Browsing Surgery (Theses and Dissertations) by Title
Now showing items 27-46 of 46
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Local and systemic inflammation in oesophageal disease
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2010)Background: Reflux-induced injury and oxidative stress result in oesophageal inflammation and the potential for progression to intestinal metaplasia and adenocarcinoma. Proton-pump inhibitors represent the standard medical ... -
Malnutrition, deficiency, and nutritional practice in patients with acute and chronic pancreatitis
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2014)Pancreatitis is an inflammatory disease of the pancreas and it may occur in either acute or chronic form, the former being life-threatening in its most severe form, and the latter being a progressive, irreversible disease ... -
Mechanisms linking obesity, genomic instability and the radioresponse in oesophageal adenocarcinoma
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2014)The increasing incidence of oesophageal adenocarcinoma (OAC) parallels the rapidly rising incidence of obesity. OAC is an exemplar model of obesity-associated cancer, with an increasing focus on the role of visceral adipose ... -
Mitochondrial dysfunction during disease progression in Barrett's oesophagus
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2014)Barrett’s oesophagus is the leading risk factor for oesophageal adenocarcinoma. However, it is difficult to identify patients at risk of disease progression. Mitochondria are highly susceptible to mutations due to high ... -
Molecular analysis of cell proliferation and apoptosis in oesophageal adenocarcinoma
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2002)Cancer of the oesophagus is a particularly virulent gastrointestinal malignancy with poor prognosis. Replacement of the nomial squamous epithelium of the oesophagus with columnar epithelium (Barrett’s oesophagus) as a ... -
Molecular and radiological prediction of response to neo-adjuvant chemoradiation in patients with oesophageal cancer
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2009)The initial phase of the project’s laboratory component involved optimising techniques that would become necessary when analysing fresh oesophageal tissue. There are a number of commercially available techniques for tissue ... -
Molecular interactions in obesity and cancer
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2010)The incidence of overweight and obesity has reached pandemic proportions in modern society, affecting two thirds of the US and over half of the European population. Obesity is associated with increased morbidity and mortality ... -
Nutritional studies in upper gastrointestinal cancer
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2008)Carcinoma of the oesophagus, gastro-oesophageal junction and stomach represent aggressive diseases with a poor prognosis even in patients undergoing curative resection. Where squamous cell histology once predominated, the ... -
Obesity and cancer
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2011)Cancer rates are increasing with predictions of incidence rates doubling between 2000 and 2020. Although several factors are contributory, the rising incidence of overweight and obesity is currently thought to be fuelling ... -
Oesophageal cancer : association with visceral obesity, inflammation and optimisation of postoperative outcomes
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2013)The incidence of oesophageal cancer is rising in the developed world and has paralleled the rising prevalence of obesity. This is an aggressive malignancy with poor overall survival rates. Thus there is an impetus to ... -
Oesophageal inflammation and tumourigenesis - inherited variation in an Irish population
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2010)Cancer is a major medical challenge of this era and early diagnosis of cancer is critical to curative therapy. The search for biomarkers that may indicate the risk or presence of cancer is ongoing in thousands of laboratories ... -
Pelvic floor dysfunction : its assessment by MRI and strength duration test and its response to biofeedback
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2006)The component features of pelvic floor dysfunction (PFD) are interrelated but the development of a unified strategy to investigate and treat these problems has been slow; this has invariably affected the outcome of available ... -
Predictors of response of rectal cancer to neoadjuvant radiochemotherapy
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2007)Rectal cancers staged as cT3/T4 +/- node positive routinely receive neoadjuvant radiochemotherapy (RCT) followed by total mesorectal excision (TME). By this approach tumours can be both downstaged and downsized resulting ... -
Systemic inflammation after cardiac surgery
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2008)Genetically determined inter-individual variation in cytokine production, influences outcome in patients with systemic inflammation and severe sepsis. However outcome in patients with sepsis is also dependant on the presence ... -
The effect of major surgery on systemic and splanchnic immune function : examining the two-hit and gut hypotheses of the systemic inflammatory response syndrome
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2006)The systemic inflammatory response syndrome (SIRS), sepsis and multiple organ dysfunction syndrome (MODS) are recognized sequelae of complex major surgery and underlie significant morbidity and mortality. The systemic ... -
The immunomodulatory chemokine CCL28 in oesophageal disease progression
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2014)Barrett’s oesophagus (BO) develops in response to bile acid reflux and confers increased risk of progression to oesophageal adenocarcinoma (OAC). During this disease progression, the immune microenvironment of the oesophageal ... -
The role of the cyclooxygenase-2 - prostaglandin E2 cascade in pancreatic cancer associated angiogenesis
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2010)Medical therapy has failed to make any significant impact on survival in pancreatic cancer. Non Steroidal Anti-inflammatory Drugs (NSAIDs) have shown promise in several gastrointestinal (Gl) cancers. Evidence has suggested ... -
To survive or to thrive: An investigation into fatigue and associated factors on surgical performance
(Trinity College Dublin. School of Medicine. Discipline of Surgery, 2021)Background The issue of fatigue has been long-standing in the profession of surgery. Typically the term has been associated with performance decrement, and in particular, focus has been on mitigating fatigue to prevent ... -
Understanding the Role of MicroRNA-31 in Regulating Cellular Sensitivity to Chemoradiotherapy in Pancreatic Ductal Adenocarcinoma
(Trinity College Dublin. School of Medicine. Discipline of Surgery, 2023)Pancreatic adenocarcinoma (PDAC) is a lethal malignancy with a poor survival rate. One main challenge regarding PDAC is resistance to chemotherapy and radiotherapy. Therefore, there is an urgent requirement to characterise ... -
Visceral adiposity and oesophageal adenocarcinoma : exploring the role of the insulin like-growth factor axis
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2012)In the modem era there is a consistent reported trend of markedly improved operative and oncologic outcomes from high-volume oesophageal programmes within academic medical centres. The current benchmark survival rate in ...
