Browsing Pharmacy and Pharmaceutical Sciences (Theses and Dissertations) by Title
Now showing items 27-46 of 156
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Chemistry and Biology studies on anti-inflammiatory bile acid derivatives
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2019)Abstract The objective of the dissertation is to clarify the potency, cytotoxicity and metabolism of novel steroidal anti-inflammatory compounds in the treatment inflammatory bowel disease (IBD). Biochemical methods with ... -
A Comparison of Spray drying and Liquid Antisolvent Co-precipitation for the Generation of Two- and Three- component Amorphous Solid Dispersions
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2024)The thesis focuses on the use of different manufacturing techniques for the generation of amorphous solid dispersions (ASDs) for the enhancement of the solubility of model compounds. ASDs with hydrochlorothiazide (HCTZ) ... -
Costs and outcomes of cancer care in older adults : population-based analysis
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2014)Cancer is a major cause of mortality worldwide. The disease disproportionately affects the older population and 60% of new cancer cases and 70% of cancer-related deaths occur in individuals aged 65 or older. Large national ... -
Cytokine-induced epithelial-mesenchymal transition : mechanisms and implications for fibrotic diseases of respiratory and intestinal epithelia
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2010)Fibrosis is characterised by the accumulation of myofibroblasts, the key effector cell implicated in the fibrogenic reaction. The exact origin of these myofibroblasts remains poorly understood. However, growing evidence ... -
Deciphering the interplay of extracellular vesicles and drug resistance in HER2-positive breast cancer: insights, biomarkers and therapeutic implications
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2023)According to a World Health Organisation (WHO) report on 3rd March 2021, breast cancer is the most common form of cancer in the world and the leading cause of cancer death among females. In 2020, 2.26 million newly breast ... -
Deprescribing Falls Risk Increasing Drugs in Older Adults
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2023)Aim: The purpose of this thesis was to examine the facilitators of, and barriers to, implementing deprescribing of falls risk increasing medicines (FRIDs) in healthcare professionals' practices, by exploring the perspectives ... -
Design and biological activity of a novel bioactive indane scaffold
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2015)This project is focussed on the design, synthesis and pharmacological evaluation of novel drug-hybrids which combine anti-inflammatory and anti-tumour activities to target the interface between inflammatory disease and ... -
Design and development of a hydrogel formulation with nanoparticles for the treatment of glioblastoma multiforme
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2021)Glioblastoma multiforme (GBM) is the most aggressive form of brain tumours. GBM treatment is challenging because tumours are highly invasive and it is difficult to achieve effective therapeutic doses of drugs into the ... -
Design and synthesis of tubulin-binding agents, and their incorporation into novel dual-acting hybrid molecules targeting the tumour vasculature
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2013)This thesis involves the design and synthesis of tubulin binding agents, which aside from their anti-proliferative impact, seek to induce anti-vascular and anti-angiogenic responses on the unique vasculature derived by a ... -
Design, Synthesis and biochemical evaluation of novel anthracenes, ethanoanthracenes and related compounds to target Burkitt's Lymphoma
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2015)Burkitt's lymphoma is an aggressive non-Hodgkin lymphoma occurring with high incidence in developing areas such as equatorial Africa and Papua New Guinea. Within these tropical regions of high incidence (40-50 per 10 6), ... -
Design, synthesis and evaluation of indazoles as antiproliferative agents
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2015)Cancer is a leading cause of death in most countries, second only to the diseases of the circulatory system. In relation to Ireland, cancer accounted for 29.6 % of all the deaths reported in 2012. After non-melanoma skin ... -
Design, synthesis and evaluation of novel tumour vasculature-targeting agents
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2007)This thesis is introduced with a review of the 'Hallmarks of Cancer', outlining each one as a potential target for drug therapy. Vascular targeting as a means of cancer growth retardation is specifically discussed. The ... -
Development and characterisation of a humanised model of Parkinson's disease associated with delivery of adeno-associated virus expressing alpha-synuclein and pre-formed alpha-synuclein fibrils unilaterally into the rat substantia nigra
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2022)Parkinson s disease (PD) is the most common motor neurodegenerative disease, characterised histologically by the presence of Lewy bodies, which are intracellular inclusions containing a variety of cellular proteins, the ... -
Development and evaluation of novel, personalisable electronic counselling aids for patients starting Direct Oral Anticoagulants (DOACs)
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2022)Comprehensive education for patients taking DOACs is essential to ensure treatment is safe and efficacious. The prescribing of DOACs has increased since becoming available on the European market in 2008, as evidence shows ... -
Development and preliminary evaluation of OPTI-3S: A deprescribing support tool for hospitalised frail older adults.
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2024)Introduction: In frail older people, polypharmacy (5 or more regular prescribed medicines) and the prescription of potentially inappropriate medicines (PIMs) are known to be prevalent and linked to negative clinical outcomes. ... -
Development of microemulsions and self-emulsifying systems for oral drug delivery
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2012)The main aim of the current work was to explore microemulsions (ME) and self- emulsifying lipid formulations (SELFs) comprising derivatives of capric/caprylic acids (Captex 355, Captex 200P, Capmul PG-8, Capmul MCM) as ... -
Development of new pharmacological agents for the treatment of T cell diseases of the skin
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2020) -
Development of salmon calcitonin (sCT) nanoporous / nanoparticulate microparticles for pulmonary delivery
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2013)The studies in this thesis focus on the development and production by spray drying of porous microparticulate systems designed for the pulmonary delivery of a therapeutic peptide - salmon calcitonin. The nanoporous/nanoparticulate ... -
Discovery of therapies for lymphomas and leukaemia: Synthesis and antiproliferative action of novel ethanoanthracenes
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2021)Cancer is a broad class of diseases responsible for up to 9.6 million deaths worldwide in 2018, accountable for approximately every one in six deaths globally. Cancer is second only in all-cause mortality to circulatory ... -
Drug transport across the human respiratory epithelial barrier
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2012)Drug transporters have only recently moved into the centre of attention of pulmonary drug delivery research, and of the more than 400 identified transporter proteins, only little information is available. In a first step, ...
