The human response to infection ranges from mild illness which is relatively well tolerated to a severe, potentially life-threatening syndrome termed severe sepsis. This thesis explored this response in patients hospitalised ...

The incidence of oesophageal cancer is rising in the developed world and has paralleled the rising prevalence of obesity. This is an aggressive malignancy with poor overall survival rates. Thus there is an impetus to ...

Barrett’s oesophagus is the leading risk factor for oesophageal adenocarcinoma. However, it is difficult to identify patients at risk of disease progression. Mitochondria are highly susceptible to mutations due to high ...