Browsing Mechanical, Manufacturing & Biomedical Eng by Sponsor "Irish Research Council (IRC)"
Now showing items 1-20 of 33
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Analysing the effects of 3D printing defects and surface roughness on the properties of acoustic materials
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2023)The principal aim of the research reported in this thesis was to investigate the influence of additive manufacturing on the acoustic performance of 3D printed periodic materials. First, a benchmark material design was ... -
A Biomechanical Assessment of Direct and Inertial Head Loading in Rugby Union
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2018)Rugby union is a territorial, dynamic and high-impact collision sport. Unfortunately, due to its physical and high impact nature, the incidence of concussion is high. There is mounting evidence that repeatedly sustaining ... -
Bovine pericardium of high fibre dispersion has high fatigue life and increased collagen content; potentially an untapped source of heart valve leaflet tissue
(2020)Bioprosthetic heart valves (BHVs) are implanted in aortic valve stenosis patients to replace the native, dysfunctional valve. Yet, the long-term performance of the glutaraldehyde-fixed bovine pericardium (GLBP) leaflets ... -
Collagen fibre characterisation in arterial tissue under load using SALS
(2017)The collagen fibre architecture of arterial tissue is known to play a key role in its resultant mechanical behaviour, while maladaptive remodelling of this architecture may be linked to disease. Many of the techniques ... -
Collagen fibre orientation and dispersion govern ultimate tensile strength, stiffness and the fatigue performance of bovine pericardium
(2019)The durability of bovine pericardium leaflets employed in bioprosthetic heart valves (BHVs) can significantly limit the longevity of heart valve prostheses. Collagen fibres are the dominant load bearing component of bovine ... -
Control of a Dynamic Wheeled-legged Robot Powered by Electric-Pneumatic Actuators
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2023)The implementation of wheels on the end distal of a mobile robot's leg is a design approach that is gaining increasing popularity as it enables improved energy efficiency, stability and adaptive locomotion strategies in ... -
Deciphering the Molecular Mechanisms of Stem Cell Mechanotransduction: A New Avenue for the Development of Therapeutics for Osteoporosis
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2019)Osteoporosis is characterised by reduced bone density and weakened bone architecture leading to high fracture risk. The changes in bone result from an imbalance in the bone remodelling cycle whereby the rate of resorption ... -
The development of biomimetic scaffolds for osteochondral tissue engineering
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2020)Articular cartilage (AC) is a soft tissue lining the ends of the bones in our joints. Even minor lesions in AC cause pain, impaired mobility and can develop to osteoarthritis (OA), a disease affecting millions of adults ... -
Development of mechanobiomimetic strategies to drive stem cell behaviour for bone regeneration
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2019)There are a host of cases where clinical intervention must be taken to treat diseased or damaged bone, including severe fractures, defects, tumours requiring tissue removal, and debilitating diseases such as osteoporosis. ... -
Fundamental Insights into Arterial Remodelling; Strain-Mediated Degradation of Arterial Collagen
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2019)Maladaptive remodelling of structurally significant collagen fibres in the arterial wall is believed to play a critical role in the development and progression of degenerative arterial disease. A greater understanding of ... -
Grasping Moving Objects: Adaptive Motion Through Tactile Sensing
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2022)The aim of this project is to explore how adaptive grasping motions, informed by real-time tactile feedback, can improve grasp robustness when grasping moving objects. It was hypothesised that an adaptive grasping motion, ... -
Human bone marrow stem/stromal cell osteogenesis is regulated via mechanically activated osteocyte-derived extracellular vesicles
(2020)Bone formation or regeneration requires the recruitment, proliferation, and osteogenic differentiation of stem/stromal progenitor cells. A potent stimulus driving this process is mechanical loading. Osteocytes are ... -
The Impact of Additive Manufacturing on the Acoustic Performance of Novel Porous Materials
(2022)Commonly used conventional acoustic porous materials suffer from a limited operational frequency range and great dependency of the sample thickness on their performance. For this reason, acoustic metamaterials have caught ... -
Investigation into the collagen fibre-mediated fatigue mechanics of bovine pericardium for use in bioprosthetic heart valves
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2021)Bioprosthetic heart valve replacements have long been associated with inadequate durability in vivo, owing primarily to mechanical damage and calcification of the glutaraldehyde-fixed bovine pericardial leaflets (GLBP). ...