Oral Medicine (Theses and Dissertations)
Recent Submissions
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Comparative molecular characterisation of community and healthcare-associated Panton-Valentine leukocidin-positive Staphylococcus aureus and S. aureus from bloodstream infections in Ireland
(Trinity College (Dublin, Ireland). School of Dental Science, 2016)Staphylococcus aureus is one of the most frequently isolated bacterial pathogens from healthcare- and community associated infections (HCA and CA, respectively) worldwide and is a serious burden for patients and the ... -
Healthcare environmental reservoirs of infection : investigating water systems and the use of electrochemically activated solution Ecasol as a versatile disinfectant
(Trinity College (Dublin, Ireland). School of Dental Science, 2016)A reservoir of infection is any site in which viable infectious agents can live and grow. Healthcare associated infections (HCAIs) are caused by the acquisition of infectious agents by patients during the course of their ... -
Oral leukoplakia - an investigation of its microbiome and of the association of clinical and microbial features with the degree of dysplasia
Background: With growing evidence of a shift in the oral microbiome associated with oral squamous cell carcinoma, it was hypothesised that the microbiome of oral leukoplakia (OLK), the most common of the 11 recognised oral ... -
Aspects of Dose Optimisation and Diagnostic Efficacy Relating to Dental Cone Beam Computed Tomography (CBCT)
The increasing acceptance of CBCT as a standard form of dental diagnostic imaging is based upon its ability to produce multiplanar cross-sectional (3D) images at a level of resolution that, while not as high as conventional ... -
Functional analysis of the TLO gene family in Candida albicans and Candida dubliniensis
(Trinity College (Dublin, Ireland). School of Dental Science, 2015) -
Molecular epidemiological typing of emerging methicillin-resistant Staphylococcus aureus strains in the community, among livestock and in healthcare facilities in Ireland, 2001-2015
(Trinity College (Dublin, Ireland). Dublin Dental University Hospital. Division of Oral Biosciences, 2017)Methicillin-resistant Staphylococcus aureus (MRSA) has been endemic in Irish hospitals for four decades and displacement of predominant clones has occurred several times. Sequence type (ST) 22 carrying staphylococcal ... -
The role of hyphae and hypha-associated genes in the pathogenesis of Candida dubliniensis
(Trinity College (Dublin, Ireland). School of Dental Science, 2014)Candida albicans is a major cause of superficial and systemic fungal infections in humans. In contrast, its most closely related phylogenetic neighbour, Candida dubliniensis, causes disease much less frequently, despite ... -
A comparison of various methods of assessing salivary flow in normal and xerostomic subjects
(Trinity College (Dublin, Ireland). School of Dental Science, 2006)Saliva is produced by the three major paired salivary glands and minor salivary glands. Alterations in the quantity and quality of saliva have adverse effects on the oral cavity and influence patient quality of Hfe. How ... -
Comparative analysis of stress responses in C. albicans and C. dubliniensis
(Trinity College (Dublin, Ireland). School of Dental Science, 2006)Candida dubliniensis is apathogenic yeast that was first identified as a novel species in 1995. It is phylogenetically very closely related to C. albicans. However, despite the close relationship between the two species, ... -
Comparative growth analysis of Candida dubliniensis and Candida albicans in vitro and in selected infection models
(Trinity College (Dublin, Ireland). School of Dental Science, 2006)Candida dubliniensis is the species most closely related to C. albicans and is primarily associated with colonisation and oral candidiasis in Human Immunodeficiency Virus (HlV)-infected individuals and AIDS patients. Despite ... -
Comparative genetic analysis of nosocomial methicillin-resistant Staphylococcus aureus populations in Ireland 1971-2004
(Trinity College (Dublin, Ireland). School of Dental Science, 2005)Methicillin-resistant Staphylococcus aureus (MRSA) is the most prevalent pathogen responsible for nosocomial infections worldwide and Ireland has one of the highest rates of nosocomial MRSA infections in Europe. In the ... -
Development of long-term practical solutions to the universal problem of biofilm contamination of dental unit waterlines
(Trinity College (Dublin, Ireland). School of Dental Science, 2009)Microbial contamination of dental chair unit (DCU) output water by biofilm growth in dental unit waterlines (DUWLs) is a universal problem and a potentially significant source of cross-infection. At the outset of this ... -
Comprehensive molecular characterisation of endemic and sporadic methicillin resistant Staphylococcus aureus recovered in Irish hospitals
(Trinity College (Dublin, Ireland). School of Dental Science, 2011)Methicillin-resistant Staphylococcus aureus (MRSA) is a prevalent pathogen responsible for hospital- and community-acquired infections worldwide. Molecular typing of Irish MRSA isolates has revealed that different MRSA ... -
An investigation into the relative adhesion of Candida dubliniensis and Candida albicans to human cells and extracellular matrix proteins
(Trinity College (Dublin, Ireland). School of Dental Science, 2009)Candida dubliniensis is a germ tube-positive, chlamydospore-producing yeast species originally recovered from the oral cavities of HIV-infected individuals and AIDS patients and first described in 1995. It is closely related ... -
A population structure analysis of Candida dubliniensis using multilocus sequence typing and an investigation of the molecular mechanism(s) of clade-specific resistance to 5-fluorocytosine
(Trinity College (Dublin, Ireland). School of Dental Science, 2009)Candida dubliniensis shares many phenotypic and genetic characteristics with its closest relative, Candida albicans, which most likely delayed the identification and subsequent classification of C. dubliniensis as a distinct ... -
Biocompatibility of non-precious dental casting alloys : development of novel testing mechanisms
(Trinity College (Dublin, Ireland). School of Dental Science, 2011)The aim of the present investigation was to investigate the biocompatibility potential of commercially available non-precious dental casting alloys facilitated by multiple analyses using a two-dimensional (2D) oral ... -
The strengthening of resin cemented dental ceramic materials
(Trinity College (Dublin, Ireland). School of Dental Science, 2013)The aim of the current investigation was to advance the understanding of the mechanism of resin-strengthening conferred to dental ceramic materials by resin-based composite materials. The investigation is presented as a ... -
The telomere-associated (TLO) genes of Candida dubliniensis
(Trinity College (Dublin, Ireland). School of Dental Science, 2014)Candida species are members of the Saccharomycetuceae and are the most common cause of fungal infections in humans. Diseases caused by these yeasts range from superficial infections (e.g. oropharyngeal & vulvovaginal ... -
Effects of montmorillonite clay addition on the compressive fracture strength and wear resistance of glass-ionomer restoratives
(Trinity College (Dublin, Ireland). School of Dental Science, 2010)The aim of the present investigation was to investigate the influence of montmorillonite (MMT) clay, both as-found (un-modified calcium montmorillonite (Ca-MMT)) and pre-treated to encourage exfoliation (organically-modified ... -
Molecular typing of Methicillin-resistant and Methicillin-susceptible Staphylococcus aureus and Coagulase-negative staphylococci recovered in Irish hospitals and characterisation of SCCmec and SCCmec-containing composite islands
(Trinity College (Dublin, Ireland). School of Dental Science, 2014)Methicillin-resistant Staphylococcus aureus (MRSA) are a major cause of infections in animals and humans. The methicillin resistance gene mecA is located on a mobile genetic element termed the staphylococcal cassette ...