Browsing Pharmacy and Pharmaceutical Sciences (Theses and Dissertations) by Title
Now showing items 39-58 of 156
-
Development and characterisation of a humanised model of Parkinson's disease associated with delivery of adeno-associated virus expressing alpha-synuclein and pre-formed alpha-synuclein fibrils unilaterally into the rat substantia nigra
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2022)Parkinson s disease (PD) is the most common motor neurodegenerative disease, characterised histologically by the presence of Lewy bodies, which are intracellular inclusions containing a variety of cellular proteins, the ... -
Development and evaluation of novel, personalisable electronic counselling aids for patients starting Direct Oral Anticoagulants (DOACs)
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2022)Comprehensive education for patients taking DOACs is essential to ensure treatment is safe and efficacious. The prescribing of DOACs has increased since becoming available on the European market in 2008, as evidence shows ... -
Development and preliminary evaluation of OPTI-3S: A deprescribing support tool for hospitalised frail older adults.
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2024)Introduction: In frail older people, polypharmacy (5 or more regular prescribed medicines) and the prescription of potentially inappropriate medicines (PIMs) are known to be prevalent and linked to negative clinical outcomes. ... -
Development of microemulsions and self-emulsifying systems for oral drug delivery
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2012)The main aim of the current work was to explore microemulsions (ME) and self- emulsifying lipid formulations (SELFs) comprising derivatives of capric/caprylic acids (Captex 355, Captex 200P, Capmul PG-8, Capmul MCM) as ... -
Development of new pharmacological agents for the treatment of T cell diseases of the skin
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2020) -
Development of salmon calcitonin (sCT) nanoporous / nanoparticulate microparticles for pulmonary delivery
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2013)The studies in this thesis focus on the development and production by spray drying of porous microparticulate systems designed for the pulmonary delivery of a therapeutic peptide - salmon calcitonin. The nanoporous/nanoparticulate ... -
Discovery of therapies for lymphomas and leukaemia: Synthesis and antiproliferative action of novel ethanoanthracenes
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2021)Cancer is a broad class of diseases responsible for up to 9.6 million deaths worldwide in 2018, accountable for approximately every one in six deaths globally. Cancer is second only in all-cause mortality to circulatory ... -
Drug transport across the human respiratory epithelial barrier
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2012)Drug transporters have only recently moved into the centre of attention of pulmonary drug delivery research, and of the more than 400 identified transporter proteins, only little information is available. In a first step, ... -
Effect of 2-amino imidazoline derivatives on tumour cell-induced platelet aggregation
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2020)Platelets play a central role in thrombosis and haemostasis. However, platelets can also aggregate in the presence of tumour cells in a phenomenon known as tumour-cell-induced-platelet-aggregation (TCIPA). During this ... -
Effect of hydrodynamics on dissolution rate of poorly soluble drugs in the flow through apparatus
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2009) -
Electronic Counselling for Oral Anticoagulant Patients
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2019)Education is an essential part of care for patients taking oral anticoagulants. However, it may be time-consuming for health care providers and overwhelming for patients, and hence sometimes suboptimal. Technology-based ... -
Enantioseparation and structural optimisation of b-lactams and stilbene analogues for the treatment of triple negative breast and chemoresistant colorectal cancers
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2023)Triple negative breast cancer (TNBC) is characterised by an extremely aggressive clinical phenotype and minimal expression of typical breast cancer receptors such as the estrogen, progesterone or HER2 receptors.1, 2 Patient ... -
Endothelium as a target in the design of novel tumour antiangiogenic / vasculature-targeting agents
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2008)This thesis begins with a review of tumour growth and development, with a particular focus on angiogenesis. The numerous mechanisms which regulate the process are touched upon, with current and fiiture antiangiogenic agents ... -
Engineering a novel insulin delivery system
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2013)The studies in this thesis investigated the preparation of a novel system that would be suitable for the oral delivery of insulin. The genetic modification of insulin gene to establish a simple system of insulin production ... -
Exploring Membrane Transporters in Lung Epithelial Cells: Drug-Transporter Interaction Analyses in Different In Vitro Models
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2023)Over the last decade, the incidence of lung-related diseases such as asthma and chronic obstructive pulmonary disease and their associated morbidity have continuously risen. A heterogeneity in treatment response to commonly ... -
Exploring population pharmacokinetic models in patients treated with vancomycin during continuous venovenous hemodiafiltration on different anticoagulant modalities
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2017)Uncertainty remains concerning pharmacokinetics (PK) of antimicrobials in critically ill patients due to the scarcity of data and the variable physiology of the patient cohort. This project incorporates two distinct aims. ... -
Exploring the potential impact of collaborative medicines optimisation involving pharmacogenomic testing and general practice pharmacists in primary care in Ireland
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, School of Pharmacy and Pharmaceutical Sciences, University of Dublin, Trinity College, 2024)Introduction People are living longer, but not necessarily in better health. The ageing population coupled with the rise in chronic conditions has led to many older people being prescribed polypharmacy, which may not always ... -
Factors affecting the stability and performance of amorphous solid dispersions of poorly soluble active pharmaceutical ingredients
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2020)This thesis focuses on factors affecting the stability and performance of amorphous solid dispersions (ASDs) of poorly soluble active pharmaceutical ingredients (APIs). The poor aqueous solubility of pipeline drugs has ... -
Factors associated with the use of gastrointestinal medicines amoung older people with intellectual disabilities in Ireland
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2020)Background: People with intellectual disabilities (ID) experience multi-morbidity, multiple medication use and have complex health needs. Gastrointestinal (GI) disorders such as constipation and gastroesophageal reflux ... -
Formulation and characterisation of polyelectrolyte complex nanoparticles for the delivery of salmon calcitonin
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2013)The studies in this thesis explored the formulation of various polyelectrolyte complex nanoparticles as potential carriers for the delivery of macromolecules. The complexes were formed between a polyanion (hyaluroninc acid, ...
