Browsing Histopathology & Morbid Anatomy (Theses and Dissertations) by Title
Now showing items 2-21 of 44
-
C-ABL in human cancer: an investigation of its role in apoptosis inhibition, differentiation and angiogenesis
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2003)Research over the past number of decades has significantly advanced our understanding of the cell signalling effects that mediate a diverse array of cellular activities including cell proliferation, homeostasis and ... -
Cancer cell-platelet interactions in ovarian cancer metastasis
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2012)Ovarian cancer is the leading cause of death from gynaecological malignancy worldwide with an estimated global incidence of 225,900 and mortality of 140,200 per year. In Ireland ovarian cancer is the second most common ... -
Cancer stemness : unravelling the molecular mechanisms controlling stem cell differentiation and self-renewal
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2009)Understanding the molecular mechanisms behind cancer cell proliferation and regulation is the key to discovering potential future successful therapies for cancer. The World Health Organisation estimates that 7.6 million ... -
Corpus of Works submitted for Doctor of Science (Sc.D.)
(Trinity College Dublin. School of Medicine. Discipline of Histopathology, 2023) -
Developing novel therapeutic approaches in chemoresistant ovarian cancer patients
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2012)Ovarian cancer is the fifth most common cause of cancer death in women and is the leading cause of death from gynaecological malignancy in the Western world. A recent study by the National Cancer Registry, Ireland has shown ... -
Development of extraction and analysis of protocols for RNA in formalin-fixed paraffin-embedded (FFPE) materials using TaqMan® real-time PCR
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2009)Archival Formalin-Fixed, Paraffin-Embedded (FFPE) tissue samples represent an invaluable source of human tissue for gene expression analysis. They are the most abundant and readily available materials and generally well ... -
Diagnostic and prognostic biomarkers in ovarian cancer
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2013)Ovarian cancer is the fifth most common cancer in women and the most frequent cause of gynaecological malignancy-related mortality in women. The vast majority present in advanced stages and this is due to lack of a reliable ... -
Differential expression of differentation, key stemness and pathways genes and microRNAs and the role of Tgf-β in embryonal carinoma stem cells
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2010)Cancer stem cells (CSCs) identified in multiple malignancies has fuelled the belief that they drive primary tumourigenesis. Their persistence post-intervention contributes to metastasis, recurrence, self-renewal, thus ... -
ECHO: the epidemiology of HPV infection in oropharyngeal, oral cavity, and laryngeal cancer in Ireland
(Trinity College Dublin. School of Medicine. Discipline of Histopathology, 2019)Human Papillomavirus (HPV) infection has been identified as a significant etiological agent in the development of head and neck squamous cell carcinoma (HNSCC). There is mounting evidence from North America and Europe to ... -
Genome wide investigation of papillary thyroid carcinoma
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2005)In recent years, there has been a technological explosion in the fields of molecular pathology and molecular oncology. The genome, transcriptome and increasingly the proteome of diverse tumours can now be analysed in minute ... -
HPV mRNA and p16[ink4a] / Ki-67 detection for improved diagnosis and management of cervical neoplasia in smokers
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2012)Persistent infection with high risk human papillomavirus (HR HPV) is the main etiological agent in the development of cervical cancer. The use of HPV DNA testing in cervical screening programs is becoming increasingly ... -
HPV Primary Screening Pilot Study: molecular testing of potential triage strategies for HPV-positive women.
(Trinity College Dublin. School of Medicine. Discipline of Histopathology, 2020)Cytological based screening programmes are being phased out in favour of HPV-based screening both in Ireland and internationally. Infection with HPV is the primary aetiological agent in the development of cervical cancer. ... -
Human papillomavirus prevalence in the Irish cervical screening population and a specific group of HIV positive women
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2011)Human Papillomavirus (HPV) is the major aetiological agent in the development of cervical pre-cancer and cancer with high-risk HPV (HR-HPV) types 16 and 18 detected in greater than 70% of squamous cell carcinomas of the ... -
Identification of novel biomarkers in recurrent / chemoresistant ovarian cancer
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2009)The aim of this study was to identify novel biomarkers in recurrent/chemoresistant ovarian cancer, yet an incurable disease. Using cDNA microarrays, we identified distinct patterns of gene expression between primary and ... -
Identification, isolation and validation of ovarian cancer stem cells
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2013)Ovarian cancer is often diagnosed at a late stage. Even so, it often responds (~73 %) to first-line therapies. However, the five year survival rate for late stage ovarian cancer is poor (~27 %). It is hypothesised that ... -
Investigation of autoantibody profiling to reveal biomarkers of ovarian cancer
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2013)Ovarian cancer is the most deadly gynaecological malignancy and 70% of all women with ovarian cancer die within 5 years of diagnosis. When diagnosed in early stages, ovarian cancer is curable in 90% of cases, however early ... -
Investigation of oral and oropharyngeal squamous cell carcinoma in young adults
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2006)While oral and pharyngeal squamous cell carcinoma is classically a disease of older male smokers, this tumour type can occur in young patients with minimal or no exposure to the traditional risk factors. The prognosis ... -
MicroRNA profiling in prostate cancer and prostate derived holoclone cell model
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2012)Prostate cancer is a heterogeneous disease and is the most commonly diagnosed malignant tumour and the second most common cause of cancer deaths in western males. Prostate cancer is the most commonly diagnosed cancer in ... -
Molecular algorithms in ovarian serous neoplasia
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2009)Epithelial ovarian cancer is one of the most common cancers in women and the leading cause of death from gynaecological malignancy in the western world. Approximately 205,000 cases of ovarian cancer are diagnosed worldwide ... -
Molecular algorithms in thyroid neoplasia
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2005)Papillary thyroid carcinoma is the most comm on thyroid malignancy, with an incidence of <100 cases per year in Ireland and 16,000 cases per year in the U.S. Incidence is increasing with a global estimate of half a million ...
