Now showing items 1-20 of 74

    • Mental disorders in the community dwelling elderly 

      Kirby, Michael (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2000)
      The elderly population is increasing both in numbers and as a proportion of the overall population. Mental disorders are common among the elderly. Most older people with mental disorders live in the community and attend ...
    • Mental health in Northern Malawi : a cultural perspective 

      Smyth, Karen M. (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2002)
      This thesis seeks to address a theoretical question: What is the experience of people with a mental disturbance, when they are introduced to a health care system which is ontologically distinct from their own cultural ...
    • Caring for a child with an autistic spectrum disorder over the life span 

      Coulthard, Patricia (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2003)
      Carers of children on the autistic spectrum have stressful lives (Randall & Parker, 1999). The aim of this study was to investigate the life of the carer, and in particular to examine how they have coped, their support ...
    • The influence of Alzheimer's dementia on time spent caregiving for persons with Down Syndrome 

      McCarron, Mary (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2003)
      Background: Persons with Down syndrome (DS) are at increased risk of Alzheimer’s type dementia (AD) when compared to the general population, yet little attention has been paid to the impact of the illness on such persons ...
    • Molecular genetics investigations in autism 

      Gallagher, Louise (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2004)
      This research thesis involved the establishment and management of a research group in autism genetics in addition to the collection of an autism sample of parent-child trios. A well-characterised sample of individuals with ...
    • Methodological issues in event-related fMRI 

      Murphy, Kevin (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2005)
      Functional magnetic resonance imaging (fMRI) is a very powerful tool for localising psychological functions to specific brain areas. Recently, there has been a surge of interest in determining the functional differences ...
    • A candidate gene search for autism 

      Conroy, Judith (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2006)
      This research involved a candidate gene search for autism in the Irish population. It sought to identify candidate genes based on information from linkage studies, reports of chromosomal abnormalities, animal studies and ...
    • A molecular genetic investigation of schizophrenia in an Irish study population 

      Corvin, Aiden (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2006)
      Schizophrenia (OMIM 181500) is a complex genetic disorder, which affects ~1% of the population, and typically presents in early adulthood with abnormalities of perception (psychosis), cognition, information processing and ...
    • Bereavement and people with intellectual disabilities 

      Dodd, Philip Charles (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2007)
      For most people, the loss of a loved one is a tragedy unequalled by any other. It affects every family and raises policy and logistic issues for the health and social service agencies of every community. Currently, people ...
    • Characterising schizophrenia candidate susceptibility genes using intermediate phenotypes 

      Donohoe, Gary (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2008)
      This thesis describes the use of intermediate phenotypes as a method for understanding, at a behavioural level, the functional significance of candidate susceptibility genes for schizophrenia. The historical context for ...
    • Subsyndromal depression and anxiety predictors, consequences and two year outcome in the Irish elderly 

      Greene, Elaine (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2008)
      Depression is the commonest mental illness in late life and frequently occurs co- morbidly with anxiety. While all levels of illness severity have been reported a significant proportion of older adults suffer with clinically ...
    • Investigation of putative candidate genes involved in the pathogenesis of Schizophrenia using a large Irish case-control sample 

      McGhee, Kevin (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2008)
      This research thesis involved a candidate gene search for schizophrenia in the Irish population. It sought to identify candidate genes based on positional and functional information contained in previously published material. ...
    • The contributions of knowledge and contact to the stigma of mental illness 

      Byrne, Peter (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2008)
      Study One is a single face-to-face questionnaire study of 243 patients with psoriasis and/or arthritis. Because leprosy is an infectious condition, psoriasis is a better model of a stigmatising skin disorder likely to cause ...
    • Family-based association and molecular genetic analysis of genes implicated in the aetiology of autism 

      Cochrane, Lynne (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2009)
      Autism is an early onset neurodevelopmental disorder affecting three core areas of behaviour - communication, social behaviour and restricted/repetitive behaviour. Although family and twin studies indicate a genetic ...
    • The effect of catecholaminergic genes on executive functions : a behavioural and fMRI study 

      Greene, Ciara Mary (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2009)
      This thesis describes a study in two parts aimed at elucidating genetic links to executive functions and their neurological correlates. The catecholamines (in particular dopamine and noradrenaline) are known to be heavily ...
    • Symptoms of autism in ADHD : a familial trait in a subset of children with ADHD which correlates with comorbid oppositional defiant disorder, conduct disorder and motor disorder 

      Mulligan, Aisling (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2009)
      Introduction; This study examines autism symptoms in a sample of children with ADHD, in their siblings, and in a control sample. Study sample: 821 children with ADHD, combined type who were participating in the International ...
    • Interferon-alpha-induced cognitive and affective impairments : contributions of prefrontal cortex and hippocampal formation 

      Barlow, Sally (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2009)
      Interferon-alpha (IFN-a) is a potent antiviral agent useful in the treatment of many malignancies, but most widely used in the treatment of Hepatitis C. However, sinister adverse events appear as a consequence of ...
    • Neurocognitive changes in associative- and working memory with aging 

      Feeney, Joanne (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2010)
      This thesis sought to determine the nature of associative- and working memory dechne during adulthood, and to try and elucidate some of the factors which contribute to this age- related mnemonic decline. In the first study ...
    • Phenotypic and molecular genetic analysis of autism 

      Tansey, Katherine (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2010)
      Autism is an early onset neurodevelopmental disorder affecting three core areas of behaviour - communication, social interaction and restricted repetitive behaviour. Although family and twin studies indicate a genetic ...
    • Investigation of glutamatergic synapse genes in schizophrenia susceptibility : from linkage to genome-wide association studies 

      Gilks, William (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2011)
      Schizophrenia is a common and severe mental illness which is highly heritable. Susceptibility to schizophrenia is likely to be caused by multiple genetic variants in combination with environmental risk factors. The ...