Browsing Pharmacy and Pharmaceutical Sciences (Theses and Dissertations) by Title
Now showing items 82-101 of 156
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Investigatons of the potential of crystalline excipients to prevent the process-induced amorphisation of active pharmaceutical ingredients
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2014)The focus of this thesis was to evaluate the impact of mechanical activation (milling and dry mixing) and spray drying on the crystallinity of selected active pharmaceutical ingredients (APIs) and to explore the feasibility ... -
A journey from ethnomedicine in rural Kenya to network pharmacology using a critical research approach
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2023)Background: Traditional medicine (TM) is widely practiced globally, with inter-country figures on usage ranging from 30 to 90%. Research on TM is conducted for a multiplicity of reasons, among them health care and ... -
Kinetic and structural studies of novel isosorbide-based ligand binding to esterase enzymes
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2009)The main goal of the project described herein was to examine and rationalise the binding of a novel class of compound based on isosorbide to cholinesterase enzymes. The compounds of interest had been prepared within the ... -
Liposomes as carriers for systemic delivery of salmon calcitonin by inhalation
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2011)The concept of delivering proteins and peptides to the systemic circulation via the lungs has been extensively investigated over the last 20 years. Main drivers for the approach are the lungs’ high surface area, presumed ... -
The manufacture of fixed dose combination products using advanced pharmaceutical techniques for the treatment of cardiovascular disease and type II diabetes
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2020)The thesis has focused on the use of continuous manufacturing techniques to produce fixed dose combination (FDC) products for the treatment of type II diabetes mellitus and cardiovascular diseases (CVDs). FDC products with ... -
Mechanistic aspects of the degradation and drug release properties of poly-alpha-hydroxyl aliphatic ester nano- and microparticle
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2000)Particulate systems based on the polymers of lactic and glycolic acids have been extensively investigated as drug delivery technologies, particularly as vehicles to achieve controlled release. The release kinetics from ... -
Mechanistic studies into the effect of deoxycholic acid on oesophageal cancer initiation and progression
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2015)Oesophageal cancer is the ranked as the fifth highest cancer in terms of cancer-related deaths worldwide and has an incidence rate that is increasing by 5% annually. Survival rates for oesophageal cancer are approximately ... -
Mechanistics aspects of the release of drugs from hydrophilic polymer matrices
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2001)Hydrophilic polymers, which both swell and erode, are widely used to produce sustained release of drugs from monolithic matrices, and have been extensively reviewed in the literature (Alderman 1984), (Peppas and Korsmeyer ... -
Mechanochemical Synthesis and Physicochemical Characterisation of Multicomponent Phases Comprising Lidocaine and Dicarboxylic Acids
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2023)Tuning of physicochemical properties of multicomponent phases incorporating active pharmaceutical ingredients (APIs) with counterions or coformers is a challenge that opens up unlimited possibilities for expanding applications ... -
Mesoporous Silica Nanocarriers for triggered drug delivery in the treatment of cancer
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2023)Cancer is the second leading cause of death globally, accounting for 10 million deaths in 2020. Cancer chemotherapy is currently limited by a high systemic toxicity that occurs as a result of high systemic dosing and the ... -
Milking extracellular vesicles for health benefit using a multi-omics approach
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2023)Milk is remarkable source of nutrients (i.e., proteins, fat, and sugars) and extracellular vesicles (EVs). EVs are tiny vesicles release by cells into all biofluids including milk. Milk EVs have been gathered huge attention ... -
A mixed-methods approach to explore the association between age and medication -related problems among adults
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2024)General introduction Much attention was focused on the ageing phenomenon and how to improve the quality of life in older people. Medication-related problems (MRPs) can potentially lead to hospital admissions, increased ... -
Moral reasoning competencies development in community pharmacists in Ireland : a repeated measures crossover study
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2015)Research suggests that higher levels of moral reasoning competencies increase the probability that community pharmacists will make decisions in the patient's 'best interests'. Professional ethics education incorporates the ... -
Multimodal magnetic resonance imaging in animal models of depression
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2015)Depression Is a debilitating and potentially fatal disorder for which the pathophysiology underlying the illness is still unknown. Aberrant glutamatergic neurotransmission and altered astrocyte function have recently been ... -
Neuronal Nitric oxide synthase : a novel target for antidepressant activity
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2012)Major depressive disorder (MDD) is one of the most common psychiatric disorders and its origin has been attributed to dysfunction of the monoamine systems, particularly noradrenergic and serotonergic, making them the main ... -
New solid forms of itraconazole and their pharmaceutical applications
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2020)Itraconazole (ITR) is an active pharmaceutical ingredient (API) with a broad-spectrum antifungal activity. This API has a very low solubility, which can hinder its bioavailability after oral administration. In this work, ... -
Nitrate-barbiburate compounds inhibit matrix metalloproteinase-9 in in-vitro and in-vivo models of intestinal inflammation
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2014)Inflammatory bowel disease is characterised by a dysregulated immune response and a compromised epithelial barrier. The enzyme matrix metalloproteinase-9 (MMP-9) is upregulated in an inflammatory setting and is believed ... -
Optimisation of pulmonary drug delivery of the model peptide drug, salmon calcitonin
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2011)The use of the pulmonary route is a viable alternative administration route to injection, in particular for drugs with poor systemic bioavailability upon oral delivery such as therapeutic peptides and proteins. However, ... -
Patterns of Medication Use Associated with Epilepsy and Comorbid Behavioural and Mental Disorders in Older People with Intellectual Disability
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2022)Background: There is increasing concern worldwide regarding the levels of use and suboptimal prescribing of psychotropic medication in people with intellectual disability. Antipsychotics, in particular are often prescribed ... -
Pharmaceutical cocrystals : a contribution to fundamental studies addressing solubility, dissolution, formation and characterisation
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2013)This thesis has focused on the study of pharmaceutical cocrystals. The investigations have addressed the solubility, dissolution and stability of cocrystals as well as the evaluation of selected production techniques, in ...
