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dc.contributor.authorO'NEILL, LUKE ANTHONY JOHN
dc.date.accessioned2009-10-05T15:03:05Z
dc.date.available2009-10-05T15:03:05Z
dc.date.issued1995
dc.date.submitted1995en
dc.identifier.citationHassan J, O'Neill S, O'Neill LA, Pattison U, Reen DJ. `Signalling via CD28 of human naive neonatal T lymphocytes? in Clinical and Experimental Immunology, 102, (1), 1995, pp 192 - 198en
dc.identifier.otherYen
dc.identifier.otherY
dc.identifier.urihttp://hdl.handle.net/2262/33732
dc.descriptionPUBLISHEDen
dc.description.abstractAccessory molecules play a crucial role in the development of the T cell response to antigenic challenge. We have examined the role of CD28 in modulating the 'naive' neonatal T cell response to anti-CD2-mediated activation. To compare the role of CD28, neonatal and adult T cells were stimulated with a pair of mitogenic anti-CD2 antibodies in the presence or absence of anti-CD28 MoAb. With anti-CD2 alone, neonatal T cells proliferated slightly but produced no detectable IL-2, whereas adult T cells proliferated vigorously, with significant IL-2 production. Costimulation with anti-CD28 MoAb greatly enhanced the proliferative response of neonatal T cells to levels equivalent to those of adult T cells, whereas adult T cells showed only slight increases. Although IL-2 secretion was increased in the presence of anti-CD28 MoAb, neonatal T cell IL-2 production remained lower than in adults. In contrast, enhancement of IL-2 mRNA expression in neonates was similar to adult levels. Anti-CD28 MoAb costimulation increased NF kappa B levels in neonates, albeit to levels lower than that of adults. The cellular mechanism governing the diminished proliferative response of neonatal T lymphocytes to anti-CD2 may therefore be due to decreased NF kappa B induction, reduced IL-2 mRNA expression and deficient IL-2 production. Although anti-CD28 MoAb costimulation enhances all of the above signals, NF kappa B and IL-2 levels remain lower than in adults, suggesting the need for further activation requirements in the neonate.en
dc.format.extent997659 bytes
dc.format.extent192en
dc.format.extent198en
dc.format.mimetypeapplication/pdf
dc.language.isoenen
dc.publisherBritish Society for Immunologyen
dc.relation.ispartofseriesClinical and Experimental Immunologyen
dc.relation.ispartofseries102en
dc.relation.ispartofseries1en
dc.rightsYen
dc.subjectneonatal T cells CD28 IL-2 mRNA NFKBen
dc.titleSignalling via CD28 of human naive neonatal T lymphocytes.en
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/laoneill
dc.identifier.rssinternalid5038
dc.contributor.sponsorScience Foundation Ireland


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