Browsing Psychiatry (Scholarly Publications) by Sponsor "European Union (EU)"
Now showing items 1-8 of 8
-
The c-Abl tyrosine kinase phosphorylates the Fe65 adaptor protein to stimulate Fe65/amyloid precursor protein nuclear signaling.
(American Society for Biochemistry and Molecular Biology, 2004)The amyloid precursor protein (APP) is proteolytically processed to release a C-terminal domain that signals to the nucleus to regulate transcription of responsive genes. The APP C terminus binds to a number of phosphotyrosine ... -
Familial amyotrophic lateral sclerosis-linked SOD1 mutants perturb fast axonal transport to reduce axonal mitochondria content.
(Oxford University Press, 2007)Amyotrophic lateral sclerosis (ALS) is a late-onset neurological disorder characterized by death of motoneurons. Mutations in Cu/Zn superoxide dismutase-1 (SOD1) cause familial ALS but the mechanisms whereby they induce ... -
A frailty instrument for primary care: findings from the Survey of Health, Ageing and Retirement in Europe (SHARE).
(2010)Background: A frailty paradigm would be useful in primary care to identify older people at risk, but appropriate metrics at that level are lacking. We created and validated a simple instrument for frailty screening in ... -
Genes predict village of origin in rural Europe.
(2010)The genetic structure of human populations is important in population genetics, forensics and medicine. Using genome-wide scans and individuals with all four grandparents born in the same settlement, we here demonstrate ... -
Recurrent Rearrangements of Chromosome 1q21.1 and Variable Pediatric Phenotypes
(Massachusetts Medical Society, 2008)Background Duplications and deletions in the human genome can cause disease or predispose persons to disease. Advances in technologies to detect these changes allow for the routine identification of submicroscopic imbalances ...
