This thesis begins with a review of tumour growth and development, with a particular focus on angiogenesis. The numerous mechanisms which regulate the process are touched upon, with current and fiiture antiangiogenic agents ...

Over the last decade, the incidence of lung-related diseases such as asthma and chronic obstructive pulmonary disease and their associated morbidity have continuously risen. A heterogeneity in treatment response to commonly ...

Introduction People are living longer, but not necessarily in better health. The ageing population coupled with the rise in chronic conditions has led to many older people being prescribed polypharmacy, which may not always ...

Background: People with intellectual disabilities (ID) experience multi-morbidity, multiple medication use and have complex health needs. Gastrointestinal (GI) disorders such as constipation and gastroesophageal reflux ...

This study involved investigation of protein and DNA-loaded microspheres manufactured with a range of polymers and under different manufacturing conditions. The polymers used during encapsulation were poly (lactide-co-glycolide) ...

Mammalian amiloride-sensitive epithelial Na+ channel (ENaC) can be composed by different combinations of four homologous subunits, α, β, γ and δ. The canonical αβγ- ENaC, abundantly expressed in Na+ absorbing epithelia, ...

This thesis comprises two areas of study. The first study examined the effect of the menstrual cycle on Event-Related Potentials (ERPs) and verbal memory, as measured by paragraph recall and paired associates, and mood, ...

Excitotoxicity is implicated as a mechanism of neuronal cell death in a range of neurodegenerative disorders. Such toxicity can be induced experimentally by systemic administration of the glutamate kainate receptor agonist, ...

The experiments in this thesis represent biopharmaceutical investigations, performed in an attempt to evaluate potential dosage form strategies designed to promote the intestinal lymphatic transport of lipophilic compounds. ...

Cancer remains one of the leading causes of death worldwide. Breast and prostate cancer are the most frequently diagnosed cancers among women and men, respectively. Despite some breakthroughs in their treatment, innate or ...