In the modem era there is a consistent reported trend of markedly improved operative and oncologic outcomes from high-volume oesophageal programmes within academic medical centres. The current benchmark survival rate in ...

The increasing incidence of oesophageal adenocarcinoma (OAC) parallels the rapidly rising incidence of obesity. OAC is an exemplar model of obesity-associated cancer, with an increasing focus on the role of visceral adipose ...

The current standard of care for oesophageal cancer in Ireland involves neoadjuvant chemoradiation therapy (CRT) followed by surgery. Despite advances in treatment, resistance to neoadjuvant CRT remains a significant ...

The incidence of overweight and obesity has reached pandemic proportions in modern society, affecting two thirds of the US and over half of the European population. Obesity is associated with increased morbidity and mortality ...

Contemporary clinical management of Barrett’s oesophagus has highlighted the lack of accurate predictors of neoplastic progression. Currently all Barrett’s patients undergo surveillance, however, only a subset of patients ...

Pancreatitis is an inflammatory disease of the pancreas and it may occur in either acute or chronic form, the former being life-threatening in its most severe form, and the latter being a progressive, irreversible disease ...

Barrett’s oesophagus (BO) develops in response to bile acid reflux and confers increased risk of progression to oesophageal adenocarcinoma (OAC). During this disease progression, the immune microenvironment of the oesophageal ...

Cancer rates are increasing with predictions of incidence rates doubling between 2000 and 2020. Although several factors are contributory, the rising incidence of overweight and obesity is currently thought to be fuelling ...

Incidences of obesity in the developed world represent a worrying epidemic. Obesity is associated with increased rates of diabetes, cardiovascular disease and cancer. Oesophageal adenocarcinoma rates have increased in the ...

This thesis explores the hypothesis that a cytokine mediated immune response modulates the human immune response to infection. Attenuation of this cytokine response may increase the risk of infection and sepsis in humans.