Browsing Pharmacy and Pharmaceutical Sciences (Theses and Dissertations) by Title
Now showing items 19-38 of 156
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C6 glioma neuronal interactions and their moderation by the tryptophan-kynurenine metabolism pathway
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2021)Brain glia possess the rate limiting enzyme indoleamine 2, 3-dioxygenase (IDO) which catalyses the conversion of tryptophan to kynurenine. Microglia also express kynurenine monooxygenase (KMO) and kynureninase (KYNU) which ... -
Caffeine exacerbates the toxicity of 3,4 methylenedioxymethamphetamine (MDMA, Ecstasy ) : a role for dopamine
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2010)Co-administration of caffeine profoundly enhances the acute toxicity of the substituted amphetamine 3, 4-methylenedioxymethamphetamine (MDMA “Ecstasy”) in rats, evidenced by high body temperature, tachycardia and increased ... -
Characterisation of Depressive Symptoms in Huntington's Disease and of the Pharmacological Treatment for Depression: patterns, trends and Statistical Analysis of Enroll-HD Dataset
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2022)Background: Huntington?s Disease (HD) is a rare autosomal dominant genetic disorder characterised by a triad of motor, psychiatric and cognitive symptoms. Among the psychiatric manifestations, depression is very common and ... -
Characterisation of drug transporters in human respiratory epithelial cells
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2010)Cell culture models are an efficient and relatively cheap tool to study isolated mechanisms of an organ. The right cell model, carefully selected to allow highest benefits, can give valuable information in the area of ... -
Characterisation of drug-fatty acid composites and their use in drug delivery systems
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2000)Fatty acids are considered to be useful as carrier materials in the formulation of drug delivery systems. Literature on fatty acid systems, in particular, stearic acid, was reviewed, though in general, research in this ... -
Characterisation of polymorphisms on the promoter region of the human histamine 4 receptor
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2013)The human histamine 4 receptor (HRH4) is the recently discovered receptor in the histamine GPCR family. It is mainly expressed in haematopoietic cells but recent publications provide evidence that it is both expressed and ... -
Characterisation of the functional role of OCTN1 in the pathogenesis of COPD
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2018)The organic cation transporter (OCTN1) has been reported to play a role in the pathogenesis and development of inflammatory diseases. However, this association remains conflicting. Without fully elucidating the physiological ... -
Chemical biology studies on human and mouse secondary bile acids
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2022)Bile acids are important regulators of multiple homeostatic mechanisms integrating cell proliferation, metabolism and inflammation. The overall objective of this thesis was to use chemical biology tools to understand ... -
Chemistry and Biology studies on anti-inflammiatory bile acid derivatives
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2019)Abstract The objective of the dissertation is to clarify the potency, cytotoxicity and metabolism of novel steroidal anti-inflammatory compounds in the treatment inflammatory bowel disease (IBD). Biochemical methods with ... -
A Comparison of Spray drying and Liquid Antisolvent Co-precipitation for the Generation of Two- and Three- component Amorphous Solid Dispersions
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2024)The thesis focuses on the use of different manufacturing techniques for the generation of amorphous solid dispersions (ASDs) for the enhancement of the solubility of model compounds. ASDs with hydrochlorothiazide (HCTZ) ... -
Costs and outcomes of cancer care in older adults : population-based analysis
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2014)Cancer is a major cause of mortality worldwide. The disease disproportionately affects the older population and 60% of new cancer cases and 70% of cancer-related deaths occur in individuals aged 65 or older. Large national ... -
Cytokine-induced epithelial-mesenchymal transition : mechanisms and implications for fibrotic diseases of respiratory and intestinal epithelia
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2010)Fibrosis is characterised by the accumulation of myofibroblasts, the key effector cell implicated in the fibrogenic reaction. The exact origin of these myofibroblasts remains poorly understood. However, growing evidence ... -
Deciphering the interplay of extracellular vesicles and drug resistance in HER2-positive breast cancer: insights, biomarkers and therapeutic implications
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2023)According to a World Health Organisation (WHO) report on 3rd March 2021, breast cancer is the most common form of cancer in the world and the leading cause of cancer death among females. In 2020, 2.26 million newly breast ... -
Deprescribing Falls Risk Increasing Drugs in Older Adults
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2023)Aim: The purpose of this thesis was to examine the facilitators of, and barriers to, implementing deprescribing of falls risk increasing medicines (FRIDs) in healthcare professionals' practices, by exploring the perspectives ... -
Design and biological activity of a novel bioactive indane scaffold
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2015)This project is focussed on the design, synthesis and pharmacological evaluation of novel drug-hybrids which combine anti-inflammatory and anti-tumour activities to target the interface between inflammatory disease and ... -
Design and development of a hydrogel formulation with nanoparticles for the treatment of glioblastoma multiforme
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2021)Glioblastoma multiforme (GBM) is the most aggressive form of brain tumours. GBM treatment is challenging because tumours are highly invasive and it is difficult to achieve effective therapeutic doses of drugs into the ... -
Design and synthesis of tubulin-binding agents, and their incorporation into novel dual-acting hybrid molecules targeting the tumour vasculature
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2013)This thesis involves the design and synthesis of tubulin binding agents, which aside from their anti-proliferative impact, seek to induce anti-vascular and anti-angiogenic responses on the unique vasculature derived by a ... -
Design, Synthesis and biochemical evaluation of novel anthracenes, ethanoanthracenes and related compounds to target Burkitt's Lymphoma
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2015)Burkitt's lymphoma is an aggressive non-Hodgkin lymphoma occurring with high incidence in developing areas such as equatorial Africa and Papua New Guinea. Within these tropical regions of high incidence (40-50 per 10 6), ... -
Design, synthesis and evaluation of indazoles as antiproliferative agents
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2015)Cancer is a leading cause of death in most countries, second only to the diseases of the circulatory system. In relation to Ireland, cancer accounted for 29.6 % of all the deaths reported in 2012. After non-melanoma skin ... -
Design, synthesis and evaluation of novel tumour vasculature-targeting agents
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2007)This thesis is introduced with a review of the 'Hallmarks of Cancer', outlining each one as a potential target for drug therapy. Vascular targeting as a means of cancer growth retardation is specifically discussed. The ...
