Prognostication, the prediction of future outcomes, is a key aspect of cancer care but remains imprecise. An elevated serum C-reactive protein (CRP) is associated with high symptom burden, poor quality of life and shorter ...

The larynx is the phonating mechanism, specifically designed for voice production.  Through movement of the cartilages, the larynx varies the opening between the vocal cords and thereby varies the pitch of sounds produced ...

Incidences of obesity in the developed world represent a worrying epidemic. Obesity is associated with increased rates of diabetes, cardiovascular disease and cancer. Oesophageal adenocarcinoma rates have increased in the ...

Oesophageal cancer is an aggressive malignancy associated with a poor 5-year survival of <20%, accounting for over 400,000 deaths each year. The current standard of care for oesophageal adenocarcinoma (OAC) ...

Radiation therapy is a mainstay of treatment for cancer. However, resistance to therapy remains a major clinical problem in rectal and oesophageal cancer, with at best only 27-30% of patients achieving a complete pathological ...

Background: Atherosclerotic cardiovascular diseases (CVD) including coronary heart disease, stroke and peripheral vascular disease are the commonest causes of death Worldwide. The underlying atherosclerosis starts early ...

The human response to infection ranges from mild illness which is relatively well tolerated to a severe, potentially life-threatening syndrome termed severe sepsis. This thesis explored this response in patients hospitalised ...

Title In vitro assessment of primary human chondrocyte viability following treatment with intra-articular contrast agents and local anaesthetic. Introduction Magnetic resonance (MR) and computed tomography (CT) direct ...

Oesophagogastric junctional adenocarcinoma (OGJ) is an aggressive malignancy with a high propensity to metastasise. Response rates to first-line chemo(radio)therapy regimens remain poor therefore, better treatment options ...