siRNA Library Screening Identifies a Druggable Immune-Signature Driving Esophageal Adenocarcinoma Cell Growth
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Journal ArticleDate:
2018Access:
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Duggan, S.P., Garry, C., Behan, F.M., Phipps, S., Kudo, H., Kirca, M., Zaheer, A., McGarrigle, S., Reynolds, J.V., Goldin, R., Kalloger, S.E., Schaeffer, D.F., Long, A., Strid, J. & Kelleher, D., siRNA Library Screening Identifies a Druggable Immune-Signature Driving Esophageal Adenocarcinoma Cell Growth, Cellular and Molecular Gastroenterology and Hepatology, 5, 4, 2018, 569-590Download Item:
1-s2.0-S2352345X18300195-main(1).pdf (PDF) 7.122MbAbstract:
This study de
fi
nes immune-associated factors supportive of
esophageal adenocarcinoma cell growth through small
interfering RNA screening and pathologic and functional
studies. Fostamatinib R788, targeting Janus kinase/signal
transducer-and-activator of transcription and TYRO protein
tyrosine kinase binding protein/spleen tyrosine kinase/AKT
serine-threonine kinase pathways, induced esophageal
adenocarcinoma cell death and reduced tumor burden in
xenografted mice.
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https://www.sciencedirect.com/science/article/pii/S2352345X18300195?via%3Dihubhttp://hdl.handle.net/2262/90819
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http://people.tcd.ie/longaihttp://people.tcd.ie/reynoljv
Author: Reynolds, John; Long, Aideen; Duggan, Shane P.; Garry, Catherine; Behan, Fiona; Phipps, Sinead; Kudo, Hiromi; Kirca, Murat; Zaheer, Abdul; McGarrigle, Sarah; Goldin, Robert; Kalloger, Steve E.; Schaeffer, David F.; Strid, Jessica; Kelleher, Dermot
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Journal ArticleURI:
https://www.sciencedirect.com/science/article/pii/S2352345X18300195?via%3Dihubhttp://hdl.handle.net/2262/90819
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Cellular and Molecular Gastroenterology and Hepatology;5;
4;
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Full text availableKeywords:
Immune-associated factors, Esophageal Adenocarcinoma, Barrett's esophagus, Inflammation, Therapeutic targetsDOI:
http://dx.doi.org/10.1016/j.jcmgh.2018.01.012Licences: