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Investigation of the molecular mechanisms underlying radioresistance in oesophageal cancer
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2011)
The current standard of care for oesophageal cancer in Ireland involves neoadjuvant chemoradiation therapy (CRT) followed by surgery. Despite advances in treatment, resistance to neoadjuvant CRT remains a significant ...
Obesity and cancer
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2011)
Cancer rates are increasing with predictions of incidence rates doubling between 2000 and 2020. Although several factors are contributory, the rising incidence of overweight and obesity is currently thought to be fuelling ...
Delineating the pro-carcinogenic pathways activated by obesity in Barrett's oesophagus
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2011)
Incidences of obesity in the developed world represent a worrying epidemic. Obesity is associated with increased rates of diabetes, cardiovascular disease and cancer. Oesophageal adenocarcinoma rates have increased in the ...