RSS 1.0School of Genetics & Microbiology
Academic/Research Units within this Academic/Research Unit
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Biology Teaching Centre
Biology Teaching Centre -
Genetics
Genetics -
Microbiology
Microbiology
Recent Submissions
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Stories spun in DNA: Unravelling the fine-scale genomics of ancient Scotland
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, School of Genetics and Microbiology, 2025)The growing field of ancient genomics has revealed the broad genomic changes associated with major archaeological horizons in past Britain and Ireland. It has been established that genomic continuity exists between the ... -
Inner Blood Retinal Barrier integrity in the pathogenesis of Retinitis Pigmentosa
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2025)Retinitis Pigmentosa (RP) is the most prevalent form of Inherited Retinal Degeneration, estimated to impact 1 in 4000 people across Ireland. The disease is characterized by enhanced genetic complexity which restricts the ... -
The inner Blood-Retina Barrier in Age-related Macular Degeneration
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2025)Age-related macular degeneration (AMD) is the leading cause of blindness in aged populations worldwide. AMD involves the gradual deterioration of central retinal vision overtime but the exact pathobiological mechanisms are ... -
An Investigation of Regulatory and Chromatin Drivers of Cancer
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2025)Chromatin and its regulatory elements are crucial for controlling gene expression and maintaining cellular identity. Chromatin, a dynamic structure made of DNA and histone proteins, is organized into nucleosomes. Modifications ... -
Ancient genomics and the origin, dispersal, and development of domestic sheep
(2025)The origins and prehistory of domestic sheep (Ovis aries) are incompletely understood; to address this we generated data from 118 ancient genomes spanning 12,000 years sampled from across Eurasia. Genomes from Central ... -
Characterising the small RNA-regulatory architecture of Acinetobacter baumannii
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Microbiology, 2025)The Gram-negative bacterium Acinetobacter baumannii is a significant opportunistic pathogen in critically ill and hospitalised patients. It exhibits a remarkable ability to survive under harsh environmental conditions, ... -
Characterisation of the alternative sigma factor SigAB in Acinetobacter baumannii
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Microbiology, 2024)Acinetobacter baumannii is a priority pathogen and is known to be a leading cause of nosocomial infections worldwide. It is associated with a variety of illnesses including septicaemia, pneumonia, and urinary tract ... -
Molecular Control of Cell Stress-initiated Inflammation
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2025)Inflammation is the cornerstone of homeostasis. At one end of the spectrum, inflammation is activated by severe disturbances to homeostasis, typically as a result of infection or injury. Inflammation in this context is ... -
Molecular characterisation of tagO-deficient mutants of Staphylococcus aureus
(Trinity College (Dublin, Ireland). Department of Microbiology, 2017)Wall teichoic acid (W TA) is a major component of the Gram -positive bacterial cell wall. Despite not being essential, it plays important roles in cell growth, division, morphology and virulence. The enzyme TagO initiates ... -
An investigation of LytE in fulfilling the D,L-endopeptidase requirement for viability of Bacillus subtilis
(Trinity College (Dublin, Ireland). Department of Genetics, 2016)The bacterial cell wall determines cell shape, resists turgor pressure, provides a microclimate between the cell and the external milieu and acts as a platform for the exposure of cellular proteins. The cell wall is a ... -
Neurophysiological changes associated with olfactory short-term habituation in Drosophilia melanogaster
(Trinity College (Dublin, Ireland). Department of Genetics, 2016)The term habituation describes a simple form of learning that is characterized by a behavioural response decrement following repeated or prolonged sensory stimulation (Christoffersen, 1997; Rankin et al, 2009; Thompson and ... -
Exploring the function of SUPERMAN, and the repression of the trichome initiation pathway, during Arabidopsis flower development
(Trinity College (Dublin, Ireland). Department of Genetics, 2017)The notion that flowers are in essence modified leaves was hypothesized as far back as 1790. Supporting this early hypothesis, genetic analyses of floral organ identity genes in the model plant Arahidopsis thaliana showed ... -
Investigation of the PhoPR two-component signal transduction system in Bacillus subtilis, Staphylococcus aureus and Staphylococcus epidermidis
(Trinity College (Dublin, Ireland). Department of Genetics, 2017)The objectives of this study were (i) to establish the mechanism by which the PhoPR TCS is activated and deactivated in Bacillus subtilis subsp subtilis (strain 168) and subsp spizizenii (strain W23) and (ii) to determine ... -
Analysis of the mechanism of protein A release and its contribution to immune evasion by Staphylococcus aureus
(Trinity College (Dublin, Ireland). Department of Microbiology, 2016)The immunoglobulin binding protein A (SpA) of Staphylococcus aureus was one of the first cell wall-associated proteins of Gram-positive bacteria to be identified and characterised. It is synthesized as a precursor with a ... -
A history of multiple Denisovan introgression events in modern humans
(2024)The identification of a new hominin group in the Altai mountains called Denisovans was one of the most exciting discoveries in human evolution in the last decade. Unlike Neanderthal remains, the Denisovan fossil record ... -
Population genetics of Ancient Western Europe
(Trinity College (Dublin, Ireland). Department of Genetics, 2017)The field of Ancient DNA has been the subject of significant progress during the last decade, shifting from the analysis of a few hundred basepairs to whole-genome data. The main advantage of ancient DNA is the direct ... -
Control of floral meristem activity in the model plant Arabidopsis thaliana
(Trinity College (Dublin, Ireland). Department of Genetics, 2017)Over the past 30 years, the flower development has been one of the main model to study the genetic control of organogenesis in higher plants. The work on Arahidopsis thaliana has led to the proposal of the ABC model of ... -
Genomic and transcriptomic profiling of Coeliac Disease
(Trinity College (Dublin, Ireland). Department of Genetics, 2016)Coeliac Disease (CD) is a chronic immune mediated disease triggered by the ingestion of gluten. It has an estimated prevalence of approximately 1% in European populations. Genome-wide association studies (GWAS) have ... -
Neutrophil-derived proteases act as global regulators of IL-1 family cytokine activation states
(Trinity College (Dublin, Ireland). Department of Genetics, 2016)IL-1 family cytokines are pleiotropic cytokines capable of eliciting robust proinflammatory cytokine and chemokine secretion from a broad variety of cell types and tissues. Recent evidence has strongly implicated IL-36 ... -
Investigating the contributions to cell function of the different Swi-Snf complex subunits in Saccharomyces cerevisiae
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Microbiology, 2024)The eukaryotic genome is packaged as a DNA-protein structure known as chromatin. The basic subunit of chromatin is the nucleosome, which contains two copies of each of the core histone proteins H2A, H2B, H3, and H4, around ...
