Browsing Pharmacy and Pharmaceutical Sciences (Theses and Dissertations) by Title
Now showing items 139-156 of 156
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The influence of drug physicochemical properties on release from thermoresponsive smart hydrogels
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2005)Thermoresponsive hydrogels are a class of "smart" or "environmentally sensitive" systems with potential for controlling the release of a drug in response to a specific stimulus. Previous research in the area of thermoresponsive ... -
The optimisation, characterisation and platelet compatibility of polymeric nanocarriers loaded with NSAIDs
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2014)There is a constant drive towards improving global health by continuously enhancing the quality of drugs available and the systems to deliver these drugs efficiently in order to treat disease. This thesis focused on the ... -
The pharmacological and toxicological effects of polystyrene and silica nanoparticles on human airway epithelial cells
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2010)Background and purpose: A number of lung pathologies are associated with the dysfunction of ion flux through pulmonary epithelium. Cystic fibrosis (CF) is a chronic and life-threatening genetic disease that directly affects ... -
The pharmacological effects of novel isosorbide-based butyrylcholinesterase inhibitors
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2009)This study sought to determine the pharmacological effects of novel isosorbide-based butyrylcholinesterase inhibitors (BuChEl’s) in vitro and in vivo. The potency of the novel compounds 2-benzylcarbamate 5-nicotinate ... -
The production and characterisation of spray dried nanoporous microparticles (NPMPs) intended for dry powder inhalation drug delivery systems
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2008)The focus of the research presented in this thesis was on the potential application of a novel spray drying method to produce excipient-free nanoporous microparticles (NPMPs) of bioactive drug compounds and co-spray dried ... -
The role of the community pharmacist in optimising patients' inhaler use in asthma management
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2013)The Asthma Insights and Reality in Ireland survey revealed that only 8% of those surveyed had controlled asthma, as defined by evidence-based guidelines. A detailed analysis of patients’ abilities to use their inhalation ... -
The specialist pharmacist and quality indicators of medication use in the care of people with intellectual disabilities and behaviour disorders
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2016)Quality Medication Use and the Population with Intellectual Disabilities and Behaviour Disorders. A Modified Delphi Technique to develop Quality Indicators and a Grounded Theory approach to information provided by people ... -
The synthesis and biological evaluation of a novel class of butyrylcholinesterase inhibitors using isosorbide as a building block
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2007)The aim of this project was to synthesise and optimise a novel class of cholinesterase inhibitors using the simple sugar, isosorbide, as a building block and to assess the inhibitory activity of these compounds in vitro. ... -
The synthesis of novel mast cell stabilisers from benzocycloalkanones
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2010)The purpose of this project was to design and synthesise novel classes of mast cell stabilisers from benzocycloalkanones. This thesis is introduced with an overview of the increasing prevalence of allergic conditions ... -
A theory-based exploration of the medicines management process provided to older people residing in the nursing home setting in the Republic of Ireland
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2023)Introduction While the population is ageing globally, this does not necessarily mean that they are living healthier. The multimorbidity and polypharmacy in the older population (age> 65 years) increases their risk of ... -
Traditional Medicinal Knowledge documented in the Schools Manuscript Collection: An insight into the medical beliefs, practices and healing plants used in 1930s Ireland.
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2022)The National Folklore Collection (NFC) in University College Dublin holds one of the largest collections of ethnographic material globally. In 2017, the Irish Folklore Commission Collection (1935-1970), housed within the ... -
The treatment of obesity using magneto -mechanical effect
Obesity is a very prevalent condition that can be very often associated with the development of comorbidities, such as insulin resistance, hypertension, and hyperlipidaemia that can lead to cardiovascular and cerebrovascular ... -
Triple negative breast cancer-derived extracellular-vesicles as naturally-occuring biomarkers and therapeutic delivery systems
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2015)Background: In Ireland, breast cancer is the most commonly diagnosed cancer among women; and of the breast cancer subtypes, triple-negative breast cancers (TNBC) are the most aggressive. TNBCs account for 15%-20% of breast ... -
Tumour microenvironment, extracellular vesicles and their effect on prostate cancer progression and docetaxel resistance
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2022)Prostate cancer is the fourth most common cancer in Europe and the third leading cause of death in males. The standard of care as initial treatment for prostate cancer is, typically, androgen-deprivation therapy. Although ... -
Understanding the role of low glass transition temperature excipients in the mitigation of amorphisation on mechanical processing
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2017)Commonly employed pharmaceutical processes such as milling, blending and compaction may unintentionally lead to the generation of amorphous regions or metastable polymorphic forms in crystalline active pharmaceutical ... -
Use of computational fluid dynamics to investigate the relationship between hydrodynamics and rates of dissolution
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2007)The hydrodynamics within the paddle (900 ml), basket (900 ml) and Levy beaker (350 ml and 550 ml) (Levy et al., 1965) dissolution apparatuses were simulated using the computational fluid dynamics (CFD) package, Fluent™. ... -
Using in vitro and in silico approaches to investigate ibuprofen particulate and formulation dissolution behaviour under different hydrodynamic conditions.
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2024)This work investigated the effect of fluid velocity and medium viscosity on the dissolution of ibuprofen powder and ibuprofen immediate release tablets in vitro, in the paddle apparatus and the flow-through apparatus, and ... -
Warfarin therapy in the Republic of Ireland : the potential role of neural networks in optimising therapy
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2002)Anticoagulant therapy is used to reduce the embolic risk associated with many diseases e.g. atrial fibrillation, deep vein thrombosis and aortic valve replacement. The decision to anticoagulate a patient is made individually, ...
