Browsing Pharmacy and Pharmaceutical Sciences (Theses and Dissertations) by Title
Now showing items 1-20 of 156
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A novel method for the measurement of flow-induced platelet activation at nanoscale resolution level
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2009)Background: Platelet aggregation Is essential for vascular haemostasis and thrombosis. Inhibition of platelet aggregation underpins the pharmacological and clinical effects of antiplatelet drugs. These effects are commonly ... -
A pharmacokinetic and clinical evaluation of antimicrobial drugs in critically ill patients during Continuous Venovenous Haemodifiltration (CVVHDF) therapy
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2007)Critically ill patients are at risk from sepsis requiring antimicrobial therapy and acute renal failure, which may require extracorporeal renal replacement therapy. The objective of this study was to quantify and assess ... -
A study of the release of the amphoteric drug amoxycillin from biodegradable polymers
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2000)Poly-alpha-hydroxy-aliphatic esters constitute a group of biodegradable polymers which have been actively investigated over the past three decades for the sustained release of drug compounds. A literature review revealed ... -
Absorption properties of non-steroidal anti-inflammatory drugs and their amino acid derivatives
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2003)The principal objectives of this work were: i) to examine the absorption properties of ibuprofen in a range of different buffer solutions; ii) to study the absorption properties and mechanisms of ibuprofen, ketoprofen and ... -
Addressing the complexity of medication use in older people with intellectual disability
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2019)Background: People with intellectual disabilities (ID) experience high levels of polypharmacy and medication burden. Many of the most commonly occurring medical conditions in older adults with ID are treated with medications ... -
An exploration of the role of community pharmacists in health promotion in Ireland
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2009)A combination of qualitative and quantitative methodologies was used to explore the research questions from a number of different angles. A literature review was carried out to identify work which had already been published ... -
An exploration of the role of community pharmacists in the supply of benzodiazepines and Z-drugs in Ireland
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2014)This thesis set out to explore community pharmacists' role in the supply of benzodiazepines and Z-drugs in Ireland. The introductory chapter outlines how the research undertaken sought to address a notable gap in the ... -
An investigation into the behavioural effects of polyamines, polyamine antagonsits and novel compounds in vivo
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2007)The polyamines, putrescine, spermidine and spermine are ubiquitous compounents of eukaryotric cells in nature and are found in high concentrations in brain tissue. Polyamines have been implicated in cell growth, differentiation ... -
An investigation into the effects of current immunosuppressants and novel compounds on animal models of asthma and delayed type hypersensitivity
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2007)Asthma is a disease with a worldwide distribution and of increasing prevalence. There are two forms of the disease; intrinsic, which is believed to follow a Th1 cytokine profile and extrinsic, which follows a Th2 response. ... -
An investigation of the impact of experimental colitis and inflammatory bowel disease on behaviour and on systemic and central inflammation
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2013)Inflammatory bowel diseases (IBD) are chronic conditions characterised by uncontrolled inflanmiation of the intestinal mucosa. Clinical symptoms include weight loss, diarrhoea, rectal bleeding and abdominal pain. In addition ... -
An investigation of the potential anti-inflammatory properties of novel compounds with respect to LFA-1 mediated T cell motility and cytotoxicity profiling
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2009)The aim of this thesis was to investigate the effects in vitro of novel compounds on LFA-1 mediated T cell motility, and, to develop a profile of the compounds with respect to cytotoxicity and apoptosis. The compounds ... -
An investigation of the role of the polyamines in epilepsy and cerebral ischaemia
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2001)The polyamines, spermine and spermidine, are ubiquitous in nature but are found in especially high concentrations in brain tissue. The polyamines are required for cell growth and differentiation but in high doses are ... -
An investigation on the therapeutic properties of novel compounds in models of asthma, inflammation and delayed type hypersensitivity
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2000)There are many drugs on the market for the treatment of asthma, inflammation and delayed type hypersensitivity (DTH), however few are disease modifying. The potential therapeutic effect of three novel compounds, 3C8, 6C6 ... -
An investigation to optimise teicoplanin therapy in patients with haematological malignancy and Gram-positive infection
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2016)This research was prompted by concerns of Tallaght Hospital, a major teaching hospital in Dublin, Ireland, that the dosage regimen for teicoplanin in patients with haematological malignancy was suboptimal. Three studies ... -
Approaches to Drying Hydrated Active Pharmaceutical Ingredients (APIs).
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2023)This project aims to develop a drying protocol that removes unwanted moisture from hydrated APIs while preserving water of hydration. Hydrate forms of model compounds, carbamazepine and theophylline, were generated with ... -
Assessment of milk extracellular vesicle (EV) in vitro bioactivity
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, School of pharmacy and pharmaceutical science, 2024)Extracellular Vesicles (EVs) are small particles involved in cell-to-cell communication. They have been identified in numerous biological fluids, including milk. Milk EVs serve to communicate between mother and infant, ... -
Assessment of permeability enhancers for salmon calcitonin (sCT) across intestinal cell culture models
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2000)A large number of proteins are now being used or tested as therapeutic agents, enzyme inhibitors or antibodies to combat human disease, therefore they are receiving increased recognition for both their high activity at low ... -
Blood biocompatiblity of polyvinyl, chloride surface-modified with multi-walled carbon nanotubes
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2012)Blood-surface interaction in extracorporeal circuits (for example, cardiopulmonary bypass) requires the infusion of a systemic anticoagulant to prevent devastating thrombus formation. Platelet activation upon contact with ... -
C6 glioma neuronal interactions and their moderation by the tryptophan-kynurenine metabolism pathway
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2021)Brain glia possess the rate limiting enzyme indoleamine 2, 3-dioxygenase (IDO) which catalyses the conversion of tryptophan to kynurenine. Microglia also express kynurenine monooxygenase (KMO) and kynureninase (KYNU) which ... -
Caffeine exacerbates the toxicity of 3,4 methylenedioxymethamphetamine (MDMA, Ecstasy ) : a role for dopamine
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2010)Co-administration of caffeine profoundly enhances the acute toxicity of the substituted amphetamine 3, 4-methylenedioxymethamphetamine (MDMA “Ecstasy”) in rats, evidenced by high body temperature, tachycardia and increased ...
