Browsing Pharmacy and Pharmaceutical Sciences (Theses and Dissertations) by Subject "ibuprofen"
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Factors affecting the stability and performance of amorphous solid dispersions of poorly soluble active pharmaceutical ingredients
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2020)This thesis focuses on factors affecting the stability and performance of amorphous solid dispersions (ASDs) of poorly soluble active pharmaceutical ingredients (APIs). The poor aqueous solubility of pipeline drugs has ... -
Using in vitro and in silico approaches to investigate ibuprofen particulate and formulation dissolution behaviour under different hydrodynamic conditions.
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2024)This work investigated the effect of fluid velocity and medium viscosity on the dissolution of ibuprofen powder and ibuprofen immediate release tablets in vitro, in the paddle apparatus and the flow-through apparatus, and ...
