Browsing Mechanical, Manufacturing & Biomedical Eng by Author "Kelly, Daniel"
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3D bioprinting of prevascularised implants for the repair of critically-sized bone defects
Kelly, Daniel (2021)For 3D bioprinted tissues to be scaled-up to clinically relevant sizes, effective prevascularisation strategies are required to provide the necessary nutrients for normal metabolism and to remove associated waste by-products. ... -
3D bioprinting spatiotemporally defined patterns of growth factors to tightly control tissue regeneration
Kelly, Daniel (2020)Therapeutic growth factor delivery typically requires supraphysiological dosages, which can cause undesirable off-target effects. The aim of this study was to 3D bioprint implants containing spatiotemporally defined patterns ... -
3D printed microchannel networks to direct vascularisation during endochondral bone repair
Kelly, Daniel; Cunniffe, Gr?inne (2018)Bone tissue engineering strategies that recapitulate the developmental process of endochondral ossification offer a promising route to bone repair. Clinical translation of such endochondral tissue engineering strategies ... -
3D printing of fibre-reinforced cartilaginous templates for the regeneration of osteochondral defects
Kelly, Daniel (2020)Successful osteochondral defect repair requires regenerating the subchondral bone whilst simultaneously promoting the development of an overlying layer of articular cartilage that is resistant to vascularization and ... -
Affinity-bound growth factor within sulfated interpenetrating network bioinks for bioprinting cartilaginous tissues
Kelly, Daniel (2021)3D bioprinting has emerged as a promising technology in the field of tissue engineering and regenerative medicine due to its ability to create anatomically complex tissue substitutes. However, it still remains challenging ... -
Anisotropic Shape-Memory Alginate Scaffolds Functionalized with Either Type I or Type II Collagen for Cartilage Tissue Engineering
Kelly, Daniel; Buckley, Conor (2017) -
Biofabrication and bioprinting using cellular aggregates, microtissues and organoids for the engineering of musculoskeletal tissues
Kelly, Daniel (2021)The modest clinical impact of musculoskeletal tissue engineering (TE) can be attributed, at least in part, to a failure to recapitulate the structure, composition and functional properties of the target tissue. This has ... -
Biofabrication of multiscale bone extracellular matrix scaffolds for bone tissue engineering
Kelly, Daniel; Freeman, F.E.; Browe, D.C.; Díaz-Payno, P.J.; Nulty, J.; Von Euw, S.; Grayson, W.L. (2019)Interconnected porosity is critical to the design of regenerative scaffolds, as it permits cell migration, vascularisation and diffusion of nutrients and regulatory molecules inside the scaffold. 3D printing is a promising ... -
Biofabrication of Prevascularised Hypertrophic Cartilage Microtissues for Bone Tissue Engineering
Kelly, Daniel (2021)Bone tissue engineering (TE) has the potential to transform the treatment of challenging musculoskeletal pathologies. To date, clinical translation of many traditional TE strategies has been impaired by poor vascularisation ... -
Biofabrication of spatially organised tissues by directing the growth of cellular spheroids within 3D printed polymeric microchambers
Kelly, Daniel; Daly, Andrew C. (2019)Successful tissue engineering requires the generation of human scale implants that mimic the structure, composition and mechanical properties of native tissues. Here, we report a novel biofabrication strategy that enables ... -
Biofabrication of vasculature in microphysiological models of bone.
Hoey, David; Kelly, Daniel (2021)Bone contains a dense network of blood vessels that are essential to its homoeostasis, endocrine function, mineral metabolism and regenerative functions. In addition, bone vasculature is implicated in a number of prominent ... -
Biomaterial-based endochondral bone regeneration: A shift from traditional tissue engineering paradigms to developmentally inspired strategies
Kelly, Daniel; Sheehy, Eamon J.; O'Brien, Fergal J. (2019)There is an urgent, clinical need for an alternative to the use of autologous grafts for the ever increasing number of bone grafting procedures performed annually. Herein, we describe a developmentally inspired approach ... -
Chondrocyte based Intraoperative Processing Strategies for the Biological Augmentation of a Polyurethane Meniscal Replacement
Buckley, Conor; Kelly, Daniel (2017) -
Combining BMP-6, TGF-β3 and hydrostatic pressure stimulation enhances the functional development of cartilage tissues engineered using human infrapatellar fat pad derived stem cells
Kelly, Daniel; Buckley, Conor (2013)The objective of this study was to identify a combination of growth factors that could be used with hydrostatic pressure (HP) stimulation to enhance the functional development of cartilaginous grafts engineered using human ... -
Combining freshly isolated chondroprogenitor cells from the infrapatellar fat pad with a growth factor delivery hydrogel as a putative single stage therapy for articular cartilage repair
Ahearne, Mark; Kelly, Daniel (2014)Growth factor delivery systems incorporating chondroprogenitor cells are an attractive potential treatment option for damaged cartilage. The rapid isolation, processing, and implantation of therapeutically relevant numbers ... -
Controlled Non‐Viral Gene Delivery in Cartilage and Bone Repair: Current Strategies and Future Directions
Kelly, Daniel (2018)Recent advances in the approval and commercialization of gene therapeutics have fostered the return of gene therapy to center stage. But despite new optimism, no Food and Drug Administration approved product exists for the ... -
Controlled release of transforming growth factor-?3 from cartilage-extra-cellular-matrix-derived scaffolds to promote chondrogenesis of human-joint-tissue-derived stem cells.
Kelly, Daniel; Cunniffe, Gr?inne; Buckley, Conor (2014)Abstract: The objective of this study was to develop a scaffold derived from cartilaginous extracellular matrix (ECM) that could be used as a growth factor delivery system to promote chondrogenesis of stem cells. ... -
Cyclic tensile strain can play a role in directing both intramembranous and endochondral ossification of mesenchymal stem cells.
Buckley, Conor; Kelly, Daniel (2017) -
Development of a New Bone¿Mimetic Surface Treatment Platform: Nanoneedle Hydroxyapatite (nnHA) Coating
Hoey, David; Kelly, Daniel (2020)The hierarchical structure of bone plays pivotal roles in driving cell behavior and tissue regeneration and must be considered when designing materials for orthopedic applications. Herein, it is aimed to recapitulate the ... -
A Developmental Engineering-Based Approach to Bone Repair: Endochondral Priming Enhances Vascularization and New Bone Formation in a Critical Size Defect
Kelly, Daniel (2020)There is a distinct clinical need for new therapies that provide an effective treatment for large bone defect repair. Herein we describe a developmental approach, whereby constructs are primed to mimic certain aspects of ...