Browsing Pharmacy and Pharmaceutical Sciences (Theses and Dissertations) by Title
Now showing items 106-125 of 156
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Phytochemical studies on Choisya x dewitteana 'Aztec Pearl'
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2018)The thesis is introduced with a review of the genus Choisya. Here emphasis is placed on the botany, traditional uses, phytochemistry and ethnopharmacological studies. The main classes of compounds found in the genus are ... -
Platelets decrease chemotherapy -induced cancer cell damage by increasing cell survival : mechanisms and significance
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2010)Cancer cells grow without the restraints of feedback control mechanisms that regulate normal tissue or organ growth, such as apoptosis, leading to Increased cancer cell survival. Deregulation of apoptosis has been Implicated ... -
Polyamines and polyamine antagonists in cerebral ischaemia
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2005)Polyamines are ubiquitous components of all eukaryotic cells and are found in brain tissue. A number of studies have shown that changes in the levels of polyamines occur following cerebral ischaemia. However, whether ... -
A Precision Medicine Approach to Natriuretic Peptide-Guided Risk Prediction and Treatment: A Retrospective Analysis in the STOP-HF Cohort
Introduction: Individual studies show that NP-guided treatment is an effective intervention for the prevention of HF. We hypothesised that this approach may be optimised utilising a precision medicine approach. Methods: ... -
Preclinical evaluation of novel tumour vasculature disrupting agents
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2013)Targeting of tumour vasculature and angiogenesis represents an ideal approach in the design of cancer therapeutics since all types of solid tumours are dependent upon a blood supply for growth and survival. The best known ... -
Preparation and characterisation of spray dried composites of pharmaceutical materials
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2003)The solid state properties of a range of spray dried excipients and drugs and co-spray dried excipient/excipient, drug/excipient and drug/drug, systems were investigated. The excipients investigated were lactose, polyethylene ... -
Preparation of cocrystal-in-excipient systems by advanced pharmaceutical methods
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2019)This thesis focuses on the production of cocrystal-in-excipient systems by a variety of advanced pharmaceutical methods, such as spray drying, hot melt extrusion and spray coating. The production of cocrystal-in-excipient ... -
Prevalence, patterns and factors associated with multiple medicines use in an ageing poulation with intelletual disability in Ireland
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2015)The provision of rational and appropriate pharmacotherapy to older people with intellectual disabilities (ID) poses significant challenges due to the complexities of conditions being treated, the increased risks of adverse ... -
The production and characterisation of itraconazole multicomponent systems
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2019)This thesis focuses on the poorly soluble triazole antifungal agent, itraconazole (ITZ). This compound was reported to form hydrochloride salts and cocrystals with a wide range of aliphatic dicarboxylic acids, which have ... -
Production and characterisation of spray dried particulate systems for pulmonary drug delivery
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2009)The work presented in this thesis concerns the application of a particle engineering technology, one-step spray drying method, to produce porous particles of antitubercular drugs, suitable for inhalation and to study the ... -
The production and characterization of fluoroquinolone amorphous solid dispersions
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2017)Ciprofloxacin (CIP) is a Biopharmaceutics Classification System class 4 drug, which exhibits solid-state limited solubility. Among the different formulation options available to improve the solubility of such a compound, ... -
The production of crystalline powders by spray drying to improve the mechanical and flow properties of an active pharmaceutical ingredient
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2020)The overall aim of this research was to crystallise a drug onto the surface of an excipient (EXP) using a spray dryer in order to improve the processability of the attached active pharmaceutical ingredient (API). The project ... -
The production, characterisation, stabilization and isolation of azole anti-fungal nanoparticles
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2019)In this work, the effect of stabilizer choice and concentration was investigated on nanoparticle (NP) stability over time. Three different BCS class II active pharmaceutical ingredients (APIs): itraconazole (ITR), ketoconazole ... -
RBL-2H3 and primary mast cells and their use in screening novel anti-inflammatory compounds
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2009)Mast cells (MC) have been mainly studied as key effectors in allergic diseases and inflammatory conditions such hypersensitivity reactions, asthma, atopic dermatitis and multiple sclerosis. Following the crosslinkage of ... -
The role of community pharmacists in disease prevention: A study of the delivery of clinical pharmacy services in community pharmacy in Ireland
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2018)The Role of Community Pharmacists in Disease Prevention: A Study of the Delivery of Clinical Pharmacy Services in Community Pharmacy in Ireland Susan O Dwyer Aims The overall aim of this research was to explore the role ... -
Role of kynurenine on platelet's function and beyond
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2020)Kynurenine is a metabolite of the amino acid tryptophan by the action of the tryptophan dioxygenase enzyme in the liver and the ubiquitous indolamine dioxygenase enzyme in other tissues. Although it has been shown that ... -
A Scientific Evaluation of Traditional Chinese Medicine (TCM): Houttuynia cordata Thunb Saururaceae - A Case Study
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2021)Traditional Chinese Medicine (TCM) is one of the oldest medical systems in the world, still used for prevention or treatment of diseases in the modern China. It is a unique and holistic system, guided by ancient Chinese ... -
Simulations of hydrodynamics in the paddle dissolution apparatus and dissolution from multi-layered compacts
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2003)Studies involving the calculation of dissolution rates from individual surfaces of large single component compacts, to assist in the prediction of dissolution rates from simple layered compact systems, revealed that ... -
Solid-state characteristics of pre- and post-spray dried active pharmaceutical ingredients, salts and co-crystalline forms
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2011)Salt or co-crystal formation is one of the methods of altering the physicochemical properties of an active pharmaceutical ingredient (API). The drug characteristic can also be changed upon processing. This thesis focused ... -
Stereoselective synthesis of novel tubulin inhibitors with diverse functionality for integration into molecular conjugates and designed multiple ligands
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2013)The principal objective of the work described in this thesis was the synthesis of a series of novel tubulin inhibitors, with defined stereochemistry and diverse functionality, suitable for the formation of molecular ...
