Browsing Administrative Staff Authors (Scholarly Publications) by Sponsor "Wellcome Trust"
Now showing items 1-7 of 7
-
Evolution of the Cerebellar Cortex: Selective expansion of prefrontal-projecting lobules
(2009)It has been suggested that interconnected brain areas evolve in tandem because evolutionary pressures act on complete functional systems rather than individual brain areas. The cerebellar cortex has reciprocal connections ... -
The Gene Regulatory Cascade Linking Proneural Specification with Differentiation in Drosophila Sensory Neurons
(2010)In neurogenesis, neural cell fate specification is generally triggered by proneural transcription factors. Whilst the role of proneural factors in fate specification is well studied, the link between neural specification ... -
Intragenic Copy Number Variation within Filaggrin Contributes to the Risk of Atopic Dermatitis with a Dose-Dependent Effect
(2012)Loss-of-function variants within the filaggrin gene (FLG) increase the risk of atopic dermatitis. FLG also demonstrates intragenic copy number variation (CNV), with alleles encoding 10, 11, or 12 filaggrin monomers; hence, ... -
Loss of viral fitness and cross-recognition by CD8+ T cells limit HCV escape from a protective HLA-B27-restricted human immune response
(American Society for Clinical Investigation, 2009)There is an association between expression of the MHC class I molecule HLA-B27 and protection following human infection with either HIV or HCV. In both cases, protection has been linked to HLA-B27 presentation of a single ... -
Molecular footprints reveal the impact of the protective HLA-A*03 allele in hepatitis C virus infection.
(2011)Background and aims: CD8 T cells are central to the control of hepatitis C virus (HCV) although the key features of a successful CD8 T cell response remain to be defined. In a cohort of Irish women infected by a single ... -
Protein kinase C isotypes theta, delta and eta in human lymphocytes: differential responses to signalling through the T-cell receptor and phorbol esters
(1997)The repertoire of novel and atypical protein kinase C (PKC) isotypes present in human T cells and their subcellular localization have not been fully characterized. We detected calcium-independent PKC activity in whole cell ...
