Browsing Psychiatry (Theses and Dissertations) by Title
Now showing items 10-29 of 74
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Caring for a child with an autistic spectrum disorder over the life span
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2003)Carers of children on the autistic spectrum have stressful lives (Randall & Parker, 1999). The aim of this study was to investigate the life of the carer, and in particular to examine how they have coped, their support ... -
Characterisation of MACROD2, a putative autism susceptibility gene : translating Genome-Wide Analysis to causation
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2013)Genome Wide Association studies (GWAS) have been used to identify genetic markers which have strong statistical association with a disease. Establishing a functional consequence of association is required to determine a ... -
Characterising schizophrenia candidate susceptibility genes using intermediate phenotypes
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2008)This thesis describes the use of intermediate phenotypes as a method for understanding, at a behavioural level, the functional significance of candidate susceptibility genes for schizophrenia. The historical context for ... -
Coercion and Involuntary Care: A Study of Involuntary and Voluntary Psychiatry Inpatients in Dublin
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2023)Involuntary care is a feature of mental health services around the world. In addition to involuntary admission and treatment, specific coercive or restrictive practices including seclusion and physical restraint occur in ... -
The Contribution of Additional Genetic Variation to CNV Carrier Cognitive and Neurodevelopmental Outcomes
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2023)Many copy number variants (CNV) are strongly associated with neurodevelopmental disorders (NDDs) such as autism, intellectual disability/developmental delay (ID/DD) and schizophrenia. CNVs are large genomic deletions or ... -
Deep Learning for Neuroimaging: Advancing Brain-Based Biomarkers of Autism Spectrum Disorder
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2023)In the last decade, deep learning (DL) has revolutionised fields like speech and vision through artificial neural networks. Can DL similarly transform biological psychiatry and neuroimaging? This thesis explores that ... -
Developing pedigree-based strategies to analyse whole genome sequencing data for complex disorders: learning from schizophrenia
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2023)Complex genetic disorders are impacted by a range of DNA variation. Next generation sequencing (NGS) allows for the direct examination of this variation, but large sample numbers are required to identify rare variants in ... -
Electroconvulsive therapy for depression : optimising treatment and exploring molecular mechanisms
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2016)The objective of this project was to explore clinical and molecular aspects of electroconvulsive therapy (ECT) in the treatment of depression, with a particular focus on the role of microRNAs (small, non-coding molecules ... -
Electroconvulsive therapy for depression and ketamine for relapse prevention: factors affecting response, cognition and research participation
This thesis comprises five clinical research studies. Study 1. Pilot randomised controlled trial: Ketamine vs midazolam for depression relapse prevention following successful electroconvulsive therapy (ECT), the ... -
Electrophysiological event-related-potentials & their association with genome-wide-associated risk variants in schizophrenia
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2012)This thesis describes the use of electrophysiological event- related-potentials as a method for understanding, at the cortical level, the functional significance of putative schizophrenia susceptibility genes identified ... -
Exploring Neurocognitive Factors Underlying Autism and Hyperphagia in Prader-Willi Syndrome
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2024)Background: Prader-Willi Syndrome (PWS) is a rare complex multisystem genetic disorder recognised as the most common genetic cause of life-threatening obesity in humans (Butler, 1996). The PWS genotype gives rise to a ... -
Exploring the Experience of Shame in Adult Survivors of Childhood Sexual Abuse Using a Mixed-Methods Approach
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2024)Childhood sexual abuse (CSA) is a worldwide problem that increases survivors' likelihood of experiencing a range of physical and mental health conditions. Survivors often feel, or are made to feel, shame surrounding their ... -
Exploring the molecular mechanisms of Rett syndrome
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2020)Rett Syndrome (RTT) is a severe neurological disorder that onsets between 6 to 18 months of age, after a period of apparently normal development. RTT affects approximately 1 in every 10000 to 15000 live births and is ... -
Family-based association and molecular genetic analysis of genes implicated in the aetiology of autism
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2009)Autism is an early onset neurodevelopmental disorder affecting three core areas of behaviour - communication, social behaviour and restricted/repetitive behaviour. Although family and twin studies indicate a genetic ... -
Frailty in an older population : the impact on community-dwelling elders, dementia patients and older caregivers
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2012)Frailty represents one of the greatest gerontological challenges faced by societies in coming years. Growing numbers of older citizens leads not only to increasing numbers of healthy elders, but also frail and disabled elders. -
Fuctional and structural brain changes in ageing related to emotional processing
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2012)Of all mental abilities emotional processing is well-preserved in healthy ageing. In spite of this, the neural substrates of emotional processing in ageing are still not fully understood. In this project several experiments ... -
Functional investigation of neurodevelopmental effects of DISC1 and related psychosis risk genes
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2015)Schizophrenia (SCZ) is a severe neurodevelopmental disorder, which affects about 1% of the population worldwide, and whose symptoms start during early adulthood. SCZ is determined by the interaction of genetic and environmental ... -
Functional neural differences in emotional regualtion between patients with MDD and healthy controls in the context of the vulnerability factors : family history of MDD, BDNF Val66Met polymorphism
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2012)Emotional regulation is a key mechanism which shows disturbances during major depressive disorder (MDD), and which may be modified by certain factors enhancing vulnerability to MDD. Two vulnerability factors were tested ... -
Genetic and molecular studies of rare variation in schizophrenia
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2014)Schizophrenia (SCZ) is a severe and debilitating disorder and it has a worldwide prevalence estimated at approximately 1%. The underlying pathogenesis of SCZ is poorly understood and there is a great need for diagnostic ... -
High dose right unilateral versus moderate dose bilateral ECT for major depression : time to re-orientation, physical functioning, quality of life and attitudes
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2012)The objective of this study was to compare the effects of 1.5 x seizure threshold (ST) bitemporal ECT with high dose (6 x ST) right unilateral (RUL) ECT with respect to immediate recovery from treatment, change in physical ...
