Browsing Psychiatry (Theses and Dissertations) by Title
Now showing items 23-42 of 74
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Family-based association and molecular genetic analysis of genes implicated in the aetiology of autism
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2009)Autism is an early onset neurodevelopmental disorder affecting three core areas of behaviour - communication, social behaviour and restricted/repetitive behaviour. Although family and twin studies indicate a genetic ... -
Frailty in an older population : the impact on community-dwelling elders, dementia patients and older caregivers
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2012)Frailty represents one of the greatest gerontological challenges faced by societies in coming years. Growing numbers of older citizens leads not only to increasing numbers of healthy elders, but also frail and disabled elders. -
Fuctional and structural brain changes in ageing related to emotional processing
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2012)Of all mental abilities emotional processing is well-preserved in healthy ageing. In spite of this, the neural substrates of emotional processing in ageing are still not fully understood. In this project several experiments ... -
Functional investigation of neurodevelopmental effects of DISC1 and related psychosis risk genes
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2015)Schizophrenia (SCZ) is a severe neurodevelopmental disorder, which affects about 1% of the population worldwide, and whose symptoms start during early adulthood. SCZ is determined by the interaction of genetic and environmental ... -
Functional neural differences in emotional regualtion between patients with MDD and healthy controls in the context of the vulnerability factors : family history of MDD, BDNF Val66Met polymorphism
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2012)Emotional regulation is a key mechanism which shows disturbances during major depressive disorder (MDD), and which may be modified by certain factors enhancing vulnerability to MDD. Two vulnerability factors were tested ... -
Genetic and molecular studies of rare variation in schizophrenia
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2014)Schizophrenia (SCZ) is a severe and debilitating disorder and it has a worldwide prevalence estimated at approximately 1%. The underlying pathogenesis of SCZ is poorly understood and there is a great need for diagnostic ... -
High dose right unilateral versus moderate dose bilateral ECT for major depression : time to re-orientation, physical functioning, quality of life and attitudes
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2012)The objective of this study was to compare the effects of 1.5 x seizure threshold (ST) bitemporal ECT with high dose (6 x ST) right unilateral (RUL) ECT with respect to immediate recovery from treatment, change in physical ... -
The hippocampus, amygdala and their principal output tracts in major depressive disorder
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2019)Major depressive disorder is a common, debilitating illness. Despite its high prevalence rate and global disease burden, the biological mechanisms underlying this disorder remain largely unknown. Evidence points towards ... -
Implications of cortical structure and connectivity in autism spectrum disorder
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2015)Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterised by early-onset deficits in social communication and interaction together with recurrent restricted repetitive behaviours (APA, 2013). Insights ... -
The importance of cognitive deficits for forensic mental health patients with schizophrenia or schizoaffective disorder
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2020)Forensic Mental Health Services (FMHS) provide care and treatment to a minority of people with mental illness like schizophrenia or schizoaffective disorder, who come into contact with law enforcement agencies (Kennedy et ... -
India's Mental Healthcare Act, 2017 Evaluation of the Act, its Context and Initial Implementation
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2022)The United Nations has initiated a paradigmatic shift in mental healthcare through the United Nations Convention on the Rights of Persons with Disabilities (CRPD), in addition to this the WHO has identified legislation as ... -
Inflammatory markers of antipsychotic weight gain and cardiometabolic dysfunction in youth mental health disorders
Second generation antipsychotics (SGAs) are used in children and adolescents to treat psychotic symptoms in Early Onset Psychosis (EOP) and irritability and behaviours that challenge in autism spectrum disorder (ASD). ... -
Interferon-alpha-induced cognitive and affective impairments : contributions of prefrontal cortex and hippocampal formation
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2009)Interferon-alpha (IFN-a) is a potent antiviral agent useful in the treatment of many malignancies, but most widely used in the treatment of Hepatitis C. However, sinister adverse events appear as a consequence of ... -
Investigating clinically relevant phenotypes of neurodevelopmental copy number variants in Children and Adults
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2021)Background: Neurodevelopmental copy number variants (ND CNVs) present with clinically pleiotropic effects, transcending psychiatric diagnostic borders. Gaining clarity on the neurodevelopmental and psychiatric phenotypic ... -
Investigating risk factors and clinical correlates of copy number variants in Autism Spectrum Disorders and schizophrenia
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2013)Autism Spectrum Disorders (ASD) (OMIM 209850) and schizophrenia (OMIM 181510) are both complex neurodevelopmental disorders with extensive emotional and physical costs. Although there has been some progress in understanding ... -
Investigating the effects of schizophrenia genome-wide associated variants on white matter microstructure and brain morphology using diffusion tenson imaging and quantitative MRI
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2014)This thesis describes four studies that aim to to elucidate the effects of schizophrenia genome-wide associated variants on measures of white matter microstructure, cortical thickness, surface area and subcortical volume. ... -
Investigation of glutamatergic synapse genes in schizophrenia susceptibility : from linkage to genome-wide association studies
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2011)Schizophrenia is a common and severe mental illness which is highly heritable. Susceptibility to schizophrenia is likely to be caused by multiple genetic variants in combination with environmental risk factors. The ... -
Investigation of putative candidate genes involved in the pathogenesis of Schizophrenia using a large Irish case-control sample
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2008)This research thesis involved a candidate gene search for schizophrenia in the Irish population. It sought to identify candidate genes based on positional and functional information contained in previously published material. ... -
Investigation of rare sequence variants in putative susceptibility genes for schizophrenia and autism spectrum disorders
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2013)Schizophrenia (SZ) and Autism Spectrum Disorders (ASD) are complex neuropsychiatric disorders that have a very large health, societal and economic burden in Ireland. They affect approximately 1% and 0.8% of the population ... -
Investigation of S100B gene as a risk factor for biopolar disorder and schizophrenia
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2012)Calcium-binding protein S100B has been implicated in the pathology of bipolar affective disorder (BPAD) and schizophrenia (SZP). S100B protein levels are elevated in serum of patients with both disorders compared to controls. ...
