being implicated as major susceptibility genes. An initial report of association between ADHD and the common 148-bp allele of a microsatellite marker located 18.5 kb from the DRD5 gene has been followed by several studies showing nonsignificant trends toward association with the same allele. To establish the postulated association of the (CA)n repeat with ADHD, we collected genotypic information from 14 independent samples of probands and their parents, analyzed them individually and, in the absence of heterogeneity, analyzed them as a joint sample. The joint analysis showed association with the DRD5 locus (P=.00005; odds ratio 1.24; 95% confidence interval 1.12?1.38). This association appears to be confined to the predominantly inattentive and combined clinical subtypes.en
dc.description.sponsorshipHealth Research Boarden
dc.format.extent348-356en
dc.format.mimetypeapplication/pdf
dc.language.isoenen
dc.relation.ispartofseriesAmerican Journal of Human Geneticsen
dc.relation.ispartofseries74en
dc.relation.ispartofseries2en
dc.rightsYen
dc.subjectPsychiatry
dc.titleJoint Analysis of the DRD5 Marker Concludes Association with Attention-Deficit/Hyperactivity Disorder Confined to the Predominantly Inattentive and Combined Subtypesen
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/mgillen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/zhhawien
dc.identifier.rssinternalid21215en
dc.identifier.doihttp://dx.doi.org/10.1086/381561en
dc.identifier.rssurihttp://dx.doi.org/10.1086/381561
dc.contributor.sponsorHealth Research Board (HRB)en


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