RSS 1.0Paediatrics (Theses and Dissertations)
Recent Submissions
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CRADLE - Circadian Rhythm Alteration anD neonataL Encephalopathy
(Trinity College Dublin. School of Medicine. Discipline of Paediatrics, 2023)Background: Neonatal Encephalopathy (NE) is a clinically defined syndrome of disturbed neurological function in the earliest days of life in term and near-term newborns. NE remains a major cause of mortality and morbidity ... -
SERENITY: SEveRE Neurological Impairment and children with medical complexiTY
(Trinity College Dublin. School of Medicine. Discipline of Paediatrics, 2022)Background and aims Children with Severe Neurological Impairment (SNI) have a significant disability as a result of a global impairment of the nervous system. They may be considered to be a subgroup of children with more ... -
Gender and Neonatal Inflammation in Preterm Outcome
(Trinity College Dublin. School of Medicine. Discipline of Paediatrics, 2021)Introduction: Preterm neonates are at high risk of sepsis and sepsis-related complications. Despite the prominence of sepsis in neonatal practice, there is no consensus definition and the role of organ dysfunction in ... -
PAEDIATRIC OUTCOMES AND SERUM BIOMARKER PANEL IN ACUTE TRAUMATIC BRAIN INJURY /CONCUSSION TO SEVERE TRAUMATIC BRAIN INJURY
(Trinity College Dublin. School of Medicine. Discipline of Paediatrics, 2020)Introduction Paediatric mild traumatic brain injury (mTBI) is increasingly recognised to have significant longer term neurocognitive effects. Childhood is a time of high risk for head injury. There were no national ... -
UNICORN; Underlying mechanisms in Neonatal Immune Metabolic Dysregulation and Brain Injury
(Trinity College Dublin. School of Medicine. Discipline of Paediatrics, 2020)Introduction: Neonatal encephalopathy (NE) is a clinically defined syndrome of disturbed neurologic function, in the earliest days of life. NE has a multifactorial aetiology and causes significant mortality and neurological ... -
Characterisation of innate immune responses in children with Down syndrome
(Trinity College Dublin. School of Medicine. Discipline of Paediatrics, 2020)Introduction: Down syndrome (DS) is associated with increased incidence of infections in childhood, higher mortality from sepsis, and other inflammatory conditions such as arthropathy, thyroid and coeliac disease. Several ... -
'Peas in a Pod?' - The body composition of the term and preterm infant
Introduction: Weight has been the primary outcome measure for many studies of both term and preterm infants. Body composition reflects the quality of infant growth. Using air displacement plethysmography, infant body ... -
CHAMPION STUDY: Childhood Assessment of Multi-organ dysfunction Post Neonatal encephalopathy
(Trinity College Dublin. School of Medicine. Discipline of Paediatrics, 2019)Neonatal brain injury is an important cause of neonatal death and disability such as cerebral palsy. Perinatal global hypoxic ischaemia associated with neonatal encephalopathy results in multi-organ dysfunction which may ... -
Developing a national reference range for paediatric bone density
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Paediatrics, 2014)This study aimed to acquire normative dual energy x-ray absorptiometry (DXA] bone density data for Irish Caucasian children. A total of 162 healthy Irish Caucasian children (84 male, 78 female) aged between six and 16 years ... -
National incidence study of insulin-dependent diabetes mellitus in childhood and adolescence in Ireland
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Paediatrics, 2001)Type 1 (insulin-dependent) diabetes mellitus is an important chronic medical condition that is associated with significant morbidity and premature mortality. The disease is considered so important that its incidence is ... -
Surveillance study on children and adolescents with Down Syndrome (3 months to 18.9 years) in the Eastern Regional Health Authority
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Paediatrics, 2006)Down syndrome is the most common cause of developmental disability in Ireland with a birth prevalence of 1 in 546 live births. Children with Down syndrome have a high incidence of associated treatable medical disorders. ... -
Children and adolescents with cystic fibrosis attending the three specialist Dublin respiratory units : clinical, metabolic, quality of life and genetic aspects
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Paediatrics, 2008)Patients with cystic fibrosis related diabetes (CFRD) have a six-fold increase in morbidity and mortality (Moran, 2002a). CFRD is usually asymptomatic and can remain undetected for up to four years prior to diagnosis. ... -
Children born small for gestational age (SGA) : growth and clinical assessment at age 4 to 6 years and treatment with recombinant growth hormone in children born SGA without catch up growth
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Paediatrics, 2009)Small for gestational age (SGA) is a descriptive term used to describe a baby who is bom smaller than expected for its gender and gestation. By international consensus the current definition is a birth weight ≥2 standard ... -
Continuous glucose monitoring in a cohort of prepubertal children with Type 1 diabetes mellitus : a comparison of glycaemic outcomes to clinical and biochemical markers of diabetes control
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Paediatrics, 2009)In type 1 diabetes, monitoring of glycaemic status is considered a cornerstone of diabetes care and vital in the prevention of diabetes complications. Intermittent daily self monitoring of blood glucose levels provides a ... -
Acidosis at birth in term infants and early neurophysiological and cardiovascular changes
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Paediatrics, 2005)This thesis was mounted to evaluate and quantify the role of umbilical cord pH measurements in relation to the baby’s clinical condition, electroencephalographic pattern, heart rate variability and analysis of sucking ...
