Structural basis for antagonism of innate immunity by poxvirus
Citation:
Shunichiro Oda, 'Structural basis for antagonism of innate immunity by poxvirus', [thesis], Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2011, pp 156Download Item:
Oda TCD THESIS 9577 Structural basis.pdf (PDF) 61.19Mb
Abstract:
Vaccinia virus encodes many proteins that antagonize our innate immune system. It has been shown that some of them adopt a Bcl-2 like fold in spite of a lack of sequence identities to the Bcl-2 superfamily. Unlike viral Bcl-2 homologs that antagonize apoptosis by binding to cellular Bcl-2 targets, these viral proteins serve other
functions. Despite the identification of numerous cellular targets for these proteins,
there is currently little structural information regarding the protein-protein complexes
formed during infection.
Author: Oda, Shunichiro
Advisor:
Khan, AmirQualification name:
Doctor of Philosophy (Ph.D.)Publisher:
Trinity College (Dublin, Ireland). School of Biochemistry and ImmunologyNote:
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Biochemistry, Ph.D., Ph.D. Trinity College Dublin.Licences: