RSS 1.0Medical Gerontology (Theses and Dissertations)
Recent Submissions
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Cerebral haemodynamics in older adults: Multi-modal studies utilizing near infrared spectroscopy and non-invasive continuous blood pressure monitoring in a large longitudinal cohort
(Trinity College Dublin. School of Medicine. Discipline of Medical Gerontology, School of Medicine, Trinity College Dublin, 2025)Sufficient cerebral blood flow (CBF) is critical for brain health and normal cognitive function, and cerebral hypoperfusion is implicated as a pathway to cognitive decline, as well as other adverse outcomes such as falls, ... -
Orthostatic Hypotension and Cerebral Perfusion in Falls and Related Syncopal Disorders
(Trinity College Dublin. School of Medicine. Discipline of Medical Gerontology, 2025)Falls, syncope and orthostatic dizziness are common reasons for hospital presentations and are highly prevalent among older adults, leading to significant morbidity, loss of independence and increased healthcare utilisation. ... -
Sarcopenia and Orthostatic Hypotension: Investigating the Underlying Haemodynamics
(Trinity College Dublin. School of Medicine. Discipline of Medical Gerontology, 2025)The ageing population worldwide is both one of the greatest successes of modern humanity and one of its greatest challenges. These challenges are numerous and include the geriatric syndromes of sarcopenia and orthostatic ... -
Folate and Vitamin B12 in The Irish Longitudinal Study on Ageing cohort: associations with cognitive function
(Trinity College Dublin. School of Medicine. Discipline of Medical Gerontology, 2024)The aim of this Ph.D. thesis is to examine nutrition, cognitive and autonomic dysfunction in the older population in Ireland. One review and five separate quantitative studies are presented in this thesis, which use data ... -
VINCI-AD: Investigating Transcutaneous Vagus Nerve Stimulation in Amnestic Mild Cognitive Impairment
(Trinity College Dublin. School of Medicine. Discipline of Medical Gerontology, 2025)Abstract Introduction New treatments are urgently needed for individuals with Mild Cognitive Impairment (MCI) - in particular for those with amnestic MCI as they are at highest risk for developing dementia. Transcutaneous ... -
Metabolic Syndrome and Accelerated Biological Ageing
Introduction: Metabolic syndrome consists of the cluster of obesity, insulin resistance, hypertension, and atherogenic dyslipidaemia. This syndrome is a risk factor for all-cause mortality but has not been well characterised ... -
An evaluation ofthe Allostatic Load framework for quantifying differences inhealth and longevity
(Trinity College Dublin. School of Medicine. Discipline of Medical Gerontology, 2023)The Allostatic Load (AL) framework posits that chronic or repeated exposure to stressors can cause dysregulation of multiple interrelated physiological systems, which if prolonged, may ultimately lead to deteriorations in ... -
Identification of predictors of gait speeds in The Irish Longitudinal Study on Ageing using automated feature selection and explainable machine learning
(Trinity College Dublin. School of Medicine. Discipline of Medical Gerontology, 2023)This work reports the novel application of automated feature selection and explainable machine learning to identify and compare, in participants aged 50 years or over from wave 3 of The Irish Longitudinal Study on Ageing ... -
The Age-Old Question of ANCA-Associated Vasculitis
(Trinity College Dublin. School of Medicine. Medical Gerontology, 2023)Anti-Neutrophil Cytoplasmic Autoantibody (ANCA)-Associated Vasculitis (AAV) is a group of systemic autoimmune disorders characterised by severe inflammation of the small blood vessels. Unusually for an autoimmune disease, ... -
Clinical Decision Support for the Assessment of Syncope and Falls: Novel Applications of Cerebral Perfusion Measurement and Big Data Analytics
(Trinity College Dublin. School of Medicine. CentreFor Medical Gerontology, 2023)Syncope, defined as a transient loss of consciousness due to cerebral hypoperfusion, is common in both young and old, with syncope an attributable cause of unexplained falls (UF) in older adults. Both syncope and falls ... -
Determinants of Physical Activity Engagement and Physical Activity Intervention Adherence in Individuals with Mild Cognitive Impairment: A Mixed Methods Study
(Trinity College Dublin. School of Medicine. CentreFor Medical Gerontology, 2022)The overarching aim of this thesis was to to identify the determinants of PA engagement and PA intervention adherence in individuals with MCI to expand on this under-researched topic and better inform PA promotion and ... -
Sleep habits in older adults in Ireland: Associations with physical and cognitive function
(Trinity College Dublin. School of Medicine. CentreFor Medical Gerontology, 2021)Sleep acts as the rest cycle for the body, during which restorative processes such as muscle growth, repair and memory consolidation occur. Sleep duration and chronotype have been identified as areas of interest to improve ... -
Exploring Novel Biomarkers of Brain Health in Midlife Type 2 Diabetes Mellitus (ENBIND)
(Trinity College Dublin. School of Medicine. CentreFor Medical Gerontology, 2020)Type 2 Diabetes Mellitus (T2DM) in midlife (between the ages of 35-65) is associated with a two-fold increased risk of dementia in later life. Despite this, knowledge around the pathophysiological mechanisms linking T2DM ... -
Ageing outcomes in women and men in Ireland: the role of the religious social context
(Trinity College Dublin. School of Medicine. CentreFor Medical Gerontology, 2020)Aim & background: The aim of this thesis is to explore how the religious social context in Ireland has helped shape the health and ageing outcomes of older women and men. Understanding the factors behind the ability to ... -
The Association between Blood Pressure, Cerebral Perfusion and Late Life Depression
(Trinity College Dublin. School of Medicine. CentreFor Medical Gerontology, 2020)Background: While late life is generally characterised by contentment and happiness, depression in later life confers an independently increased risk of early mortality, cognitive and functional decline and nursing home ... -
Cardiovascular Autonomic Nervous System, Blood Pressure Instability and Brain Health in Older Adults: Population-Based Perspectives
(Trinity College Dublin. School of Medicine. CentreFor Medical Gerontology, 2019)The aim of this thesis is to provide new insights into the shared pathways by which the cardiovascular autonomic nervous system underpins optimal regulation of affect and cognitive function in older adults. Ageing is ... -
The Effects of Acute and Chronic Exercise on Brain Derived Neurotrophic Factor and Cognitive Performance in Mild Cognitive Impairment
(Trinity College Dublin. School of Medicine. CentreFor Medical Gerontology, 2019)Introduction: Brain Derived Neurotrophic Factor (BDNF) is a neurotrophin that supports neural survival, growth and synaptic plasticity and is upregulated through exercise. While the exact neuronal mechanisms underlying the ... -
Impact of assistance on the quality of life of older adults with activities of daily living & instrumental activities of daily living disabilities
(Trinity College Dublin. School of Medicine. CentreFor Medical Gerontology, 2018)As populations age, incidence of functional limitation including disability in Activities of Daily Living and Instrumental Activities of Daily Living increases. This creates a higher level of demand for technological and ... -
Cardiovascular associations of falls and syncope in the elderly
(Trinity College Dublin. School of Medicine. CentreFor Medical Gerontology, 2017)The principle aims of this doctoral investigation are to provide new insights into the relationship between cardiovascular disease (CVD) and falls in the elderly population in Ireland. The rapidly ageing global demographic ... -
Treatment of osteoporosis with recombinant parathyroid hormone, its effects on bone, total body muscle and fat composition and factors determining response to this therapy
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Medical Gerontology, 2015)Total body bone mineral density (BMD) is relatively underutilised as an assessment tool for osteoporosis. Studies to date on Body composition have not clearly identified key factors which contribute to total body BMD, ...
