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dc.contributor.advisorConnor, Thomas
dc.contributor.authorHughes, Martina M.
dc.date.accessioned2017-01-19T12:24:59Z
dc.date.available2017-01-19T12:24:59Z
dc.date.issued2014
dc.identifier.citationMartina M. Hughes, 'Inflammation, the stress response system and the kynurenine pathway in the pathogenesis of depression and response to ECT', [thesis], Trinity College (Dublin, Ireland). Department of Physiology, 2014, pp 277
dc.identifier.otherTHESIS 10357
dc.identifier.urihttp://hdl.handle.net/2262/79051
dc.description.abstractMajor depression is a serious psychiatric disorder and a leading source of disability worldwide. However, the precise biological basis of depression remains elusive. Evidence suggests that activation of the inflammatory response system may have a pivotal role to play in the pathogenesis of certain subtypes of depression. Patients with severe treatment-resistant depression or with a history of childhood trauma are often characterised by a pro-inflammatory phenotype. In accordance with this, in this thesis, assessment of the circulating inflammatory profile in a cross-sectional cohort of severely depressed patients and additionally, in an independent cohort of severely depressed patients referred for ECT, revealed that both cohorts of depressed patients were characterised by increased circulating concentrations of the inflammatory cytokine IL-6 and the acute phase protein, C-reactive protein (CRP).
dc.format1 volume
dc.language.isoen
dc.publisherTrinity College (Dublin, Ireland). Department of Physiology
dc.relation.isversionofhttp://stella.catalogue.tcd.ie/iii/encore/record/C__Rb15662301
dc.subjectPhysiology, Ph.D.
dc.subjectPh.D. Trinity College Dublin
dc.titleInflammation, the stress response system and the kynurenine pathway in the pathogenesis of depression and response to ECT
dc.typethesis
dc.type.supercollectionthesis_dissertations
dc.type.supercollectionrefereed_publications
dc.type.qualificationlevelDoctoral
dc.type.qualificationnameDoctor of Philosophy (Ph.D.)
dc.rights.ecaccessrightsopenAccess
dc.format.extentpaginationpp 277
dc.description.noteTARA (Trinity’s Access to Research Archive) has a robust takedown policy. Please contact us if you have any concerns: rssadmin@tcd.ie


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