Browsing Pharmacy and Pharmaceutical Sciences (Theses and Dissertations) by Title
Now showing items 111-130 of 156
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Preparation and characterisation of spray dried composites of pharmaceutical materials
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2003)The solid state properties of a range of spray dried excipients and drugs and co-spray dried excipient/excipient, drug/excipient and drug/drug, systems were investigated. The excipients investigated were lactose, polyethylene ... -
Preparation of cocrystal-in-excipient systems by advanced pharmaceutical methods
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2019)This thesis focuses on the production of cocrystal-in-excipient systems by a variety of advanced pharmaceutical methods, such as spray drying, hot melt extrusion and spray coating. The production of cocrystal-in-excipient ... -
Prevalence, patterns and factors associated with multiple medicines use in an ageing poulation with intelletual disability in Ireland
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2015)The provision of rational and appropriate pharmacotherapy to older people with intellectual disabilities (ID) poses significant challenges due to the complexities of conditions being treated, the increased risks of adverse ... -
The production and characterisation of itraconazole multicomponent systems
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2019)This thesis focuses on the poorly soluble triazole antifungal agent, itraconazole (ITZ). This compound was reported to form hydrochloride salts and cocrystals with a wide range of aliphatic dicarboxylic acids, which have ... -
Production and characterisation of spray dried particulate systems for pulmonary drug delivery
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2009)The work presented in this thesis concerns the application of a particle engineering technology, one-step spray drying method, to produce porous particles of antitubercular drugs, suitable for inhalation and to study the ... -
The production and characterization of fluoroquinolone amorphous solid dispersions
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2017)Ciprofloxacin (CIP) is a Biopharmaceutics Classification System class 4 drug, which exhibits solid-state limited solubility. Among the different formulation options available to improve the solubility of such a compound, ... -
The production of crystalline powders by spray drying to improve the mechanical and flow properties of an active pharmaceutical ingredient
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2020)The overall aim of this research was to crystallise a drug onto the surface of an excipient (EXP) using a spray dryer in order to improve the processability of the attached active pharmaceutical ingredient (API). The project ... -
The production, characterisation, stabilization and isolation of azole anti-fungal nanoparticles
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2019)In this work, the effect of stabilizer choice and concentration was investigated on nanoparticle (NP) stability over time. Three different BCS class II active pharmaceutical ingredients (APIs): itraconazole (ITR), ketoconazole ... -
RBL-2H3 and primary mast cells and their use in screening novel anti-inflammatory compounds
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2009)Mast cells (MC) have been mainly studied as key effectors in allergic diseases and inflammatory conditions such hypersensitivity reactions, asthma, atopic dermatitis and multiple sclerosis. Following the crosslinkage of ... -
The role of community pharmacists in disease prevention: A study of the delivery of clinical pharmacy services in community pharmacy in Ireland
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2018)The Role of Community Pharmacists in Disease Prevention: A Study of the Delivery of Clinical Pharmacy Services in Community Pharmacy in Ireland Susan O Dwyer Aims The overall aim of this research was to explore the role ... -
Role of kynurenine on platelet's function and beyond
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2020)Kynurenine is a metabolite of the amino acid tryptophan by the action of the tryptophan dioxygenase enzyme in the liver and the ubiquitous indolamine dioxygenase enzyme in other tissues. Although it has been shown that ... -
A Scientific Evaluation of Traditional Chinese Medicine (TCM): Houttuynia cordata Thunb Saururaceae - A Case Study
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2021)Traditional Chinese Medicine (TCM) is one of the oldest medical systems in the world, still used for prevention or treatment of diseases in the modern China. It is a unique and holistic system, guided by ancient Chinese ... -
Simulations of hydrodynamics in the paddle dissolution apparatus and dissolution from multi-layered compacts
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2003)Studies involving the calculation of dissolution rates from individual surfaces of large single component compacts, to assist in the prediction of dissolution rates from simple layered compact systems, revealed that ... -
Solid-state characteristics of pre- and post-spray dried active pharmaceutical ingredients, salts and co-crystalline forms
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2011)Salt or co-crystal formation is one of the methods of altering the physicochemical properties of an active pharmaceutical ingredient (API). The drug characteristic can also be changed upon processing. This thesis focused ... -
Stereoselective synthesis of novel tubulin inhibitors with diverse functionality for integration into molecular conjugates and designed multiple ligands
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2013)The principal objective of the work described in this thesis was the synthesis of a series of novel tubulin inhibitors, with defined stereochemistry and diverse functionality, suitable for the formation of molecular ... -
Studies on the design, synthesis and stability of novel anti-allergy agents
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2012)The purpose of this project was to design and synthesise novel classes of anti-allergy compounds using 1-tetralone as the principal building block. This thesis is introduced with an overview of the prominent role played ... -
A study of glial associated changes in the complexity of primary cortical neurons
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2021)Neuroinflammation and disruptions in the integrity of neuronal circuitry are hallmarks of a range of CNS disorders. There is extensive evidence linking pro-inflammatory signalling and glial dysfunction with neuronal atrophy ... -
Synthesis of Tubulin Inhibitors with Variable Molecular Hinges for the Attachment of Aminopeptidase N Targeting Moieties
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2019)This thesis includes synthesis of various tubulin binding agents and their incorporation in to novel dual acting hybrids, which along with the tubulin inhibition also exhibit aminopeptidase N (APN) inhibition activities. This ... -
Synthesis, characterisation and drug release from a range of novel smart co-biodegrable delivery systems
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2008)In recent years many biodegradable polymers have been investigated particularly for controlled delivery of drugs or proteins/peptides. The most commonly studied biodegradable polymers for controlled drug delivery are based ... -
Synthetic amorphous silica nanoparticles induce human endothelial cell inflammation and platelet aggregation : role of NF-kB and reactive nitrogen species
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2010)Background and purpose: The human population has been exposed to nanoparticles (particles with nano-dimensions) throughout all its evolutionary process; however, this exposure has been increased since the industrial ...
