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Targeting the prostate cancer metabolome with novel trojan horse compounds.
(Trinity College Dublin. School of Medicine. Discipline of Histopathology, 2023)
Prostate cancer (PCa) is the second most common cancer diagnosed in males
worldwide, and the incidence of this disease is predicted to double globally by 2030. In Ireland, PCa accounts for nearly 16% of all invasive cancers ...
Corpus of Works submitted for Doctor of Science (Sc.D.)
(Trinity College Dublin. School of Medicine. Discipline of Histopathology, 2023)
HPV Primary Screening Pilot Study: molecular testing of potential triage strategies for HPV-positive women.
(Trinity College Dublin. School of Medicine. Discipline of Histopathology, 2020)
Cytological based screening programmes are being phased out in favour of HPV-based screening both in Ireland and internationally. Infection with HPV is the primary aetiological agent in the development of cervical cancer. ...
Platelet-cancer Cell Interactions induce PAI-1 Expression in an Ovarian Cancer Cell Line Model: Implications for the Metastasis of Epithelial Ovarian Cancer
(Trinity College Dublin. School of Medicine. Discipline of Histopathology, 2021)
This thesis encompasses an investigation into the function of plasminogen activator inhibitor 1 (PAI-1) - a serine protease inhibitor integral to coagulation and fibrinolysis that has been identified as both a key factor ...
Novel 'Test of Disease' Markers in Cervical Pre-cancer
(Trinity College Dublin. School of Medicine. Discipline of Histopathology, 2025)
Background: Cervical cancer screening, diagnostics, and prevention are rapidly changing with the introduction of HPV-based screening and HPV vaccination. This thesis aims to address some of the key challenges with (a) HPV ...