Show simple item record

dc.contributor.authorMc Carron, Maryen
dc.contributor.authorO'Connell, Juliette Anneen
dc.contributor.authorO'Dwyer, Maireen
dc.contributor.authorBurke, Eilishen
dc.contributor.authorO'Connell, Julietteen
dc.contributor.authorHenman, Martinen
dc.date.accessioned2020-03-13T14:57:23Z
dc.date.available2020-03-13T14:57:23Z
dc.date.issued2018en
dc.date.submitted2018en
dc.identifier.citationO'Connell, J., Burke, E., Mulryan, N., O'Dwyer, C., Donegan, C., McCallion, P., McCarron, M., Henman, M., O'Dwyer, M, Drug Burden Index to Define the Burden of Medicines in Older Adults with Intellectual Disabilities: An Observational Cross-Sectional Study, British Journal of Clinical Pharmacology, 84, 2018, 553 - 567en
dc.identifier.otherYen
dc.identifier.urihttps://bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bcp.13479
dc.identifier.urihttp://hdl.handle.net/2262/91794
dc.descriptionPUBLISHEDen
dc.description.abstractAims: The drug burden index (DBI) is a dose‐related measure of anticholinergic and sedative drug exposure. This cross‐sectional study described DBI in older adults with intellectual disabilities (ID) and the most frequently reported therapeutic classes contributing to DBI and examined associations between higher DBI scores and potential adverse effects as well as physical function. Methods: This study analysed data from Wave 2 (2013/2014) of the Intellectual Disability Supplement to the Irish Longitudinal Study on Ageing (IDS‐TILDA), a representative study on the ageing of people with ID in Ireland. Self‐ and objectively‐reported data were collected on medication use and physical health, including health conditions. The Barthel index was the physical function measure. Results: The study examined 677 individuals with ID, of whom 644 (95.1%) reported taking medication and 78.6% (n = 532) were exposed to medication with anticholinergic and/or sedative activity. 54.2% (n = 367) were exposed to high DBI score (≥1). Adjusted multivariate regression analysis revealed no significant association between DBI score and daytime dozing, constipation or falls. After adjusting for confounders (sex, age, level of ID, comorbidities, behaviours that challenge, history of falls), DBI was associated with significantly higher dependence in the Barthel index (P = 0.002). Conclusions: This is the first time DBI has been described in older adults with ID. Scores were much higher than those observed in the general population and higher scores were associated with higher dependence in Barthel index activities of daily living.en
dc.format.extent553en
dc.format.extent567en
dc.language.isoenen
dc.relation.ispartofseriesBritish Journal of Clinical Pharmacologyen
dc.relation.ispartofseries84en
dc.relation.urihttps://www-ncbi-nlm-nih-gov.elib.tcd.ie/pmc/articles/PMC5809360/en
dc.rightsYen
dc.subjectAgeingen
dc.subjectDrug utilizationen
dc.subjectPharmacoepidemiologyen
dc.titleDrug Burden Index to Define the Burden of Medicines in Older Adults with Intellectual Disabilities: An Observational Cross-Sectional Studyen
dc.typeJournal Articleen
dc.type.supercollectionscholarly_publicationsen
dc.type.supercollectionrefereed_publicationsen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/mccarrmen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/modwyer6en
dc.identifier.peoplefinderurlhttp://people.tcd.ie/eburke7en
dc.identifier.peoplefinderurlhttp://people.tcd.ie/oconnejuen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/mhenmanen
dc.identifier.peoplefinderurlhttp://people.tcd.ie/jaoconneen
dc.identifier.rssinternalid179646en
dc.identifier.doihttp://dx.doi.org/10.1111/bcp.13479en
dc.rights.ecaccessrightsopenAccess
dc.relation.doidoi: 10.1111/bcp.13479en
dc.relation.citesCitesen
dc.relation.citesCitesen
dc.subject.TCDThemeAgeingen
dc.subject.TCDThemeInclusive Societyen
dc.identifier.rssotherPMC5809360en
dc.subject.TCDTagANTICONVULSANT DRUGSen
dc.subject.TCDTagANTIDEPRESSANT DRUGSen
dc.subject.TCDTagANTIEPILEPTIC DRUGSen
dc.subject.TCDTagANTIPSYCHOTIC DRUGSen
dc.subject.TCDTagATYPICAL ANTIPSYCHOTIC-DRUGSen
dc.subject.TCDTagAgeing & Intellectual Disability Issuesen
dc.subject.TCDTagAgeing, Health and Intellectual Disabilityen
dc.subject.TCDTagAging and Intellectual Disabilityen
dc.subject.TCDTagClinical Pharmacyen
dc.subject.TCDTagDRUGS, EFFECTSen
dc.subject.TCDTagIntellectual Disabilityen
dc.subject.TCDTagMEDICATIONen
dc.subject.TCDTagMEDICATION MANAGEMENTen
dc.subject.TCDTagMEDICATION REVIEWen
dc.subject.TCDTagMEDICATION USEen
dc.subject.TCDTagMEDICATIONSen
dc.subject.TCDTagMedication Reconciliationen
dc.subject.TCDTagMedication burdenen
dc.subject.TCDTagMedication safetyen
dc.subject.TCDTagMedicinesen
dc.subject.TCDTagMental health and intellectual disabilityen
dc.subject.TCDTagNEUROLEPTIC MEDICATIONen
dc.subject.TCDTagPHARMACEUTICAL CAREen
dc.subject.TCDTagPHARMACY PRACTICEen
dc.subject.TCDTagPOLYPHARMACYen
dc.subject.TCDTagPSYCHOTROPICen
dc.subject.TCDTagPharmaceutical Policyen
dc.subject.TCDTagPharmaceutical care of the elderlyen
dc.subject.TCDTagPharmacyen
dc.subject.TCDTagPharmacy Researchen
dc.subject.TCDTagPractice of pharmacyen
dc.subject.TCDTagPrescription Medicinesen
dc.subject.TCDTagPsychotropic medicationen
dc.subject.TCDTagQUALITY USE OF MEDICINESen
dc.subject.TCDTaganticholinergic medicationen
dc.identifier.orcid_id0000-0002-2531-0422en
dc.subject.darat_impairmentAge-related disabilityen
dc.subject.darat_impairmentAutistic Spectrum disordersen
dc.subject.darat_impairmentChronic Health Conditionen
dc.subject.darat_impairmentEmotional-behavioural Problemsen
dc.subject.darat_impairmentEpilepsyen
dc.subject.darat_impairmentIntellectual Disabilityen
dc.subject.darat_impairmentMental Health/Psychosocial disabilityen
dc.subject.darat_impairmentPhysical disabilityen
dc.subject.darat_thematicHealthen
dc.status.accessibleNen


Files in this item

Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record