Browsing Psychiatry (Scholarly Publications) by Sponsor "Medical Research Council"
Now showing items 1-7 of 7
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ALS2/Alsin regulates Rac-PAK signaling and neurite outgrowth.
(American Society for Biochemistry and Molecular Biology, 2005)Rac and its downstream effectors p21-activated kinase (PAK) family kinases regulate actin dynamics within growth cones to control neurite outgrowth during development. The activity of Rac is stimulated by guanine ... -
Dissociation in performance of children with ADHD and high-functioning autism on a task of sustained attention.
(Elsevier, 2007)Attention deficit hyperactivity disorder (ADHD) and autism are two neurodevelopmental disorders associated with prominent executive dysfunction, which may be underpinned by disruption within fronto-striatal and fronto-parietal ... -
Gene-environment interplay in attention-deficit hyperactivity disorder and the importance of a develomental perspective
(The Royal College of Psychiatrists, 2007)Attention-deficit hyperactivity disorder (ADHD) varies in its clinical presentation and course. Susceptibility gene variants for ADHD and associated antisocial behaviour are being identified with emerging evidence of ... -
Identification of a novel, membrane-associated neuronal kinase, cyclin-dependent kinase 5/p35-regulated kinase.
(The Society for Neuroscience, 2003)Here we characterize a novel neuronal kinase, cyclin-dependent kinase 5 (cdk5)/p35-regulated kinase (cprk). Cprk is a member of a previously undescribed family of kinases that are predicted to contain two N-terminal ... -
X11beta rescues memory and long-term potentiation deficits in Alzheimer's disease APPswe Tg2576 mice.
(2009)Increased production and deposition of amyloid ?-protein (A?) are believed to be key pathogenic events in Alzheimer?s disease. As such, routes for lowering cerebral A? levels represent potential therapeutic targets for ...
