Browsing Psychiatry (Theses and Dissertations) by Title
Now showing items 48-67 of 74
-
Mental Capacity for Treatment Decisions in Psychiatry Inpatients
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2024)This research aimed to assess the prevalence of mental capacity for treatment decisions in psychiatry inpatients in Ireland and elucidate the relationship, if any, between mental capacity and key clinical and demographic ... -
Mental disorders in the community dwelling elderly
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2000)The elderly population is increasing both in numbers and as a proportion of the overall population. Mental disorders are common among the elderly. Most older people with mental disorders live in the community and attend ... -
Mental health in Northern Malawi : a cultural perspective
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2002)This thesis seeks to address a theoretical question: What is the experience of people with a mental disturbance, when they are introduced to a health care system which is ontologically distinct from their own cultural ... -
Methodological issues in event-related fMRI
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2005)Functional magnetic resonance imaging (fMRI) is a very powerful tool for localising psychological functions to specific brain areas. Recently, there has been a surge of interest in determining the functional differences ... -
The molecular determinant of IGF-1(Mecasermin)action in Rett Syndrome Patients
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2018)Abstract This is a preliminary investigation of effects of insulin-like growth factor-1 (IGF-1) treatment on differential gene expression (DGE) of whole blood samples from Rett syndrome (RTT) patients. Samples were ... -
Molecular genetics investigations in autism
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2004)This research thesis involved the establishment and management of a research group in autism genetics in addition to the collection of an autism sample of parent-child trios. A well-characterised sample of individuals with ... -
The Molecular Mechanisms of rhIGF1 in the Treatment of Rett Syndrome and Related Disorders: Studies in Patients, Mouse and Cellular Models
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2022)Recombinant human Insulin-like Growth Factor 1 (rhIGF1) is an approved treatment for growth failure and IGF1 deficiency. IGF1 has multiple functions in the body including growth, cell survival, metabolism, ageing and ... -
Molecular pathways of depression and antidepressant therapies for treatment resistant depression
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2020)According to the World Health Organisation, depression is the most common psychiatric disorder. Despite this, the pathophysiology of depression is unclear. Electroconvulsive therapy (ECT) is the most acutely effective ... -
Multimodal Approach to Endophenotype Discovery in Disorders with Genetic Liability
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2019)Neurodevelopmental and Neurodegenerative disorders constitute a huge weight on society in terms of human suffering and economic cost. In recent years an increasing amount of emphasis has been placed on investigating the ... -
Neurocognitive changes in associative- and working memory with aging
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2010)This thesis sought to determine the nature of associative- and working memory dechne during adulthood, and to try and elucidate some of the factors which contribute to this age- related mnemonic decline. In the first study ... -
Neuroimaging to Assess Neonatal Brain Development and Brain Injury in Neonatal Encephalopathy
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2023)Neonatal encephalopathy (NE) is a clinical syndrome describing perinatal brain injury and neurological dysfunction in the term-born infant. Magnetic resonance imaging (MRI) is a widely used tool in the assessment of NE, ... -
Neuropsychosocial predictors of outcomes in opioid dependent patients post-detoxification
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2015)The current treatment of choice for most opiate dependent persons is long term substitute prescribing. Detoxification is not an effective stand-alone treatment. Given the weak evidence base for detoxification coupled with ... -
Perinatal Depression and Children's Developmental Outcomes at 2 and 3 Years Postpartum
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2022)Depression is the most common perinatal psychiatric disorder and has been associated with a range of adverse outcomes for children, parents and overall family functioning. The current thesis sought to build on existing ... -
Phenotypic and molecular genetic analysis of autism
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2010)Autism is an early onset neurodevelopmental disorder affecting three core areas of behaviour - communication, social interaction and restricted repetitive behaviour. Although family and twin studies indicate a genetic ... -
The role of FKBP5 genetics and epigenetics in mediating the effects of early life adversity on emotional processing brain regions in major depressive disorder
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2018)Major depressive disorder (MDD) is the most widespread psychiatric illness and is characterized by loss of pleasure, depressed mood, sleep disturbances and anxiety. Recently, an inflammatory theory of MDD has emerged, which ... -
Social cognition in borderline personality disorder : an MRI investigation
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2013)There is increasing evidence for subtle changes in brain morphology and function in patients with borderline personality disorder (BPD). The four study arms in this thesis seek to investigate the differences in personality, ... -
Structural Changes of Brain Areas Involved in Emotion and Memory Processing across Lifespan
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2020)People are defined by their genes, familiar background and personal experiences, that can have either a negative or positive impact. Altogether, this represents and shapes their decisions, behaviours and relationships with ... -
Subsyndromal depression and anxiety predictors, consequences and two year outcome in the Irish elderly
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2008)Depression is the commonest mental illness in late life and frequently occurs co- morbidly with anxiety. While all levels of illness severity have been reported a significant proportion of older adults suffer with clinically ... -
Symptoms of autism in ADHD : a familial trait in a subset of children with ADHD which correlates with comorbid oppositional defiant disorder, conduct disorder and motor disorder
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2009)Introduction; This study examines autism symptoms in a sample of children with ADHD, in their siblings, and in a control sample. Study sample: 821 children with ADHD, combined type who were participating in the International ... -
The aging brain : an investigation into cognitive training and resting state networks in healthy older adults
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2013)Investigating the complexities surrounding the aging brain is of vital importance if we are to fully understand the mechanisms of aging. A greater understanding of aging may perhaps pave the way for new ideas and innovations ...
