MicroRNA: master controllers of intracellular signaling pathways.
File Type:
PDFItem Type:
Journal ArticleDate:
2015Author:
Access:
embargoedAccessEmbargo End Date:
2065-01-07Citation:
Lui PY, Jin DY, Stevenson NJ. MicroRNA: master controllers of intracellular signaling pathways, Cellular and Molecular Life Sciences, 72, 18, 2015, 3531 - 3542Download Item:
Abstract:
Signaling pathways are essential intracellular
networks that coordinate molecular outcomes to external
stimuli. Tight regulation of these pathways is essential to
ensure an appropriate response. MicroRNA (miRNA) is a
class of small, non-coding RNA that regulates gene
expression at a post-transcriptional level by binding to the
complementary sequence on target mRNA, thus limiting
protein translation. Intracellular pathways are controlled by
protein regulators, such as suppressor of cytokine signaling
and A20. Until recently, expression of these classical
protein regulators was thought to be controlled solely by
transcriptional induction and proteasomal degradation;
however, there is a growing body of evidence describing
their regulation by miRNA. This new information has
transformed our understanding of cell signaling by adding
a previously unknown layer of regulatory control. This
review outlines the miRNA regulation of these classical
protein regulators and describes their broad effects at both
cellular and disease levels. We review the regulation of
three important signaling pathways, including the JAK/
STAT, NF-jB, and TGF-b pathways, and summarize an
extensive catalog of their regulating miRNAs. This information
highlights the importance of the miRNA regulon
and reveals a previously unknown regulatory landscape
that must be included in the identification and development
of novel therapeutic targets for clinical disorders.
Sponsor
Grant Number
Science Foundation Ireland (SFI)
Author's Homepage:
http://people.tcd.ie/stevennjDescription:
PUBLISHED
Author: STEVENSON, NIGEL
Publisher:
SpringerType of material:
Journal ArticleCollections:
Series/Report no:
Cellular and Molecular Life Sciences;72;
18;
Availability:
Full text availableKeywords:
MicroRNA, Signal regulator, Regulon, JAK-STAT, NF-jB, TGF-b, Transcriptome-wideSubject (TCD):
Cancer , Immunology, Inflammation & InfectionLicences: