Browsing Psychiatry (Theses and Dissertations) by Title
Now showing items 31-50 of 74
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Implications of cortical structure and connectivity in autism spectrum disorder
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2015)Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterised by early-onset deficits in social communication and interaction together with recurrent restricted repetitive behaviours (APA, 2013). Insights ... -
The importance of cognitive deficits for forensic mental health patients with schizophrenia or schizoaffective disorder
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2020)Forensic Mental Health Services (FMHS) provide care and treatment to a minority of people with mental illness like schizophrenia or schizoaffective disorder, who come into contact with law enforcement agencies (Kennedy et ... -
India's Mental Healthcare Act, 2017 Evaluation of the Act, its Context and Initial Implementation
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2022)The United Nations has initiated a paradigmatic shift in mental healthcare through the United Nations Convention on the Rights of Persons with Disabilities (CRPD), in addition to this the WHO has identified legislation as ... -
Inflammatory markers of antipsychotic weight gain and cardiometabolic dysfunction in youth mental health disorders
Second generation antipsychotics (SGAs) are used in children and adolescents to treat psychotic symptoms in Early Onset Psychosis (EOP) and irritability and behaviours that challenge in autism spectrum disorder (ASD). ... -
Interferon-alpha-induced cognitive and affective impairments : contributions of prefrontal cortex and hippocampal formation
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2009)Interferon-alpha (IFN-a) is a potent antiviral agent useful in the treatment of many malignancies, but most widely used in the treatment of Hepatitis C. However, sinister adverse events appear as a consequence of ... -
Investigating clinically relevant phenotypes of neurodevelopmental copy number variants in Children and Adults
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2021)Background: Neurodevelopmental copy number variants (ND CNVs) present with clinically pleiotropic effects, transcending psychiatric diagnostic borders. Gaining clarity on the neurodevelopmental and psychiatric phenotypic ... -
Investigating risk factors and clinical correlates of copy number variants in Autism Spectrum Disorders and schizophrenia
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2013)Autism Spectrum Disorders (ASD) (OMIM 209850) and schizophrenia (OMIM 181510) are both complex neurodevelopmental disorders with extensive emotional and physical costs. Although there has been some progress in understanding ... -
Investigating the effects of schizophrenia genome-wide associated variants on white matter microstructure and brain morphology using diffusion tenson imaging and quantitative MRI
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2014)This thesis describes four studies that aim to to elucidate the effects of schizophrenia genome-wide associated variants on measures of white matter microstructure, cortical thickness, surface area and subcortical volume. ... -
Investigation of glutamatergic synapse genes in schizophrenia susceptibility : from linkage to genome-wide association studies
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2011)Schizophrenia is a common and severe mental illness which is highly heritable. Susceptibility to schizophrenia is likely to be caused by multiple genetic variants in combination with environmental risk factors. The ... -
Investigation of putative candidate genes involved in the pathogenesis of Schizophrenia using a large Irish case-control sample
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2008)This research thesis involved a candidate gene search for schizophrenia in the Irish population. It sought to identify candidate genes based on positional and functional information contained in previously published material. ... -
Investigation of rare sequence variants in putative susceptibility genes for schizophrenia and autism spectrum disorders
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2013)Schizophrenia (SZ) and Autism Spectrum Disorders (ASD) are complex neuropsychiatric disorders that have a very large health, societal and economic burden in Ireland. They affect approximately 1% and 0.8% of the population ... -
Investigation of S100B gene as a risk factor for biopolar disorder and schizophrenia
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2012)Calcium-binding protein S100B has been implicated in the pathology of bipolar affective disorder (BPAD) and schizophrenia (SZP). S100B protein levels are elevated in serum of patients with both disorders compared to controls. ... -
An investigation of the effect of maternal depression during pregnancy on maternal and infant hypothalamic-pituitary-adrenal axes
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2018)Background: Pregnancy is a period of increased vulnerability for developing depression. Several maternal physiological systems, including the hypothalamic-pituitary-adrenal (HPA) axis undergo changes during pregnancy. ... -
An investigation of the role of antenatal depression, maternal cortisol and postnatal interactive behaviour on infant neurodevelopment in the first year of life.
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2019)Abstract Aims: Major Depressive Disorder (MDD) is the most prevalent psychiatric disorder during the perinatal period and can lasting adverse effects on maternal wellbeing and infant development. This aim of this thesis ... -
Investigation of α-tubulins as translational biomarkers of major depressive disorder: indications for disease severity and treatment efficacy
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2020)Introduction: Major Depressive Disorder is a significant cause of disability worldwide. In a 2017 report, the World Health Organisation estimated that 320 million people suffered from depression globally. Although several ... -
Limbic System Development in Children and Adolescents with Attention Deficit/Hyperactivity Disorder: A Longitudinal Multimodal MRI Analysis
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2024)While Attention-Deficit Hyperactivity Disorder (ADHD) is characterized by age-related changes in symptoms and brain structures during childhood and adolescence, the link between brain structure and function is less clear. ... -
Long-term outcomes following electroconvulsive therapy for treatment-resistant depression
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2016)Background: Electroconvulsive therapy (ECT) is the most acutely effective treatment for depression but its use is limited by high rates of early relapse and retrograde amnesia of uncertain severity and duration. Aims: ... -
Mental Capacity for Treatment Decisions in Psychiatry Inpatients
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2024)This research aimed to assess the prevalence of mental capacity for treatment decisions in psychiatry inpatients in Ireland and elucidate the relationship, if any, between mental capacity and key clinical and demographic ... -
Mental disorders in the community dwelling elderly
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2000)The elderly population is increasing both in numbers and as a proportion of the overall population. Mental disorders are common among the elderly. Most older people with mental disorders live in the community and attend ... -
Mental health in Northern Malawi : a cultural perspective
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2002)This thesis seeks to address a theoretical question: What is the experience of people with a mental disturbance, when they are introduced to a health care system which is ontologically distinct from their own cultural ...
