Browsing Pharmacy and Pharmaceutical Sciences (Theses and Dissertations) by Title
Now showing items 59-78 of 156
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Formulation of protein and DNA microparticulate vaccine systems
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2003)This study involved investigation of protein and DNA-loaded microspheres manufactured with a range of polymers and under different manufacturing conditions. The polymers used during encapsulation were poly (lactide-co-glycolide) ... -
Formulation, production and biointeraction of micro and nano particulates with potential for use in drug delivery
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2009)The current study involved the preparation of a range of micro and nano particulates from known biocompatible pharmaceutical polymeric excipients: PLGA, chitosan and hyaluronic acid, using physical rather than chemical ... -
Functional expression of the epithelial sodium channel δ-subunit in human respiratory epithelial cells
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2012)Mammalian amiloride-sensitive epithelial Na+ channel (ENaC) can be composed by different combinations of four homologous subunits, α, β, γ and δ. The canonical αβγ- ENaC, abundantly expressed in Na+ absorbing epithelia, ... -
The Gut-Brain Axis in Inflammatory Bowel Disease: Assessment of the Central Inflammatory Response to Dextran Sulfate Sodium-Induced Colitis in Rats
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2018)Inflammatory bowel disease (IBD) is a chronic relapsing-remitting inflammatory condition of the gastrointestinal (GI) tract. Evidence indicates a comorbidity between IBD and psychological symptoms in patients. It is thought ... -
Hormonal and emotional regulation of memory processes
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2003)This thesis comprises two areas of study. The first study examined the effect of the menstrual cycle on Event-Related Potentials (ERPs) and verbal memory, as measured by paragraph recall and paired associates, and mood, ... -
Improving appropriate polypharmacy in older people in primary care
Introduction People are living longer but not necessarily in better health. The ageing population coupled with the increasing prevalence of chronic conditions has resulted in many older people being prescribed polypharmacy ... -
Influence of anti-inflammatory interventions in the Kainic acid model of hippocampal excitotoxicity
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2010)Excitotoxicity is implicated as a mechanism of neuronal cell death in a range of neurodegenerative disorders. Such toxicity can be induced experimentally by systemic administration of the glutamate kainate receptor agonist, ... -
Intestinal degradation and absorption kinetics of salmon calcitonin
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2000)The aim of this work was to investigate the intestinal degradation and absorption of a hydrophilic peptide, salmon calcitonin (sCT), and to evaluate the use of bile salt simple and mixed micellar systems as potential ... -
Intestinal lymphatic transport of DDT and Saquinavir : the role of lipid based formulations and modulators of P-Glycoprotein and Cytochrome P450
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2002)The experiments in this thesis represent biopharmaceutical investigations, performed in an attempt to evaluate potential dosage form strategies designed to promote the intestinal lymphatic transport of lipophilic compounds. ... -
Intestinal targeting of small molecule MMP and TGR5 ligands for inflammatory bowel disease
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2018)The aetiology of inflammatory bowel disease (IBD) is incompletely understood but it is generally accepted to involve a dysregulated intestinal immune response to commensal microbiota and an increase in intestinal permeability. ... -
Intracellular and extracellular biomarkers predictive of response to anti-cancer treatments for breast and prostate cancer
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2013)Cancer remains one of the leading causes of death worldwide. Breast and prostate cancer are the most frequently diagnosed cancers among women and men, respectively. Despite some breakthroughs in their treatment, innate or ... -
Investigating mechanisms of anti-cancer drug resistance in breast cancer cells and extracellular vesicles
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2019)Breast cancer is the most common female cancer diagnosed worldwide. In 2018 alone, there were over 2 million new breast cancer cases diagnosed. In Ireland, breast cancer is the most commonly diagnosed cancer in women. In ... -
Investigation into bile acid effects on the golgi apparatus, cell viability and glucocorticoid receptor distribution in esophageal cells
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2010)Bile acids are a family of steroidal molecules derived from cholesterol and biosynthesised in the pericentral hepatocytes in the liver. In recent years there has been a renaissance in bile acid based research as it has ... -
An investigation into the use of ion-exchange resins as a formulation approach for modified-release oral liquid preparations
(Trinity College Dublin, Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2022)This thesis focuses on the use of ion-exchange resins (IERs) to modify the release profile of an active pharmaceutical ingredient (API) that would help address an unmet clinical need in the population if formulated as an ... -
Investigation of cerebral perfusion changes following MDMA Ecstasy administration in an animal model using bolus-tracking arterial spin labelling MRI
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2012)The recreational drug of abuse 3,4 methylenedioxymethamphetamine (MDMA; Ecstasy) carries a risk of cerebrovascular accidents (CVA) that may relate to the role of serotonin (5- HT) and/or dopamine in the regulation of ... -
Investigation of factors affecting dissolution under biorelevant low velocity hydrodynamic conditions, using in vitro and in-silico methods
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2011)The goals of the current study were to investigate the effect of hydrodynamics on the dissolution of non-disintegrating compacts in a low velocity environment. This work also studies the impact of hydrodynamics on the ... -
Investigation of ibuprofen release from ethylcellulose matrix compacts
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2004)A comprehensive study of ethylcellulose powder and ethylcellulose compacts (of different ethylcellulose viscosity grades) was undertaken. Studies showed that the lower viscosity grade ethylcellulose (4 cP) was more ... -
Investigation of the PSD-95 / nNOS protein interaction as a target for antidepressant activity
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2013)Previous studies have demonstrated that nitric oxide (NO) synthase inhibitors are as efficacious as tricyclic antidepressants in preclinical antidepressant screening procedures and in attenuating behavioural deficits ... -
Investigation of the solid-state, powder flow and tabletability properties of comminuted active pharmaceutical ingredients
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2013)An understanding of the effect of processing on the solid-state properties of active pharmaceutical ingredients (APIs) is essential for product manufacturing success. During product development it is possible to induce ... -
Investigations into the anti allergy properties of novel benzocycloalkanone based compounds
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2010)An allergic response occurs because of a hypersensitive response by mast cells to an otherwise innocuous environmental substance. Allergen challenge causes mast cell degranulation, resulting in the release of mast cell ...