Diquaternerised and Ru(11) based polypyridyl conjugates as biological probes and phototherapeutic agents
Citation:Robert B. P. Elmes, 'Diquaternerised and Ru(11) based polypyridyl conjugates as biological probes and phototherapeutic agents', [thesis], Trinity College (Dublin, Ireland). School of Chemistry, 2011, pp 366
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This Thesis entitled 'Diquaternerised and Ru(ll) Based Polypyridyl Conjugates as Biological Probes and Phototherapeutic Agents' is divided into 8 Chapters. Chapter 1, the introduction, gives a brief introduction to the cell cycle and its relevance to cancer treatment and is followed by a brief description of the structure of DNA and the different binding modes by which molecules may interact with it. A description of the photophysical properties of Ru(II) polypyridyl complexes and their DNA binding ability is also given and is supported by relevant examples from the literature. A brief introduction to photodynamic therapy (PDT) follows with particular emphasis on the applicability of certain Ru(II) conjugates. The introduction then deals with the excited state reactivity of the 1,8-naphthalimide chromophore and leads to a short review of gold nanoparticle (AuNP) conjugates and their applicability to biological use. This Chapter concludes with a description of ongoing research within the Gunnlaugsson research group and also describes the aims of the research conducted in each of the subsequent Chapters.
Author: Elmes, Robert B. P.
Qualification name:Doctor of Philosophy (Ph.D.)
Publisher:Trinity College (Dublin, Ireland). School of Chemistry
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Type of material:thesis
Availability:Full text available