The relationship between blood perfusion and thermal measurements at the skin surface
Citation:Christopher P. B. Nicholson, 'The relationship between blood perfusion and thermal measurements at the skin surface', [thesis], Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2006, pp 191
Nicholson TCD THESIS 8567 The relationship.pdf (PDF) 103.8Mb
Blood perfusion is defined as the volumetric flow rate of blood through a given volume of tissue. Blood perfusion measurements are an important clinical indicator for many medical conditions but to date there is no cost effective and accurate measurement solution available. Among a number of existing perfusion measurement techniques there is a range of thermal methods; these thermal methods offer the prospect of cheap and accurate perfusion measurement devices. The aim of this study is to investigate the relationship between non-invasive surface thermal measurements and the perfusion levels in the various tissues of the lower arm, leg and finger with a view to ultimately developing a practical, non-invasive and cost effective perfusion measurement device. The most promising thermal technique to date is known as the Forced Convection Approach in which a localised cooling load is applied to a small section of the skin surface using a perfusion probe. The thermal response at the surface is then related to the value of perfusion using a numerical model of the system based on an appropriate bio-heat model. Initial work repeating that of previous researchers identified a number of areas in which experimental and numerical improvements were required. A number of important developments were first made to the experimental procedure. A greater appreciation of the simplifying assumptions and applicability of the model was then developed. A crucial development was the concept of the Possible Perfusion Values curve; this refined approach was then implemented. A further simpler but novel technique, namely the Steady State Perfusion Measurement Technique was also developed based on the PPV methodology.
Author: Nicholson, Christopher P. B.
Qualification name:Doctor of Philosophy (Ph.D.)
Publisher:Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering
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Type of material:thesis
Availability:Full text available